Effect of pazopanib on primary tumor growth of breast cancer and melanoma cell lines. by Brunilde Gril (202357)

“…P values are shown for the tumors in which the decrease in tumor size achieved significance (p<0.01) at a given dose of pazopanib. …”

Infectivity of <i>LdASS</i> mutants in the murine model. by Abul Hasan Sardar (573177)

“…In the <i>LdASS</i>^-/-/+ parasites, the IL-12 and IFN-γ were increased whereas IL-10 and TGF-β were decreased compared to WT parasites. Each measurement was performed in triplicate and data are expressed as the mean. …”

Effect of conversion from calcineurin inhibitors to everolimus on hepatitis C viremia in adult kidney transplant recipients by Larissa Sgaria Pacheco (5221397)

“…The mean eGFR was similar in both groups. Conclusion: Our study did not show viral load decrease after conversion to EVR with maintenance of antiproliferative therapy.…”

Effect of conversion from calcineurin inhibitors to everolimus on hepatitis C viremia in adult kidney transplant recipients by Larissa Sgaria Pacheco (5221397)

“…The mean eGFR was similar in both groups. Conclusion: Our study did not show viral load decrease after conversion to EVR with maintenance of antiproliferative therapy.…”

Preventing age-related degeneration of proteoglycans in articular cartilage by CCN2 overexpression. by Shinsuke Itoh (125939)

“…<p>(A) Toluidine blue staining of frontal sections of medial portion of TG (a, c, e) and WT (b, d, f) littermate knee joints from 5- (a and b), 12- (c and d), and 24- (e and f) month-old male mice. …”

Additional file 7: of Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy by Nora Huang (3661855)

“…Twelve- to 16-week-old male Nlrp3 KO and WT mice were subjected to CLP or sham surgery. qRT-PCR analysis of myosin heavy chain (Myh) 2, Myh4, and Myh7 expression in tibialis anterior (TA) muscles of sham (n = 5) and CLP (n = 5) mice at 96 h after surgery as indicated (WT sham: n = 5; WT CLP: n = 9; Nlrp3 KO sham n = 5; Nlrp3 KO: CLP n = 6). mRNA expression was normalized to Gapdh. …”

Impact of community mask adherence and attitudes. by Dhaval Adjodah (11014160)

“…<p>Using a novel survey-based dataset of 847 thousand online Facebook survey respondents in 51 languages from 69 countries, we estimate that a 1% increase in community mask adherence is associated with a decrease of -0.61 [-0.82,-0.39] cases per 100K and a decrease of -0.035 [-0.040,-0.029] deaths per 100K. …”

Synthesis of flexible polyurethane foams by the partial substitution of polyol by steatite by Plínio César de Carvalho Pinto (5834999)

“…There is not a significant change in the chemical composition of the foams, due to substitution of 4.5 wt. % polyol by steatite. However, there was a decrease in cell size and greater interaction between the hard segments of the composite.…”

HDAC inhibition blocks Glyc-Alb induced activation of HDACs. by Danielle Desjardins (735474)

“…<p>(A) ARPE19 cells showed a significant decrease in Ac-α-tubulin at 6 h post treatment of Glyc-alb (100 μg/mL) compared to administration of the same concentration of Alb. …”

Arterial contractility 18 hours after CASP. by Stefan Felix Ehrentraut (136865)

“…<p><b>A</b> A significant hypocontractility of aortic rings in CASP- WT animals, but not in sham-operated WT animals was observed at phenylephrine concentrations of 10^−7,5 to 10⁻⁵M. …”

Assessment of cell viability using quantification of lactate dehydrogenase (LDH) released by lesioned retinas treated with GJ blockers and openers. by Vera Paschon (306542)

“…On the other hand, we observed changes in LDH release when retinas were treated with the same drugs with a higher concentration (100 µM). (E) After incubating with CBX 100 µM for 4 h, we detected a significant decrease in the LDH release (−22%, <i>P</i><0.01). …”

Reduced number of podcytes in CD73^−/−mice. by Cornelia Blume (321209)

“…(B) Statistical analysis showed a decreased number of WT1-stained podocytes per glomerulus (counted in 30 glomeruli per section and 7 mice per group), means ± SEM, p<0.0001 according to Student t-test (left panel). …”

Bcl-xL regulation of NF-κB RNAs: by Chi Zhang (9857)

“…<p>A: RNA was extracted from eggs and embryos at various stages and analyzed by RT-PCR (28 cycles); levels of RelA, Rel2, Rel3, RelB and Xp100 RNAs drop between stage 7 and 9 and, except for RelB, increase following gastrulation (stage 12/13). …”

Tg9949 mice are prone to neurological dysfunction but do not spontaneously generate prions. by David W. Colby (254454)

“…(<b>E</b>) Brain samples from six aged Tg9949 mice do not seed the formation of recPrP amyloid, as judged by an increase in Thioflavin T fluorescence (top) and by a decrease in the lag phase for amyloid formation (bottom). …”

FCF affects HIF-1α expression on the posttranslational level. by Dikla Vardi-Oknin (447319)

“…Quantitative real-time PCR analysis was done using primers for HIF-1α and cyclophilin B as control<i>. Columns</i>, means (n = 2); <i>bars</i>, SD. (<b>B</b>) PC-3 cells were treated with vehicle (control) and 100 μM FCF for 4 h under normoxia, and then CHX was added at a final concentration of 10 μg/ml for the indicated times. …”

The inhibition of mitochondrial respiratory chain complex activity by longer chain TPP⁺ compounds is dose dependent. by Jan Trnka (441288)

“…<p>Samples of rat skeletal muscle homogenate were incubated with various concentrations of decylTPP⁺ and dodecylTPP⁺ prior to the assay. <b>A, B, and C.</b> Complexes I, II, and III show a gradual decrease in activity proportionate with the dose of the TPP⁺ compounds. …”

cKO embryos display a variety of defects in the yolk sac mesoderm. by Siyeon Rhee (390224)

“…C, F) Section immunofluorescence of WT (C) and cKO (F) 9.5 <i>dpc</i> yolk sacs demonstrates loss of αSMA in the cKO. …”

The NADPH oxidase inhibitor VAS2870 protects the brain from damage during acute ischemic stroke. by Christoph Kleinschnitz (93826)

“…<p>(A) Left panel shows representative images of vital brain slices from sham-operated wild-type (WT) mice and wild-type mice and <i>Nox4</i>^−/− mice 12 h after tMCAO. …”

<i>Mll2^Gdf9</i> cKO oocytes show loss of bulk H3K4me2 and H3K4me3 as well as H4 hyperacetylation. by Claudia V. Andreu-Vieyra (243666)

“…In contrast, a decrease in H3K4me2 (B) and H3K4me3 (C) levels was observed in <i>Mll2^Gdf9</i> cKO oocytes (B and C, lower panels) compared to controls (B and C, upper panels). …”

Supplementary Material for: Carpal Tunnel Surgery as Proxy for Dialysis-Related Amyloidosis: Results from the Japanese Society for Dialysis Therapy by Hoshino J. (4145806)

“…<b><i>Methods:</i></b> The cohort consisted of 166,237 patients on dialysis (mean age 66.1 ± 12.4 years; mean dialysis vintage 7.2 ± 6.4 years) who could be followed for a year between 2010 and 2011. …”