HDM-induced chronic airway inflammatory cytokines decreased in TSLPR deficient mice. حسب Latifa Koussih (326043)

<b>Diroximel fumarate acts through Nrf2 to attenuate methylglyoxal-induced nociception in mice and decrease ISR activation in DRG neurons</b> حسب Muhammad Saad Yousuf (20745168)

Growth and <i>in vitro</i> differentiation of <i>B</i>. <i>cinerea</i> B05.10 (WT) and mutants generated in this study. حسب Thomas Leisen (9248883)

NatB inactivation decreased the level of MAPK and proposed model of EGFR/MAPK signaling regulation by NatB and the N-end rule pathways. حسب Zhentao Sheng (107495)

"…<p>(A-B) <i>psid-D1</i> (A) or <i>psid-D4</i> (B) clones in 3rd instar fat body, which were marked by GFP expression (pointed by arrowheads), showed decreased MAPK levels (anti-MAPK staining, red). (C) <i>psid-D4</i> clones in wing disc, marked by GFP expression (pointed by arrowheads), showed decreased MAPK level. …"

Overexpression of CCP5A and CCP5B induced flagellum length decrease and cell cycle defects. حسب Louise Basmaciyan (4576624)

Differences in abundance of non-lipid molecules in liver of <i>Fmo5</i>^<i>-/-</i> and WT mice. حسب Ian R. Phillips (5074121)

"…Red dots are non-lipids that are significantly increased or decreased in <i>Fmo5</i>^<i>-/-</i> mice with a -log₁₀ <i>q</i> above 1.301 (<i>q</i> <0.05) (grey line). …"

AMPK phosphorylation and AC5 and AC6 gene expression in hearts from WT and AMPKα2-/- mice following TAC. حسب Anne Garnier (130125)

الموضوعات:

Identification of Gut Microbiota Biomarker Genera Distinguishing Wild and Captive Animals (A) Top 50 discriminative genera selected by random forest classifier, ranked by mean decrease accuracy. حسب Lin Xu (94491)

Correlation between hub genes and 50 hallmark signaling pathways. حسب Jiyong Zhang (2498740)

Sensitivity analysis for IC₅₀ and <i>ε</i>_max as a function of measurement time. حسب Hope Murphy (8843516)

The IC50 value of Tan in normal esophageal HET-1A cells. حسب Dong Yang (141041)

Assessment of exoprotein concentration in a 50-mL culture of MH96. حسب Marion Schoof (11999106)

Stability parameters for SpGrx3 WT and mutants. حسب Trang Van Tran (16913946)

Kinetic parameters of SpGrx3 WT and mutants. حسب Trang Van Tran (16913946)

Modeled structures of C1-RhoGAP domain of WT PARG1, I845V and T622M mutants. حسب Zen Kouchi (14898435)

<i>Ang1</i>-KO mice develop more severe colitis compared to WT mice. حسب Alexander Hu (14755811)

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation حسب Kairui Yue (11874403)

"…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …"

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation حسب Kairui Yue (11874403)

"…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …"

Host population bottlenecks decrease microbiome diversity. حسب Michael Ørsted (5926028)

FTY720 decreased viability, proliferation, and motility and induced apoptosis in human hepatoblastoma cells. حسب Laura L. Stafman (6577184)

"…<p>(A) Following 24 hours of treatment with FTY720, the viability of HuH6 cells measured using the alamarBlue cell viability assay was significantly decreased (LD₅₀ = 8.4 μM, p ≤ 0.05). …"