Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Ariadne is a non-hallucinogenic analog in the phenylalkylamine chemical class of psychedelics that is closely related to an established synthetic hallucinogen, 2,5-dimethoxy-4-methyl-amphetamine (DOM), differing only by one methylene group in the α-position to the amine. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Ariadne is a non-hallucinogenic analog in the phenylalkylamine chemical class of psychedelics that is closely related to an established synthetic hallucinogen, 2,5-dimethoxy-4-methyl-amphetamine (DOM), differing only by one methylene group in the α-position to the amine. …”

Dcp1a protein levels are decreased by KapB expression and Torin treatment. by Carolyn-Ann Robinson (13297009)

Activating cAMP synthesis decreases liberation of propionyl-CoA from cholesterol. by Kaley M. Wilburn (12060476)

Illustration of the electrophysiological response (steady-state evoked potential) when stimulating with 8 Hz and 36 Hz in, respectively, a young and an old adult from our sample. by Anna Horwitz (771335)

Subjects:

Recombinant CCR5-T4L acts as a HIV-1 co-receptor and down-regulates WT-CCR5 expression on the 3T3T4 cell surface. by Qingwen Jin (767337)

“…WT-CCR5 was used as a positive control. B) CCR5 expression on the cell surface was confirmed using FACS. …”

Diverse stress conditions trigger a rapid and dramatic decrease in miR-520b-3p and a corresponding increase in ATF5 mRNA over time in HeLa cells. by Kari A. Gaither (9046190)

Acetaldehyde decrease/eliminates C/EBP alpha binding to CTSL promoter sequence. by Riyaz A. Mir (350175)

Genes encoding proteins involved in other metabolic processes differentially expressed in liver of <i>Fmo5</i>^<i>-/-</i> mice compared with WT mice. by Ian R. Phillips (5074121)

Genes encoding proteins involved in amino acid metabolism differentially expressed in liver of <i>Fmo5</i>^<i>-/-</i> mice compared with WT mice. by Ian R. Phillips (5074121)

Infection of CD133+ humanized mice resulted in decrease in pathogenicity in HTLV-1-CTCF infected mice. by Ancy Joseph (5634794)

Decreased Muscle Strength of Knee Flexors Is Associated With Impaired Muscle Insulin Sensitivity in Non-Diabetic Middle-Aged Japanese Male Subjects by Yuki Someya (770709)

Absence of BRDT leads to a global chromatin condensation and a decrease in the length of the SC of autosomal chromosomes. by Marcia Manterola (260674)

Substrate translocation via Mep2^H194E induces a pH decrease. by Ana Sofia Brito (8463537)

Inclusion of SRRM4-regulated exons is decreased in tumors and cancer cell lines. by Sarah A. Head (6066398)

“…Red points are exons with PSI decreasing by at least 5% in at least 1 tumor type. …”

Cell viability as measured by MTT absorbance (abs) at 570nm, LDH release and intracellular NAD levels of microglial cells after 48 hour incubation in pooled, non heat inactivated a... by Tharusha Jayasena (704509)

GCase substrate levels are altered in the brain and liver of homozygous <i>GBA1</i> D409V KI mice. by Nicole K. Polinski (10947787)

Average awakening citation-intensity <i>c</i>_<i>a</i> for SN-SNPRs and SB-nonSNPRs with <i>s</i> = 5. by Anthony F. J. van Raan (7517696)

Lysosome function, as assessed by Lamp1 levels, are unchanged in the <i>GBA1</i> D409V KI mouse model. by Nicole K. Polinski (10947787)

Loss of virulence in the SIN kinase mutants is characterized by decreased fungal burden and host response to infection. by Ana Camila Oliveira Souza (8180958)

“…<p><b>A)</b> Analysis of fungal burden by qPCR at day +4 post inoculation. …”