Known transcripts differentially expressed in response to overexpression of , grouped according to functional classes by Haiqiong Montalta-He (54730)

“…Positive values indicate that the relative expression level of a gene is increased (upregulated) following overexpression and negative values indicate a decrease (downregulated). …”

Peptide binding affinities for human MHC II proteins. by Regina S. Salvat (682343)

“…The slope of the connecting lines are a relative measure of deimmunizing efficacy, where larger positive slopes indicate a greater fold decrease in affinity relative to wild type. …”

Fig 4 - by Rupamanjari Majumder (128411)

“…<p>A-E Effect of applying a light pulse (filled yellow rectangle) (0.092 mW/mm², 100 ms) to different phases of an action potential (AP). …”

Identification of AppY binding sequence <i>in vivo</i> and <i>in vitro</i>. by Naoual Derdouri (14808923)

“…Schematic representation of the pull-down assay. 1) Lysates containing AppY_WT-3Flag, AppY_K170E-3Flag or, as a control, a lysate made from cells containing the empty vector (pQE80L) were incubated with anti-Flag beads for purification. 2) Beads loaded with AppY_WT-3Flag or AppY_K170E-3Flag were incubated with DNA fragments labelled with Cy5 and corresponding to the promoter regions of <i>hyaA</i>, <i>gadE</i>, <i>gadY</i> or <i>malEK</i> as a control. …”

CD11b⁺ CD11c^high cell activation during <i>L</i>. <i>infantum</i> infection is enhanced in TLR4-deficient mice. by Laís Amorim Sacramento (8623041)

“…<p>(A-C) WT and <i>Tlr4</i>^-/- mice were i.v. infected with 10⁷ <i>L</i>. …”

Overexpression of CRMP1 suppressed filopodia and intense stress fibers formation. by Kay Ka-Wai Li (578608)

“…(M) The percentage of cells with filopodial protrusions was decreased in MB clones stably expressing CRMP1. A minimum of 100 individual cells of each clone were counted, and cells showing more than 20 filopodia were considered positive. …”

Extracellular Cu inhibits mSlo1 activation by Zhongming Ma (45963)

“…(C) Single channel I-V relation is unaffected by 100 μM Cu (top). Representative traces at +160 mV from a single channel patch show a marked decrease in P (bottom). …”

Role of Altered Enzyme Quantities on the Integration Properties of DARPP-32 by Maria Lindskog (65533)

“…A decrease in enzyme quantity produces a decrease in the change of PKAc during stimulation (dashed line) and an increase in the phosphoThr34 levels (dotted line). …”

The effect of dopamine on Δψ_m and [Ca²⁺]_c in midbrain neurons and astrocytes. by Sonia Gandhi (49260)

“…Figure bi demonstrates the increase in Rh123 fluorescence at 1 minute, 6 minutes and 12 minutes that reflects mitochondrial membrane depolarisation in PINK1 ko cells. c, d: Single cell traces of PINK1 ko neurons demonstrating that dopamine induced decrease in ΔΨ_m occurs independently of any change in [Ca²⁺]_c in some cells (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037564#pone-0037564-g001" target="_blank">Figure 1c</a>), whereas in other cells dopamine induced decrease in ΔΨ_m co-incides with a rise in [Ca²⁺]_c (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037564#pone-0037564-g001" target="_blank">Figure 1d</a>). e: Incubation with D1/D5 receptor antagonist SCH23390 (20 µM) did not alter the dopamine induced calcium signal or mitochondrial depolarisation in PINK1 ko neurons. f: Dopamine induced mitochondrial depolarisation was prevented by application of the PTP inhibitor 1 µM cyclosporine A.…”

Effect of OWB extract and CA on PGE2 release and COX-2 expression in LPS-induced murine peritoneal macrophages. by Durbadal Ojha (475076)

“…<p>(A) Overnight macrophage cultures were stimulated with LPS (1 µg/ml), and treated with OWB (50 or 100 µg/ml) or CA (10 µg/ml). …”

