Data Sheet 1_Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease.xlsx by Demos Kynigopoulos (12420457)

“…</p>Methods<p>We investigated the effects of two FDA-approved metabolic agents—Alirocumab, a PCSK9 inhibitor that lowers LDL cholesterol, and Gliclazide, a sulfonylurea that enhances insulin secretion—in male 5xFAD mice, a transgenic model of AD. …”

Supplementary file 1_Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease.docx by Demos Kynigopoulos (12420457)

“…</p>Methods<p>We investigated the effects of two FDA-approved metabolic agents—Alirocumab, a PCSK9 inhibitor that lowers LDL cholesterol, and Gliclazide, a sulfonylurea that enhances insulin secretion—in male 5xFAD mice, a transgenic model of AD. …”

Glial 5-HT_2a receptors are necessary and rate limiting for experience-dependent synaptic glomeruli pruning. by Vanessa Kay Miller (19775496)

“…The Or42a OSN innervation volume with glial <i>5-HT</i>_<i>2A</i><i>R</i> OE is very significantly decreased in comparison to the control EB condition (<i>p</i> = 4.64 × 10⁻¹⁰). …”

Subnetwork of core DE genes with ≥5.0 degree and a fold change of ≥2.0 (50 nodes and 97 edges). by Reena Arora (1464781)

Continuous bioluminescence images after different days of transplanted Ad5-TGF transfected BMSCs into myocardial infarction rats (A). by Zhijun Pei (402179)

Degradation of a VX Analogue: First Organometallic Reagent To Promote Phosphonothioate Hydrolysis Through Selective P−S Bond Scission by Louis Y. Kuo (1915309)

“…We report the first case of a metal complex that degrades a neurotoxin mimic under extremely mild conditions (pH 6.8, room temperature). …”

Image_5_RETRACTED: The Design, Characterizations, and Tumor Angiogenesis Inhibition of a Multi-Epitope Peptibody With bFGF/VEGFA.TIF by Ligang Zhang (830488)

Registration-based receptive field comparisons show a quantitative match between SAILnet and macaque V1 RF shapes. by Joel Zylberberg (340947)

“…<p>(<b>A</b>) For illustration purposes, we show 100 of the 250 macaque V1 receptive fields (courtesy of D. …”

Temporal trend of ∑DDT levels in osprey eggs in different study areas and all areas combined (lower graph). by Matti Viluksela (321291)

“…∑DDT concentrations decreased significantly in the whole dataset (annual decrease 8.1%) and in all study areas (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0308227#pone.0308227.g015" target="_blank">Fig 15</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0308227#pone.0308227.t002" target="_blank">Table 2</a>). …”

Image5_Disturbed flow regulates protein disulfide isomerase A1 expression via microRNA-204.TIF by Leonardo Y. Tanaka (18306715)

“…Our search identified that miR-204-5p and miR-211-5p (miR-204/211), two broadly conserved miRNAs, share PDIA1 as a potential target. …”

Table_1_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.XLSX by Chaoqin Shen (3763807)

“…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”

Table_2_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.XLSX by Chaoqin Shen (3763807)

“…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”

Table_5_Living at the Edge: Increasing Stress for Plants 2–13 Years After the Retreat of a Tropical Glacier.DOCX by Fabien Anthelme (475650)

Image_2_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.JPEG by Chaoqin Shen (3763807)

“…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”

Table_3_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.XLSX by Chaoqin Shen (3763807)

“…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”

Table_5_Causal relationship between telomere length and risk of intracranial aneurysm: a bidirectional Mendelian randomization study.XLSX by Bangjie Xu (18133135)

“…</p>Conclusion<p>There may exist a potential correlation between longer telomere length and a decreased likelihood of intracranial aneurysms within the European population. …”

Image_1_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.JPEG by Chaoqin Shen (3763807)

“…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”

Image_5_Birth Weight and Subsequent Risk of Total Leukemia and Acute Leukemia: A Systematic Review and Meta-Analysis.jpg by Hailuo Che (11470654)

Table_5_Dysregulated miRNAome and Proteome of PPRV Infected Goat PBMCs Reveal a Coordinated Immune Response.XLSX by Alok Khanduri (5999219)

“…These include miR-664, miR-2311, miR-2897, miR-484, miR-2440, miR-3533, miR-574, miR-210, miR-21-5p, and miR-30. miR-664 and miR-484 with proviral and antiviral activities, respectively, were upregulated in PPRV infected PBMCs. miR-210 that inhibits apoptosis was downregulated. miR-21-5p that decreases the sensitivity of cells to the antiviral activity of IFNs and miR-30b that inhibits antigen processing and presentation by primary macrophages were downregulated, indicative of a strong host response to PPRV infection. miR-21-5p was found to be inhibited on IPA upstream regulatory analysis of RNA-sequencing data. …”

Image2_Osteogenesis-Related Long Noncoding RNA GAS5 as a Novel Biomarker for Osteonecrosis of Femoral Head.TIFF by Guanzhi Liu (11016411)

“…In addition, the lncRNA GAS5 expression level significantly decreased in the ONFH rat model group.…”