Effects of adenosine receptor-specific antagonists on responses to hypoxia at E9.5 and E12.5. by Daniela L. Buscariollo (140729)

“…<p>A and B: Specimens were treated with DPCPX, an A1AR-specific antagonist at 10 nM (A: E9.5, n = 15; B: E12.5, n = 23), SCH-58261, an A2aAR-specific antagonist at 100 nM (A: E9.5, n = 15; B: E12.5, n = 19), or vehicle (A: E9.5, n = 27; B: E12.5, n = 42) at 15 min (arrows), and exposed to hypoxia (gray boxes). …”

Transmembrane signaling in cell-derived plasma membrane vesicles. by Luigino Grasso (208932)

“…(D) The FRET signal increases with the concentration of agonist APEC added to the bulk solution (concentrations indicated above the bars in nM). (E) A dose-dependent increase of the FRET yields <i>EC₅₀</i> = 100±11 nM; shown are averages and standard deviations of the mean of nine titration experiments each performed on different, individual vesicles.…”

Deletion of <i>Wwox</i> results in defective mammary branching and lobuloalveolar development. by Brent W. Ferguson (167494)

“…<p>(A–B) Representative microphotographs obtained from whole mounts of 12 week virgin <i>BK5 Wwox WT</i> (A) and <i>KO</i> (B) mammary glands. …”

Loss of <i>faah-1</i> enhances <i>nape-1(OE)</i> phenotypes but suppresses <i>nape-2(OE)</i>. by Neale Harrison (665741)

“…(<b>D</b>) NAE levels in <i>nape-1(OE)</i> and <i>faah-1(tm5011); nape-1(OE)</i> grown at 25°C showed a significant linear trend towards increased levels (mean+sd, <i>faah-1(tm5011)</i> n = 9, <i>nape-1(OE)</i> n = 8 and <i>faah-1(tm5011); nape-1(OE)</i> n = 6 replicates, one sample test for deviation from 100% - *p<0.05). …”

<i>In vivo</i> H₂S treatment prevents O₂-induced arrested lung vascular growth. by Arul Vadivel (424484)

“…Arrows highlight vWF-positive vessels; scale bars represent 100 µm. B. Mean data quantifying the number of vWF positive vessels between groups. …”

Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain-4 by Kimberly R Tyeryar (59260)

“…The effects of neomycin alone on CDP-diacylglycerol were not significant, whereas it exerted a slight but significant increase at the 0.3 mM concentration (Dunett's, p < 0.01) and decrease at the 3 mM concentration (Dunnett, p < 0.01) in [H]phosphatidylinositide levels. …”

P1 and P2 particles avoid DOX toxicity towards cardiomyocytes. by Sibu P. Kuruvilla (4382191)

“…<b>(B)</b> Quantitation of the toxicity towards CMs as a measure of the decrease in confluence using the aforementioned mask, normalized to the positive control of Triton X-100. …”

Impact of 10 mM DCA on proliferation of mammary cell lines after 48 hours determined with fluorescence microscopy. by Tatjana P. Harting (4093507)

“…Statistical significant reduction of Ki67 was observed in ZMTH3, MTH52C and DT14/06T in comparison to non-treated control and non-neoplastic tissue derived cell line MTH53A. No significant decrease in proliferation could be determined in within neoplastic cell lines (I). …”

Gene expression in primary human skeletal muscle cells after treatment with acylcarnitines. by Rainer Lehmann (141280)

“…<p>mRNA expression of PGC-1α (A), CPT1b (B), CD36 (C), COX1 (D) and AngPL-4 (E) related to β-actin mRNA levels after incubation with 100 µM L-carnitine (L-C), an equimolar mixture of C8:0-, C10:0- and C12:0-acylcarnitine (total 100 µM; AC), 60 µM palmitate (p), or p and AC as indicated. …”

Effect of galactose treatment on oleic acid metabolism. by Eili Tranheim Kase (177084)

“…Suppressibility, defined as the ability of the cells to decrease oleic acid oxidation by acutely added glucose, was calculated as: [(1-(oxidation of oleic acid at 5 mM glucose/oxidation of oleic acid at no glucose added))×100%]. …”

PA5369 Is Involved in Adhesiveness and Ability of MDR25 and MPAO1 to Disrupt Epithelial Integrity by Olga Zaborina (40802)

“…<div><p>(A) Anti-PA5369 antibodies decrease the adhesiveness of strain MDR25 to Caco-2 monolayers<i>.…”

<i>In vivo</i> inhibition of ADAM15 activity reduces tumor growth. by Guadalupe Lorenzatti Hiles (2547727)

“…Subcutaneous inoculation of shA15UC6 cells (n = 10) in SCID mice led to decreased tumor weight compared to ctlA15UC6 control cells (n = 10) (<i>bottom</i>). …”

ZNF202 is involved in <i>AMACR</i> gene regulation in HCT 116 cells. by Xiang Zhang (19800)

“…<p>A: The ³²P labeled wild type (WT) probe corresponds to a sequence containing CG12-16 and its flanking regions (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000334#pgen-1000334-t005" target="_blank">Table 5</a>). …”

DataSheet_1_Safety, tolerability, pharmacokinetics and pharmacokinetic-pharmacodynamic modeling of cetagliptin in patients with type 2 diabetes mellitus.docx by Chen Zhou (466781)

“…Compared with placebo group, plasma active GLP-1 AUEC_0-24h increased by 2.20- and 3.36-fold in the 50 mg and 100 mg cetagliptin groups. A decrease of plasma glucose and increase of insulin and C-peptide were observed following OGTT in cetagliptin groups. …”

Data_Sheet_1_Coastal Flooding in the Balearic Islands During the Twenty-First Century Caused by Sea-Level Rise and Extreme Events.zip by Pau Luque (11248140)

“…We map projected flooded areas under two climate-change-driven mean sea-level rise scenarios (RCP4.5 and RCP8.5), together with the impact of an extreme event defined by the 100-year return level of joint storm surges and waves. …”

High oxygen concentration resulted in drastically reduced mRNA und protein expression of factors for neurodevelopment and plasticity, and DEX administration reversed these effects. by Stefanie Endesfelder (121559)

“…We detected in all plasticity factors a significant decrease under hyperoxic conditions for <b>A-E)</b> mRNA expression and <b>F-J)</b> protein expression. …”

Effect of high-voltage electrical stimulation and topical insulin on experimental cutaneous lesions by Rafaela Ferreira (3441404)

“…HVES was administered 24 hours after surgery, 30 minutes per day, with a frequency of 100 Hz and a mean voltage of 60 V, maintained at the motor threshold. …”

Defective TGF-β proliferative control in <i>Rb1^ΔL/ΔL</i> and <i>Rb1^ΔL/</i>⁺ mice. by Sarah M. Francis (355629)

“…Proportions were compared between genotypes using a chi-square test. Scale: 100 µm. † denotes previously published data that has been provided for comparison purposes.…”

Phenotypic changes following long term hypoxia selection. by Dan Zhou (29408)

“…A significant decrease at body weight was found in AF flies (lower panel, <i>p</i><0.01). …”

SopB inositol phosphatase activity is required for inhibition of <i>Salmonella</i> entry. by Robert J. Cain (272233)

“…Invasion rates after 60 min were compared to wild-type (assigned as 100%). Results are mean±SEM of 4 independent experiments each performed in triplicate. …”