<i>In silico</i> screening identifies doxazosin as a novel agonist for EphA2 receptor. by Aaron Petty (143170)

“…MDA-231-A2 cells were treated with Compounds 1–11 (50 µM in 0.2% DMSO) for 30 minutes and cell lysates were subject to immunoblot for phosphorylated EphA/B kinases (pEphA/B) and total EphA2. …”

Data file. by Maryam Khalaji (21743611)

“…The results showed that mental fatigue significantly decreased QE duration (Mean difference = −138.75 ms, p = .0009) and fixation duration (Mean difference = 67.50 ms, p = .001), indicating a detrimental effect on sustained attention. …”

FLIM FRET efficiency of: (A) αA-crystallin (B) WT αB-crystallin, their deamidated and domain mutants. by Ekta Tiwary (836674)

RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity by Brandon L. Probst (727964)

“…Here, we characterized the in vitro antioxidant, anti-inflammatory, and anticancer activities of RTA 408, a novel AIM that is currently being evaluated in patients with advanced malignancies. …”

Temperature-dependence of A) the ratio of rate constants k1/k2. The presence of the DII loop made the first rate constant ratio less affected by temperature changes, as seen for <i... by Roberto F. Delgadillo (843498)

NG2-expressing pericytes are disorganized in the cardiac vasculature of <i>Pdgfd</i>^<i>-/-</i> mice. by Hanna Gladh (2586991)

“…(O) <i>Pdgfd</i>^<i>-/-</i> pericyte with thick, rough, processes ending abruptly. (A-E) age 12 weeks and (E-O) age 15–17 weeks. Scale bars 20 or 50 μm. …”

On a steepening environmental gradient, a sharp and stable range margin forms near the expansion threshold. by Jitka Polechová (5400749)

“…(<b>b</b>) As the environmental gradient steepens, the frequency of limited adaptation within the metapopulation increases (black and grey), and hence neutral variation decreases (blue). The black line gives the proportion of demes with limited adaptation after 50,000 generations, when the range margin appears stable; grey gives the proportion after 40,000 generations (depicted is an average over a sliding window of 15 demes). …”

N⁶-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKT-mTOR pathway drove the development of pulmonary fibrosis induced by nanoscale carbon blac... by Bin Han (45760)

“…We found that both of m⁶A modifications of pri-miRNA-126 and its binding with DGCR8 were decreased after CB treatment, which resulted in the reduction of mature miRNA-126 accompanied by accumulation of unprocessed pri-miRNA-126. …”

Importance of the features. by Zhi Jiang (269212)

Variable selection in the RF algorithm. by Zhi Jiang (269212)

DataSheet_1_A20 Establishes Negative Feedback With TRAF6/NF-κB and Attenuates Early Brain Injury After Experimental Subarachnoid Hemorrhage.zip by Hong-Ji Deng (11182902)

“…<p>Nuclear factor (NF)-κB–ty -50mediated neuroinflammation plays a crucial role in early brain injury (EBI) after subarachnoid hemorrhage (SAH). …”

Two food choices profiles at Time 1 and Time 2. by Juan Cao (3145449)

“…</p><p>Method</p><p>Two-wave longitudinal data was collected from a sample of 431 Chinese college students (Mean baseline age = 19.15 ± 0.61 years; 45.7% male). …”

Healthy control group HR and CBF changes. by Liuchuang Wei (19273099)

“…Computational results revealed that hypovolemia reduces cerebral blood flow by approximately 100 mL/min due to a 30% decrease in blood volume, while vascular dysfunction—marked by a 50–100% increase in arterial stiffness—further diminishes cardiac output and cerebral perfusion. …”

List of abbreviations used in this paper. by Liuchuang Wei (19273099)

“…Computational results revealed that hypovolemia reduces cerebral blood flow by approximately 100 mL/min due to a 30% decrease in blood volume, while vascular dysfunction—marked by a 50–100% increase in arterial stiffness—further diminishes cardiac output and cerebral perfusion. …”

Estimation of the CO and CBF. by Liuchuang Wei (19273099)

“…Computational results revealed that hypovolemia reduces cerebral blood flow by approximately 100 mL/min due to a 30% decrease in blood volume, while vascular dysfunction—marked by a 50–100% increase in arterial stiffness—further diminishes cardiac output and cerebral perfusion. …”

Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing <i>Iso</i>combretastatins and Phenstatins as Antitumor Agents by Yanqing Pang (4386715)

“…Most of these selenium containing hybrids exhibited potent cytotoxicity against a panel of cancel cell lines, with IC₅₀ values in the submicromolar concentration range. …”

Transition from a Nonbonding to a Bonding Interaction in a Tetranuclear [Mo₂]₂(μ-OR)₄ Cluster by F. Albert Cotton (1781341)

“…The sharp signals in the NMR spectrum at −50 °C and the lack of an EPR signal suggest that this species is diamagnetic and that a four-center, two-electron bond is formed in the cyclometallic Mo₄ cluster. …”

GSTM3 A/B Polymorphism and Risk for Head and Neck Cancer: A Meta-Analysis by Yu Xu (52257)

“…Stratification by tumor site indicated that the GSTM3 polymorphism was associated with a decreased risk of laryngeal cancer under recessive model and homozygote comparison (OR = 0.52, 95%CI: 0.30–0.89; and OR = 0.50, 95%CI: 0.29–0.87, respectively); By stratifying source of control, decreased cancer risk was observed in hospital-based population under all genetic models (OR = 0.67, 95%CI: 0.56–0.81 for the dominant model; OR = 0.66, 95%CI: 0.46–0.95 for the recessive model; OR = 0.55, 95%CI: 0.37–0.83 for the homozygote comparison model, and OR = 0.70, 95%CI: 0.58–0.84 for the heterozygote comparison model).…”

Discovery of Novel Imidazo[4,5‑<i>c</i>]quinoline Derivatives to Treat Inflammatory Bowel Disease (IBD) by Inhibiting Multiple Proinflammatory Signaling Pathways and Restoring Inte... by Xuewu Liang (3071676)

“…Especially, lead compound <b>8l</b> showed potent inhibitory activities against interferon-stimulated genes (IC₅₀: 3.3 nM) and NF-κB pathways (IC₅₀: 150.7 nM) and decreased the release of various proinflammatory factors at the nanomolar level, including IL-6, IL-8, IL-1β, TNF-α, IL-12, and IFN-γ. …”

The effects of variations in coagulation potential on atherogenesis in a spontaneous atherosclerosis model at 35 weeks on a regular chow diet. by Julian I. Borissoff (280594)