Analysis of purine and pyrimidine metabolism from <i>R. alamii</i> cells grown with no cadmium (white bars) or 2 mg.L-1 of cadmium as cadmium nitrate. by Mathieu Schue (197145)

“…<p>Masses of the purine based cyclic nucleotides were additionally detected from the Cd²⁺ treated samples. 2,3&3,5-cyclic-AMP from the wt and 2,3&3,5-cyclic-GMP were detectable according to the FTMS measurements and use of MassTrix for data interpretation. …”

Antitumor Activity and Induction of TP53-Dependent Apoptosis toward Ovarian Clear Cell Adenocarcinoma by the Dual PI3K/mTOR Inhibitor DS-7423 by Tomoko Kashiyama (162572)

“…In mouse xenograft models, DS-7423 suppressed the tumor growth of OCCA in a dose-dependent manner. Flow cytometry analysis revealed a decrease in S-phase cell populations in all the cell lines and an increase in sub-G1 cell populations following treatment with DS-7423 in six of the nine OCCA cell lines tested. …”

Data_Sheet_1_Biological Characterization of Hepatitis B virus Genotypes: Their Role in Viral Replication and Antigen Expression.docx by María Mercedes Elizalde (5184335)

“…Genotype A2 expressed the lowest pgRNA levels, with a 70-fold decrease in relation to the other genotypes (p<0.0001), while genotype B2 showed the lowest Precore RNA levels, with a 100-fold reduction compared to genotype A2 (p<0.0001). …”

Antigen B from <i>Echinococcus granulosus</i> enters mammalian cells by endocytic pathways by Edileuza Danieli da Silva (5176148)

“…AgB uptake was observed in four different cell lines, NIH-3T3, A549, J774 and RH. Inhibition of caveolae/raft-mediated endocytosis causes about 50 and 69% decrease in AgB internalization by RH and A549 cells, respectively. …”

The Effect of Aerobic Exercise on Intrahepatocellular and Intramyocellular Lipids in Healthy Subjects by Andrea Egger (107540)

“…Two hours aerobic exercise resulted in a significant decrease in IMCL (−22.6±3.3, % from baseline) and increase in IHCL (+34.9±7.6, % from baseline). …”

Spiking activity of dentate gyrus granule cells during exploratory behaviour evokes large short-term plasticity at mossy fiber synapses <i>in vitro</i>. by Anja Gundlfinger (366062)

“…A large dynamic range of response amplitudes is apparent with amplitudes generally largest with ISIs ranging from 50–1000 ms. …”

Hormonal regulation of structural changes in Sema4D and Plexin-B1. by Takuji Ito (566032)

“…<p>(A–D) To investigate whether estrogen induces structural changes in Sema4D, Plexin-B1, or both, ovariectomized mice receive daily subcutaneous injections (s.c.) of 17β-estradiol (E2, 0.1 µg/kg) until 5 weeks after birth. As expected, both soluble Sema4D and active Plexin-B1 are detected in vaginal tissue from sham-operated 5-week-old female WT mice (Sema4D+/+). …”

Generation of post-mitotic neurons requires NRG1-II. by Tomomi Sato (301255)

“…<i>4neurog1</i>:<i>nRFP</i>) at 50 hpf. Scale bar, 10 μm. <b>C</b>. Quantification of <i>neurod</i>:EGFP intensity in the OT for the experiment shown in A (mean ± s.e.m.; **<i>P</i> < 0.01; n = 4 per group). …”

Characterizing suboptimal child passenger safety practices in crashes with fatalities: Child, driver, vehicle, neighborhood, and policy factors by Arthi S. Kozhumam (14176683)

“…We sought to identify child, driver, vehicle, neighborhood, and policy-level factors associated with suboptimal child passenger safety practices in motor vehicle collisions (MVCs) with a fatality. …”

<i>sml1Δ</i> regulation of mitotic recombination. by James D. Cauwood (481139)

“…</b> Effect of <i>sml1Δ</i> on IC/IS bias. Fraction of 5FOA^R colonies that had undergone <i>URA3</i> inactivation via an IC/IS mediated event ^a The fraction in <i>sml1Δ</i> at each locus was normalized to the corresponding value in WT (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003931#pgen-1003931-g003" target="_blank">Figure 3E</a>). …”

Improvement of Short-Circuit Tolerance of Garnet Type Solid Electrolyte Li_6.4La₃Zr_1.4Ta_0.6O₁₂ by Li₂WO₄... by Yuya KONO (21259284)

