Rac2 promotes differentiation of M2 macrophages <i>in vitro</i>. by Shweta Joshi (555748)

“…(D) & (E), Heatmap representation of metabolites across BMDMs from WT (n = 5) and Rac2-/- (n = 5) mice. Shades of yellow represent elevation of a metabolite and shades of blue represent decrease of a metabolite relative to the median metabolite levels (see color scale). …”

SLS-4 is required for the <i>in vitro</i> ubiquitination of poly-SUMO-2 chains and degradation of SUMO conjugates <i>in vivo</i>. by Chris Boutell (205885)

“…<p>(A) <i>In vitro</i> ubiquitination reactions were carried out in the presence of E1, UbcH5a and ubiquitin (Ubmix), poly-SUMO-2 chains and purified wt ICP0, ICP0ΔRING, or ICP0 C-terminal truncation mutants ICP01-323, ICP01-396 or ICP01-396mSLS-4 as indicated (-/+). …”

Table_1.pdf by Hena Ahmad (4995290)

“…Both, western blot and confocal microscopy confirmed an increase of ataxin-2 in BE(2)-M17 cells transduced with lentivirus expressing mt-ELF2 (CEE-mt-ELF2), which was not observed in cells transduced with lentivirus expressing wt-ELF2 (CEE-wt-ELF2). Moreover, we observed a significant decrease in the number and size of lipid droplets in the CEE-mt-ELF2-transduced BE (2)-M17 cells, but not in the CEE-wt-ELF2-transduced BE (2)-M17. …”

Image_1.pdf by Hena Ahmad (4995290)

“…Both, western blot and confocal microscopy confirmed an increase of ataxin-2 in BE(2)-M17 cells transduced with lentivirus expressing mt-ELF2 (CEE-mt-ELF2), which was not observed in cells transduced with lentivirus expressing wt-ELF2 (CEE-wt-ELF2). Moreover, we observed a significant decrease in the number and size of lipid droplets in the CEE-mt-ELF2-transduced BE (2)-M17 cells, but not in the CEE-wt-ELF2-transduced BE (2)-M17. …”

<i>Mmp13</i>^−/− mice display increased bone volume during non-stabilized fracture healing. by Danielle J. Behonick (81485)

“…Scale bar = 1 mm (B) Histomorphometric measurements of total bone volume (BV) and total bone volume as a proportion of total callus volume (BV/TV) in WT and <i>Mmp13</i>^−/− mice at days 7 (WT <i>n</i> = 6, <i>Mmp13</i>^−/−<i>n</i> = 6), 10 (WT <i>n</i> = 8, <i>Mmp13</i>^−/−<i>n</i> = 6), 14 (WT <i>n</i> = 8, <i>Mmp13</i>^−/−<i>n</i> = 6), 21 (WT <i>n</i> = 6, <i>Mmp13</i>^−/−<i>n</i> = 6), 28 (WT <i>n</i> = 6, <i>Mmp13</i>^−/−<i>n</i> = 6) and 56 (WT <i>n</i> = 5, <i>Mmp13</i>^−/−<i>n</i> = 4) confirm this observation There is a statistically significant decrease in BV in <i>Mmp13</i>^−/− calluses compared with WT at day 7 (*p<0.05), but a statistically significant increase in BV and BV/TV in <i>Mmp13</i>^−/− calluses compared with WT at days 28 (**p<0.01 and p<0.05 respectively) and 56 (*p<0.05). …”

Search results of kinetic parameter space and prediction of MdmX effect. by Sohyoung Kim (253617)

“…</p>c<p>The presence of MdmX (upto 100 fold k15) decreased maximum value (peak of oscillations) by >30%.…”

Rho-mediated control of <i>kinB</i> transcription is removed during sporulation. by Vladimir Bidnenko (4258573)

“…The highlighted points correspond to the WT profiles shown in panel (A): LBtran (orange), S1 (green), S5 (blue), S6 (pink); and RM (red) and WT (black) during exponential growth in LB. …”

Representation of the GE356 Fab crystal structure and paratope mapping analysis. by Marjon Navis (92808)

“…The color-coding reflects fold-decrease in binding or of neutralization activity as compared to WT, in red (>50× WT), dark orange (20–50× WT), light orange (10–20× WT) and yellow (5–10× WT). …”

