Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications by Karel J. Hartlieb (1367880)

“…Although many promising chemotherapeutics have been developed upon the basis of polyaromatic DNA intercalating systems, these candidates did not proceed past clinical trials on account of their dose-limiting toxicity. Herein, we discuss an alternative, water-soluble class of polyaromatic compounds, the 2,9-diazaperopyrenium dications, and report <i>in vitro</i> cell studies for a library of these dications. …”

Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications by Karel J. Hartlieb (1367880)

“…Although many promising chemotherapeutics have been developed upon the basis of polyaromatic DNA intercalating systems, these candidates did not proceed past clinical trials on account of their dose-limiting toxicity. Herein, we discuss an alternative, water-soluble class of polyaromatic compounds, the 2,9-diazaperopyrenium dications, and report <i>in vitro</i> cell studies for a library of these dications. …”

Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications by Karel J. Hartlieb (1367880)

“…Although many promising chemotherapeutics have been developed upon the basis of polyaromatic DNA intercalating systems, these candidates did not proceed past clinical trials on account of their dose-limiting toxicity. Herein, we discuss an alternative, water-soluble class of polyaromatic compounds, the 2,9-diazaperopyrenium dications, and report <i>in vitro</i> cell studies for a library of these dications. …”

Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications by Karel J. Hartlieb (1367880)

“…Although many promising chemotherapeutics have been developed upon the basis of polyaromatic DNA intercalating systems, these candidates did not proceed past clinical trials on account of their dose-limiting toxicity. Herein, we discuss an alternative, water-soluble class of polyaromatic compounds, the 2,9-diazaperopyrenium dications, and report <i>in vitro</i> cell studies for a library of these dications. …”

Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications by Karel J. Hartlieb (1367880)

“…Although many promising chemotherapeutics have been developed upon the basis of polyaromatic DNA intercalating systems, these candidates did not proceed past clinical trials on account of their dose-limiting toxicity. Herein, we discuss an alternative, water-soluble class of polyaromatic compounds, the 2,9-diazaperopyrenium dications, and report <i>in vitro</i> cell studies for a library of these dications. …”

The induction of inflammatory genes was decreased in liver of CD44KO(HFD) compared to WT(HFD) mice. by Hong Soon Kang (386679)

Administration of anti-DJ-1 antibody decreased the inflammatory cytokine expression and attenuated ischemic neuronal injury. by Koutarou Nakamura (10833014)

Cardiac function assessed by echocardiography in Ang II–infused young (3 months) or old (18 months) WT and smcKlf5^−/− mice. by Dong Ma (584680)

Decreased E/I synapse ratio and loss of cortico-LA synaptic plasticity in the absence of coronin 1. by Rajesh Jayachandran (542641)

“…Scale bars, 100 pA and 20 ms. See <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001820#pbio.1001820.s018" target="_blank">Table S1</a> for additional statistics.…”

Loss of Runx1 in <i>mdx</i> mice decreases muscle mass, muscle strength and lifespan. by Kfir Baruch Umansky (783699)

Neuronal cell cultures derived from embryos injected with APPb-MO had decreased neurite length. by Ping Song (169215)

“…The neurons from the embryos injected with 8 ng of APPb-MO showed a decrease in neurite length compared to neurons from the control embryos (un-injected). …”

S100A1 can interfere with the interaction between p53 and MDM2/MDMX. by Deepu Dowarha (5673440)

Subjects:

Animation displaying S100A1−MDM2 complex generated via the HADDOCK program. by Deepu Dowarha (5673440)

Subjects:

Image_1_Acclimation of Photosynthesis to Changes in the Environment Results in Decreases of Oxidative Stress in Arabidopsis thaliana.JPEG by Mohd Fauzihan Karim (11470027)

Image_2_Acclimation of Photosynthesis to Changes in the Environment Results in Decreases of Oxidative Stress in Arabidopsis thaliana.JPEG by Mohd Fauzihan Karim (11470027)

Table_1_Acclimation of Photosynthesis to Changes in the Environment Results in Decreases of Oxidative Stress in Arabidopsis thaliana.DOCX by Mohd Fauzihan Karim (11470027)

Taurine Chloramine decreases cell viability and cytokine production in blood and spleen lymphocytes from septic rats by DHÉBORA M. DALL’IGNA (10365522)

“…Lymphocytes were cultured at a concentration of 1×106 cells/mL and activated by concanavalin A. …”

Filamentation induced by DTPA is associated with a decrease in Nrg1 protein level, and requires the cAMP-PKA pathway and the kinase Sok1. by Elizabeth J. Polvi (3163500)

Restoring Specific Lactobacilli Levels Decreases Inflammation and Muscle Atrophy Markers in an Acute Leukemia Mouse Model by Laure B. Bindels (155478)

“…The restoration of <em>Lactobacillus</em> species by oral supplementation with <em>L. reuteri</em> 100-23 and <em>L. gasseri</em> 311476 reduced the expression of atrophy markers (Atrogin-1, MuRF1, LC3, Cathepsin L) in the gastrocnemius and in the tibialis, a phenomenon correlated with a decrease of inflammatory cytokines (interleukin-6, monocyte chemoattractant protein-1, interleukin-4, granulocyte colony-stimulating factor, quantified by multiplex immuno-assay). …”

Mangiferin Decreases Plasma Free Fatty Acids through Promoting Its Catabolism in Liver by Activation of AMPK by Yucun Niu (186774)

“…Mangiferin (50, 100, 150 mg/kg BW) decreased dose-dependently FFA and triglycerides (TG) levels in plasma, and their accumulations in liver, but increased the β-hydroxybutyrate levels in both plasma and liver of hyperlipidemic rats. …”