R117H-7T and R117H-5T function (+/-) ivacaftor: estimates from <i>in vitro</i> measurements of channel function and transcript analysis. by Jessica E. Char (476386)

“…Ivacaftor increases <i>P</i>_<i>O</i> 2–4 fold to give 15% (dashed line) to 30% WT function. (B) R117H-5T. The 5T mutation causes a large decrease in full-length transcripts and when combined with R117H reduces function to ~1.5% (column 3) and to 0.75% when the other allele is non-functional (column 4). …”

Substitutions of amino acids 605 and 606 in PB2 affect RNP activity in an NP-dependent manner. by Ho-Pan Hsia (4768638)

Model of WT1 variant actions on the LHβ promoter. by Debalina Bagchi (686046)

“…Decreased expression of WT1 (+KTS) would stimulate basal LHβ expression as the suppressor is reduced. …”

Interactions between E1A and PKA are required for full HAdV-5 progeny production. by Cason R. King (2633092)

“…<p>A549 cells were treated with control siRNA or siRNA specific for PKA subunits and infected with either WT HAdV-5 or a virus encoding E1A unable to bind PKA (Δ4–25). …”

Differentially expressed genes in <i>pgl</i> vs WT. by Jisun Kim (837555)

“…These differences were also evident through unbiased metabolomics studies and ¹³C labeling experiments that showed mutation of <i>pgl</i> led to reductions in pyrimidine metabolism including decreases in ribose-5P, UMP and GMP. These nucleotide reductions impacted the amount of extracellular DNA in biofilms and reduced biofilm formation. …”

Gefitinib + Capmatinib decrease proliferation of <i>v-ras</i>^<i>Ha</i>-transduced wild type and <i>Tpl2</i>^-/- keratinocytes. by Mary B. Kelley (12290071)

Movie 2 Rik^null vs. WT. by Erdyni N. Tsitsikov (20384719)

(A and B) Immunofluorescence analysis of tumors grown in WT or Sema4D KO animals by Jose Rafael Sierra (50652)

LC–MS/MS analysis of 5-, 8-, 11-, 12- and 15-HETE levels in WT and Tie2-sEH Tr mouse heart perfusates at baseline and post-ischemia. by Ahmad Hanif (3094800)

“…<p>In Tie2-sEH Tr mice, the levels of 5-HETE (A), 8-HETE (B), 11-HETE (C), 12-HETE (D), 15-HETE (E), were decreased compared to WT mice at baseline and post-ischemia (<i>P</i> < 0.05). …”

When unbound to CRL4, BK channel α subunit is redirected to SCF^Fbxo7 for proteasomal degradation. by Tianyu Song (4797417)

PGRN deficiency results in decreased GCase activity in mouse tissues. by Xiaolai Zhou (3547520)

THP1 TET1 knockout cell line was generated using CRISPR/Cas9. by Fangfang Sun (2410654)

Cre recombinase<i>-</i>mediated activation of the RIαB allele in ES cells decreases PKA activity and forskolin-stimulated CRE-luciferase reporter expression. by Brandon S. Willis (353418)

The interaction of <i>F</i>. <i>novicida kpsF</i>::T20 mutant with macrophage-like cells showed a decrease in CFU recovery and the host cell monolayer undergoing cell death. by Taylor Chance (611108)

Decreased NK1.1^pos iNKT cell numbers in the peripheral organs of T cell-specific <i>Gfi1</i>-deficient mice. by Toshiaki Yasuoka (2827457)

SAHA treatment decreases HDAC2 protein levels but does not affect the protein levels of other class I and IIa HDACs – 2^nd trial. by Michal Mielcarek (195209)

<i>M</i>. <i>bovis</i> 0690::Tn mutant failed to elicit the recruitment of neutrophils into milk spaces. by Aga E. Gelgie (17661720)

Wnt5a expressing tumors demonstrate a decrease in markers of the basal tumor subtype. by Stephanie L. Easter (662168)

“…Values are means +/− standard error (n = 6 MMTV-Wnt1, 3 fields per tumor; n = 5 MMTV-Wnt1;MMTV-Wnt5a, 3 fields per tumor). MMTV-Wnt1;MMTV-Wnt5a tumors demonstrated a significant decrease in K6-expressing cells as measured by T-test (* = p<0.05).…”

Loss of mammary fitness and virulence by <i>M</i>. <i>bovis</i> 0690::Tn mutant. by Aga E. Gelgie (17661720)

CRISPR/Cas9-mediated deletion of <i>c-REL</i> results in a decreased proliferation of HeLa Kyoto cell accompanied by strongly reduced amounts of histone H2B. by Carsten Slotta (4326091)

“…<b>D:</b> Flow cytometric analysis of histone H2B-mCherry showed a strongly decreased amount of the H2B protein in 41.48% of <i>c-REL</i>^-/- HeLa Kyoto cells, which was observable in only 8.67% of HeLa Kyoto wt cells.…”