<i>Tle4</i> null mice have cell-intrinsic defects in HSPC self-renewal and B-cell development. by Justin C. Wheat (621068)

“…(d) Analysis of B-cell differentiation in the BM of recipient mice 32 weeks after transplant by quantitation of ProB Fractions shows an increase in Fraction C, but decreased Fractions D and E indicating a relative block in differentiation between Fractions C and D (n = 5 per genotype, *: <i>P</i><.05 analysis of bone marrow weeks after transplant showed no significant differences between ko and wt recipients in the absolute number lks clp cmp or gmp compartments but did show a decrease meps recipient mice. competitive homing hours transplantation using whole bm from two week old littermates defect ability index is represented as: input src="http://www.plosone.org/article/fetchObject.action?…”

Blockade of GKAP degradation prevents Aβ-induced actin cytoskeleton remodeling. by Francesco Roselli (211670)

“…Upon Aβ treatment, GKAP-WT cluster size decreased to 64.4±11.5% (p<0.05) of vehicle-treated control. …”

Upstream bubble collapse and transition into elongation are delayed in the P266L mutant. by Guo-Qing Tang (540328)

“…The number of DNA molecules that were analyzed to draw the smFRET histograms are as follows: P266L: 3110 at 1 min; 4164 at 5 min; 4883 at 33 min. WT: 3444 at 1 min; 3432 at 5 min; 5855 at 34 min. …”

Image_2_Influence of Step Frequency on the Dynamic Characteristics of Ventilation and Gas Exchange During Sinusoidal Walking in humans.TIF by Mako Fujita (12403201)

“…<p>We tested the hypothesis that restricting either step frequency (SF) or stride length (SL) causes a decrease in ventilatory response with limited breath frequency during sinusoidal walking. …”

Image_3_Influence of Step Frequency on the Dynamic Characteristics of Ventilation and Gas Exchange During Sinusoidal Walking in humans.TIF by Mako Fujita (12403201)

“…<p>We tested the hypothesis that restricting either step frequency (SF) or stride length (SL) causes a decrease in ventilatory response with limited breath frequency during sinusoidal walking. …”

Do changes in size class composition influence American alligator spatial distributions? by Abby Lawson (750688)

“…The decrease in juvenile size classes we detected may reflect reduced reproductive activity mediated by removal of adults through harvest programs. …”

Image_1_Influence of Step Frequency on the Dynamic Characteristics of Ventilation and Gas Exchange During Sinusoidal Walking in humans.TIF by Mako Fujita (12403201)

“…<p>We tested the hypothesis that restricting either step frequency (SF) or stride length (SL) causes a decrease in ventilatory response with limited breath frequency during sinusoidal walking. …”

Image_4_Influence of Step Frequency on the Dynamic Characteristics of Ventilation and Gas Exchange During Sinusoidal Walking in humans.TIF by Mako Fujita (12403201)

“…<p>We tested the hypothesis that restricting either step frequency (SF) or stride length (SL) causes a decrease in ventilatory response with limited breath frequency during sinusoidal walking. …”

Supermarket policies on less-healthy food at checkouts: Natural experimental evaluation using interrupted time series analyses of purchases by Katrine T. Ejlerskov (6095291)

“…This decrease was sustained at 1 year with 185,100 (121,700–248,500) fewer packages purchased per 4 weeks per percentage market share—equivalent to a 15.5% reduction. …”

During iron depleted but not iron-replete conditions, HapX-deficiency impairs growth in liquid and solid media, colony formation from single conidia, conidiation, resistance to zin... by Markus Schrettl (240716)

“…High zinc-medium (hZn) contained 0.5mM ZnSO₄. The data in (A), (C), and (E) represent the means ± standard deviations from three independent experiments.…”

Growth states before drug exposure affect survival. by Akihisa Seita (10063260)

“…<p>(A) Decrease of division rate upon drug exposure. …”

Effects of mutations in highly conserved motif on OsCERK activity and function. by Fang-Cheng Bi (226018)

“…The values on the vertical axis, were normalized to wild-type (W.T.) rOsCERK activity at 100%. Note that the three variant proteins showed decreased activity, with the C461A variant showing the least activity. …”