The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…After 24 h, bortezomib and carfilzomib decreased worm motility by more than 85% and endogenous proteasome activity by >75%, and after 72 h, they increased caspase activity by >4.5-fold. …”

The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…After 24 h, bortezomib and carfilzomib decreased worm motility by more than 85% and endogenous proteasome activity by >75%, and after 72 h, they increased caspase activity by >4.5-fold. …”

The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…After 24 h, bortezomib and carfilzomib decreased worm motility by more than 85% and endogenous proteasome activity by >75%, and after 72 h, they increased caspase activity by >4.5-fold. …”

Circulating TRAIL Shows a Significant Post-Partum Decline Associated to Stressful Conditions by Giorgio Zauli (191939)

“…</p> <h3>Conclusions</h3><p>Stressful partum conditions and elevated CRP levels are associated with a decrease of circulating TRAIL.</p> </div>…”

Repetitive stress induces a reduction in sound-evoked activity that develops as the stressor becomes chronic. by Ghattas Bisharat (20706928)

“…<p>(a) Change of tone-evoked activity over time. Comparison of tone-evoked activity after a day and 5 days of stress to baseline. …”

Cost-effectiveness of maternal influenza immunization in Bamako, Mali: A decision analysis by Evan W. Orenstein (130613)

Dynamics of Premixed Hydrogen-Air Flames in Microchannels with a Wall Temperature Gradient by Aswathy Nair (753246)

“…Detailed studies on the formation of flames with repetitive extinction and ignition (FREI) mode have been carried out for a 0.75-mm diameter tube with fixed conditions of flow velocity of 10 cm/s and Φ = 0.5–1.0 with wall temperature linearly varying from 300 K to 960 K. …”

Neoadjuvant chemotherapy for muscle invasive bladder cancer: a nationwide investigation on survival by Beth Russell (5095202)

“…This study calculated 5-year survival and risk of bladder cancer (BC)-specific and overall death by Cox proportional hazard models for the study cohort and a propensity score (PS) matched cohort.…”

A standardized post-cesarean analgesia regimen reduces postpartum opioid use by Melissa F. Meyer (11339199)

“…</p> <p>To determine if implementation of a standardized postoperative analgesic regimen decreases opioid use following cesarean birth.…”

DataSheet_1_A Strigolactone Signal Inhibits Secondary Lateral Root Development in Rice.pdf by Huwei Sun (4541788)

“…Higher expression of DR5::GUS and more secondary LR primordia were found in the d mutants than in the WT plants. …”

The QSAR-search of effective agents towards coronaviruses applying the Monte Carlo method by A.A. Toropov (6732974)

“…A collection of possible biologically active compounds, constructed using data on the above molecular features which are statistically reliable promoters of increase or decrease of the activity, is presented.…”

Dataset for: The thermodynamic basis of glucose stimulated insulin release: a model of the core mechanism. by David F Wilson (4048306)

“…Applied to the reported glucose concentration dependent release of insulin by perifused islet preparations (4), the model predicts that the dependence of insulin release on [ADP] is strongly cooperative with a threshold of about 30 µM and a negative Hill coefficient near -5.5. …”

Data_Sheet_2_Normal distribution of H3K9me3 occupancy co-mediated by histone methyltransferase BcDIM5 and histone deacetylase BcHda1 maintains stable ABA synthesis in Botrytis cine... by Zhao Wei (3095598)

“…In addition, we found that the cause of the decreased ABA production in the ΔBcdim5 and ΔBchda1 mutants was due to cluster gene repression caused by the emergence of hyper-H3K9me3 in the ABA gene cluster. …”

Data_Sheet_3_Normal distribution of H3K9me3 occupancy co-mediated by histone methyltransferase BcDIM5 and histone deacetylase BcHda1 maintains stable ABA synthesis in Botrytis cine... by Zhao Wei (3095598)

“…In addition, we found that the cause of the decreased ABA production in the ΔBcdim5 and ΔBchda1 mutants was due to cluster gene repression caused by the emergence of hyper-H3K9me3 in the ABA gene cluster. …”

Data_Sheet_1_Normal distribution of H3K9me3 occupancy co-mediated by histone methyltransferase BcDIM5 and histone deacetylase BcHda1 maintains stable ABA synthesis in Botrytis cine... by Zhao Wei (3095598)

“…In addition, we found that the cause of the decreased ABA production in the ΔBcdim5 and ΔBchda1 mutants was due to cluster gene repression caused by the emergence of hyper-H3K9me3 in the ABA gene cluster. …”

RbmB digests VPS <i>in vitro</i>. by Ranjuna Weerasekera (20371182)

“…Increasing amounts of RbmB show a decrease in the aggregates and increase in free Bap1, suggesting cleavage of VPS into small fragments. …”

A prospective study of the influence of the skeleton on calcium mass transfer during hemodialysis by Patricia Taschner Goldenstein (5570870)

“…</p><p>Results</p><p>Calcium mass transfer varied widely among patients in each study phase with a median of -89.5, -76.8 and -3 mmol using d[Ca] 1.25 mmol/L, -106, -26.8 and 29.7 mmol using d[Ca] 1.50 mmol/L, and 12.8, -14.5 and 38 mmol using d[Ca] 1.75 mmol/L during pre-PTX, early post-PTX and late post-PTX, respectively, which was significantly different among d[Ca] (p = 0.0001) and among phases (p = 0.040). …”

Metrics for GO based protein semantic similarity: a systematic evaluation-2 by Catia Pesquita (46491)

“…<p><b>Copyright information:</b></p><p>Taken from "Metrics for GO based protein semantic similarity: a systematic evaluation"</p><p>http://www.biomedcentral.com/1471-2105/9/S5/S4</p><p>BMC Bioinformatics 2008;9(Suppl 5):S4-S4.…”

Supplementary file 1_Ivarmacitinib reduces the need for adding/escalating medications in moderate-to-severe rheumatoid arthritis patients: a post hoc analysis from a phase III tria... by Huaxiang Liu (322464)

“…</p>Methods<p>This was a post hoc study from a phase III clinical trial (NCT04333771). …”

SCP-induced inhibition of PVN neurons is prevented by a selective CRF-R2 antagonist. by Chun-Ping Chu (287953)

“…B, Antisauvagine-30, a selective CRF-R2 antagonist (30 nM), did not affect the evoked spike firing of the neuron (upper), but abolished the SCP-induced decrease in spike firing (lower). …”