Showing 641 - 660 results of 99,506 for search '(( 5 wt decrease ) OR ( 5 ((non decrease) OR (((nn decrease) OR (a decrease)))) ))', query time: 1.38s Refine Results
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    Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology by Laurence J. Howe (5579186)

    Published 2018
    “…Where evidence was found of genetic overlap, we used bidirectional Mendelian randomization (MR) to test the hypothesis that genetic liability to nsCL/P is causally related to implicated facial phenotypes. Across 5,804 individuals of European ancestry from two studies, we found strong evidence, using PRS, of genetic overlap between nsCL/P and philtrum width; a 1 S.D. increase in nsCL/P PRS was associated with a 0.10 mm decrease in philtrum width (95% C.I. 0.054, 0.146; P = 2x10<sup>-5</sup>). …”
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