Data_Sheet_1_VIP Promotes Recruitment of Tregs to the Uterine–Placental Interface During the Peri-Implantation Period to Sustain a Tolerogenic Microenvironment.pdf by Lucila Gallino (8262564)

“…A similar molecular profile was observed at implantation sites of WT × WT mice treated with VIP antagonist at d3.5. …”

miR-9 suppressed the expression of cyclin D1 and Ets1 through post- transcriptional repression in gastric cancer cells. by Liduan Zheng (182440)

“…The symbols (* and #) indicate a significant decrease and a significant increase from mock or anti-NC, respectively.…”

Cell-cell fusions occur in <i>par-5</i> loss-of-function mutants. by Jessica H. Shinn-Thomas (847582)

“…<p>Time-lapse images of a <i>par-5(it55)</i> embryo show multiple cell-cell fusion events, as seen in 100% of observed embryos (n = 3). …”

Reduction in PD-1 Expression on Epitope-Specific CD8⁺ T Cells after Sequence Evolution in the Respective Epitopes by Hendrik Streeck (91376)

“…<p>Primary flow data (for the HLA-A3-restricted epitope A3-RK9 in p17 Gag [left]) and combined data for five individuals (right) for PD-1 expression on epitope-specific CD8⁺ T cells before (“WT–early”) and after (“variant–late”) the selection of amino acid substitutions within the targeted epitopes are shown. …”

Requirement of two polybasic clusters in the PIP_n-regulated P2X4 subtype. by Louis-Philippe Bernier (316296)

“…E) Wortmannin-induced PIP_n depletion leads to a stronger inhibition of P2X4 current amplitude in the K362Q-K363Q mutant than in WT (post/pre-treatment: WT: 61.3±7.5%, mutant: 29.5±4.6%, n = 30–50). *: p<0.05; ***: p<0.001.…”

Neutrophil recruitment, MMP9 secretion, and viral load are TLR-dependent. by Linda M. Bradley (173208)

“…The percentage of neutrophils after transfer of C57BL/6 (WT>WT) or <i>Myd88</i>^−/− (KO>WT) bone marrow into Ly5.1 congenic mice (<i>grey bars</i>) or after transfer of Ly5.1 bone marrow cells into Ly5.2+ C57BL/6 (WT>WT) or <i>Myd88</i>^−/− (WT>KO) recipients (<i>clear bars</i>) is shown. …”

Tamoxifen injection induced efficient recombination within <i>Cdc25A</i> and <i>Cdc25B</i> loci. by Gwanghee Lee (271155)

“…(B) Total RNA isolated from the small intestine (jejunum) of tamoxifen-treated WT and <i>vB^f/−</i> mice was reverse-transcribed into cDNA. qRT-PCR was used to determine relative amounts of <i>Cdc25B</i> mRNA. …”

Effects of IQ1 on mouse embryonic hearts. by Tomoyo Sasaki (87849)

“…(C) Mouse embryos were exposed to IQ1 from E12.5 to E14.5 <i>in utero</i>. β-galactosidase activity (blue) shows <i>Wt1</i>-derived cells in transverse heart sections. …”

Comparison of various inducer treatments on physiological and biochemical parameters in plants under drought conditions, relative to both drought-stressed and well-watered control... by Shelina Akter Sheuli (22446598)

“…Each parameter, such as chlorophyll, carotenoids, H₂O₂, proline, peroxidase (POD), glutathione S-transferase (GST) activity, and RWC, is normalized to the control, set at 100. Values exceeding 100 indicate an increase relative to the control, suggesting enhanced effects under treatment, while values below 100 signify a decrease, indicating reduced effectiveness compared to the control.…”

Comparison of various inducer treatments on physiological and biochemical parameters in plants under normal conditions, relative to well-watered control plants. by Shelina Akter Sheuli (22446598)

“…Each parameter—chlorophyll, carotenoids, H₂O₂, proline, peroxidase (POD), and glutathione S-transferase (GST) activity is normalized to the control, set at 100. Values exceeding 100 indicate an increase relative to the control, suggesting enhanced effects under treatment, while values below 100 signify a decrease, indicating reduced effectiveness compared to the control.…”