“…Simultaneous addition of 4 wt% LWO and 2 wt% Al₂O₃ gave relatively larger grains (5–20 µm) with very few voids, and a very high relative density of 99.3 % was obtained. …”

Graphene Oxide Grid Preparation by Thomas G. Martin (2619529)

“…</p> <p>Areas of criticism are a slight decrease in the electron transparency compared to graphene and a variance in support layer thickness due to the possible deposition of multiple layers of flakes in a random manner. …”

Responses to growth factors. by Kazunari Mouri (265029)

IL-1β depletion and IL-1 receptor antagonist treatment alleviated the neutrophilic inflammation. by Wen-Cheng Chao (2817868)

“…<i>marinum</i>-infected <i>Ncf1</i>^<i>-/-</i> mice and WT mice on day-5 with and without IL-1β depletion by a monoclonal antibody directed against IL-1β (150μg on day-1). …”

Smad1 target genes repressed and activated in senescence. by Atsushi Kaneda (198186)

“…<p>(<i>A</i>) Repression of Smad1 target genes by H3K27me3. 838 Smad1 target genes in MEF were sorted by fold expression change between MEFp2 and mean of RasV12 day3, 7, and 10 (<i>Expression column</i>). 50 genes showed increase of H3K27me3 reads in RasV12 by 0.4 or more (↑<i>column</i>), and were significantly enriched downward (*P = 0.004, Kolmogorov-Smirnov test), i.e. repressed. …”

Video1_The mechanisms of potassium loss in acute myocardial ischemia: New insights from computational simulations.AVI by Jose M. Ferrero (6705797)

“…In order to investigate these mechanisms, we developed a novel computational model of acute myocardial ischemia which couples a) an electrophysiologically detailed human cardiomyocyte model that incorporates modifications to account for ischemia-induced changes in transmembrane currents, with b) a model of cardiac tissue and extracellular K⁺ transport. …”

DataSheet1_The mechanisms of potassium loss in acute myocardial ischemia: New insights from computational simulations.docx by Jose M. Ferrero (6705797)

“…In order to investigate these mechanisms, we developed a novel computational model of acute myocardial ischemia which couples a) an electrophysiologically detailed human cardiomyocyte model that incorporates modifications to account for ischemia-induced changes in transmembrane currents, with b) a model of cardiac tissue and extracellular K⁺ transport. …”

Loss of <i>bmm</i> function in the somatic cells of the gonad with an independent GAL4 line affects whole-body triglyceride breakdown in males but not females. by Lianna W. Wat (8339454)

“…(C) Between 0 and 12 hours STV, the magnitude of triglyceride breakdown in <i>tj>UAS-bmm-RNAi</i> was similar to <i>tj>+</i> and <i>+>UAS-bmm-RNAi</i> control males; however, between 12 and 24 hours STV, there was no significant decrease in triglyceride levels in <i>tj>UAS-bmm-RNAi</i> males, in contrast to <i>tj>+</i> and <i>+>UAS-bmm-RNAi</i> control males, in which we observed a significant decrease in triglyceride storage STV (<i>p</i> = 9.7 × 10⁻⁴, 0.0018, and 0.099 for 0–12 hours and 0.37, 1.9 × 10⁻⁵, and 0.028 for 12–24 hours, respectively; one-way ANOVA followed by Tukey HSD test). …”

Image_1_Modulation of low-dose ozone and LPS exposed acute mouse lung inflammation by IF1 mediated ATP hydrolysis inhibitor, BTB06584.tif by Pahul Singh (14781409)

“…Ozone and LPS exposure induced lung neutrophil and eosinophil recruitment as measured by respective peroxidase (MPO and EPX) assays, systemic leukopenia, increased levels of lung vascular neutrophil regulatory chemokines such as CXCL5, SDF-1, CXCL13 and a decrease in immune-regulatory chemokines such as BAL IL-10 and CCL27. …”

Image_2_Modulation of low-dose ozone and LPS exposed acute mouse lung inflammation by IF1 mediated ATP hydrolysis inhibitor, BTB06584.tif by Pahul Singh (14781409)

“…Ozone and LPS exposure induced lung neutrophil and eosinophil recruitment as measured by respective peroxidase (MPO and EPX) assays, systemic leukopenia, increased levels of lung vascular neutrophil regulatory chemokines such as CXCL5, SDF-1, CXCL13 and a decrease in immune-regulatory chemokines such as BAL IL-10 and CCL27. …”