GIRK2^AgRP-KO mice show increased body weight and adiposity independently of food intake. by Youjin Oh (3308670)

Differentially expressed genes in <i>pgl</i> vs WT. by Jisun Kim (837555)

“…These differences were also evident through unbiased metabolomics studies and ¹³C labeling experiments that showed mutation of <i>pgl</i> led to reductions in pyrimidine metabolism including decreases in ribose-5P, UMP and GMP. These nucleotide reductions impacted the amount of extracellular DNA in biofilms and reduced biofilm formation. …”

R117H-7T and R117H-5T function (+/-) ivacaftor: estimates from <i>in vitro</i> measurements of channel function and transcript analysis. by Jessica E. Char (476386)

“…Ivacaftor increases <i>P</i>_<i>O</i> 2–4 fold to give 15% (dashed line) to 30% WT function. (B) R117H-5T. The 5T mutation causes a large decrease in full-length transcripts and when combined with R117H reduces function to ~1.5% (column 3) and to 0.75% when the other allele is non-functional (column 4). …”

P-Rex-deficient Purkinje neurons have normal passive membrane properties and basal synaptic transmission. by Claire Jackson (362873)

(A and B) Immunofluorescence analysis of tumors grown in WT or Sema4D KO animals by Jose Rafael Sierra (50652)

Validation of AgRP neuron-specific <i>Girk1</i> and <i>Girk2</i> deletion. by Youjin Oh (3308670)

Decreased production of antiviral factors in patients infected with SARS-CoV-2 due to reduced TLR7 expression by Julia Cataldo Lima (22811497)

“…<p>The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic presents a major global health challenge. …”

ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity-5 by Rodrigo A Fuentealba (77901)

“…<p><b>Copyright information:</b></p><p>Taken from "ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity"</p><p>http://www.molecularneurodegeneration.com/content/2/1/14</p><p>Molecular Neurodegeneration 2007;2():14-14.…”

Intracellular killing of <i>K</i>. <i>pneumoniae</i> mutants. by Estelle Ifrid (10076719)

K2 treatment increases access of a hydrophobic probe to the bacterial membrane of <i>K</i>. <i>pneumoniae</i>. by Estelle Ifrid (10076719)

Decreased copper content and activity/expression of SOD1 in circulating erythrocytes from <i>ms/−</i> mice. by Małgorzata Lenartowicz (150659)

“…<p>(<b>A</b>) Decreased copper content in erythrocytes of <i>ms/−</i> mice. …”

Substitutions of amino acids 605 and 606 in PB2 affect RNP activity in an NP-dependent manner. by Ho-Pan Hsia (4768638)

Cells lacking the capacity to catabolize proline exhibit reduced vitality. by Fitz Gerald S. Silao (9384713)

VANGL2 specifically inhibits the activation of NLRP3 inflammasome. by Huaji Jiang (16907514)

Contribution of GIRK2-containing channels to RMP and GABA_B-induced inhibition of NPY neurons. by Youjin Oh (3308670)

“…(B, C) Bar graphs and dots summarize RMP (−47.9 ± 0.9 mV, <i>n</i> = 64, for NPY^G2WT and −44.5 ± 0.7 mV, <i>n</i> = 41, for NPY^G2KO, df = 103, t = 2.556, <i>p</i> = 0.012) (B) and input resistance (2.35 ± 0.11 GΩ, <i>n</i> = 64, for NPY^G2WT and 2.78 ± 0.11 GΩ, <i>n</i> = 41, for NPY^G2KO, df = 103, t = 2.590, <i>p</i> = 0.011) (C) of NPY^G2WT (<i>n</i> = 64, black) and NPY^G2KO (<i>n</i> = 41, red) neurons. …”

Gefitinib + Capmatinib decrease proliferation of <i>v-ras</i>^<i>Ha</i>-transduced wild type and <i>Tpl2</i>^-/- keratinocytes. by Mary B. Kelley (12290071)

Movie 2 Rik^null vs. WT. by Erdyni N. Tsitsikov (20384719)

IL-8 secretion decreased from TLR5 silenced (siRNA) Caco-2BBe cells exposed to flagellin. by Tonyia Eaves-Pyles (344135)

“…<p><b>A. </b><i>S. dublin</i> flagellin was added to the AP or BL surface of polarized Caco-2BBe cells where TLR5 was knocked down using siRNA. …”

VANGL2 recruits NLRP3 to OPTN for selective autophagic degradation. by Huaji Jiang (16907514)

LC–MS/MS analysis of 5-, 8-, 11-, 12- and 15-HETE levels in WT and Tie2-sEH Tr mouse heart perfusates at baseline and post-ischemia. by Ahmad Hanif (3094800)

“…<p>In Tie2-sEH Tr mice, the levels of 5-HETE (A), 8-HETE (B), 11-HETE (C), 12-HETE (D), 15-HETE (E), were decreased compared to WT mice at baseline and post-ischemia (<i>P</i> < 0.05). …”