Inflammatory Adipokines Decrease Expression of Two High Molecular Weight Isoforms of Tropomyosin Similar to the Change in Type 2 Diabetic Patients by Stuart A. Savill (3129060)

“…The change in expression in HMW isoforms from TPM1 and TPM4 was replicated in THP1 cells treated with 1 ng/ml TNFα (0.10 and 0.12 v 1.00 respectively) or 10 ng/ml IL-1α (0.17 and 0.14 v 1.00 respectively). …”

Coverage of reference gene panel by assay A to E for reference samples. by Lizhi Yu (12476136)

Subjects:

Decreased THBS1 Protein Levels Translate into Reduced TGF-β Activity by Mark A Samols (30415)

Absence of BRDT leads to a global chromatin condensation and a decrease in the length of the SC of autosomal chromosomes. by Marcia Manterola (260674)

MiR-132-3p was downregulated in TGF-<i>β</i>1 stimulated Met-5A cells and miR-132-3p mimics and miR-132-3p inhibitor transfected Met-5A cells. by Yangyang Yin (14323701)

Subjects:

Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation - Fig 5 by Femke van Diggelen (6499112)

Avertin®-induced decrease in basal particle transport speed (PTS) remains unaffected in WT mice in the presence of TASK-1 inhibitors and in TASK-1 KO mice. by Ghulam Murtaza (2559319)

“…<p><b>(A)</b> Avertin® in the presence of anandamide did not decrease PTS significantly. …”

Binding of <i>PC3/Tis21</i> to the <i>Id3</i> promoter and corresponding decrease of <i>Id3</i> mRNA. by Stefano Farioli-Vecchioli (256006)

“…(<b>B</b>) ChIP analysis of <i>PC3</i> binding to the <i>Id3</i> promoter in PC12 cells, treated as shown in (<b>A</b>). A scheme above the graph describes the <i>Id3</i> gene and the promoter region analyzed, 700 nt 5′ to the transcription start. …”

Baseline sleep/wake characterizations of WT and W/W^v mice. by Sachiko Chikahisa (417256)

“…Amount of REM (bottom) was slightly decreased in W/W^v mice during the light phase (L; ZT0-12) but was not during the dark phase (D; ZT12-24). …”

IMQ-treated K14 mice had more stable skin inflammation. by Xuguo Wang (839264)

Acinetobactin biosynthetic mutants exhibit decreased maximal growth and growth rates, as well as an increased lag time relative to WT <i>A</i>. <i>baumannii</i> ATCC 179789 when gr... by Jessica R. Sheldon (4785675)

DHT increases whereas orchidectomy decreases the seminal vesicle weight in wild-type and SOD1-G93A mice. by Young-Eun Yoo (323357)

“…Conversely, orchidectomy decreased the seminal vesicle weight in both WT mice (28.4±13 mg, <i>p</i><0.0001) and SOD1 mice (20.8±3.5 mg, <i>p</i><0.0001) compared with control WT and SOD1 mice, respectively. …”

HRMECs treated with SUZ12 siRNA demonstrate increased miR-200b expression, decreased VEGF expression and decreased endothelial branching. by Michael Anthony Ruiz (726055)

“…However, transfection of SUZ12 siRNA significantly reduced endothelial branching compared to HG+control siRNA. [NG+control siRNA = 5mM D-glucose + 100nM control siRNA, HG+control siRNA = 25mM D-glucose + 100nM control siRNA, HG+EZH2 siRNA = 25mM D-glucose + 100nM EZH2 siRNA, HG+SUZ12 siRNA = 25mM + 100nM SUZ12 siRNA; identical letters represent groups that are not significantly different; p < 0.05; n = 6; data expressed as mean ± SEM, normalized to U6 or β-actin and expressed as a fold change of NG+control siRNA].…”

Delphinidin alters VEGF-A splicing to increase VEGF-A₁₆₅b and decrease total VEGF-A expression. by Megan Stevens (3964886)

“…<p><b>A)</b> Treatment of podocytes with delphinidin chloride (10 μg/ml) under normal glucose (NG; 5 mM glucose + 25 mM mannitol) and high glucose (HG; 30 mM glucose, 1 ng/ml TNFα, 1 ng/ml IL-6, and 100 nM insulin) for 48 hrs increased the protein expression of VEGF-A₁₆₅b relative to total VEGF-A₁₆₅ (quantified in <b>B</b>; *p<0.05 vs NG, †p<0.05 vs HG; n = 3 biological repeats; One-way ANOVA with Bonferroni post-hoc test for comparison between pairs; <b>A</b>—the same blot was first probed with VEGF-A₁₆₅b before stripping and reprobing with panVEGF-A). …”

Apoptosis inhibitor of macrophage depletion decreased M1 macrophage accumulation and the incidence of cardiac rupture after myocardial infarction in mice by Shohei Ishikawa (4583068)

“…MMP-2 and 9 activity levels in the infarcted myocardium were significantly lower in AIM^{<b>‒/‒</b>} mice than in WT mice.</p><p>Conclusions</p><p>These findings suggest that AIM depletion decreases the levels of M1 macrophages, which are a potent source of MMP-2 and 9, in the infarcted myocardium in the acute phase after MI by promoting macrophage apoptosis, and leads to a decrease in the incidence of cardiac rupture and improvements in survival rates.…”

related to Fig 5: Glycolysis critically regulates the acidification of phagosome and the assembly of v-ATPase complex. by Saray Gutiérrez (11473528)

WT and IFN-γR^-/- have similar amounts of cytokines and frequencies of immune cells in the brain following infection. by Catherine M. Kerr (21492574)

Prolonged transforming growth factor (TGF)-βtreatment induced a decrease in total Smad2 and/or Smad3 in many cell strains by Kimberly A Brown (26546)

Mass Spectrometry Experiment 1: Comparison of Mito Matrix and Vpu WT and mutants. by Charlotte A. Stoneham (10819125)

NBCe1 protein expression regulation by D₁-like (D₁R and D₅R) dopamine receptor agonist in hRPTCs carrying wild-type (WT) <i>SLC4A5</i>. by John J. Gildea (845025)

“…<p>NBCe1 protein expression is decreased following an increase in intracellular sodium (↑Na⁺) (10 μmol monensin/L, 24 h) (N = 4, *P<0.001 vs VEH, one-way ANOVA, Tukey’s test) in WT <i>SLC4A5</i> hRPTC. …”