Image_2_The novel chimeric multi-agonist peptide (GEP44) reduces energy intake and body weight in male and female diet-induced obese mice in a glucagon-like peptide-1 receptor-depe... by James E. Blevins (11405813)

“…We hypothesized that GEP44 reduces energy intake and BW primarily through a GLP-1R dependent mechanism. To test this hypothesis, GLP-1R^+/+ mice and GLP-1R null (GLP-1R^-/-) mice were fed a high fat diet for 4 months to elicit diet-induced obesity prior to undergoing a sequential 3-day vehicle period, 3-day drug treatment (5, 10, 20 or 50 nmol/kg; GEP44 vs the selective GLP-1R agonist, exendin-4) and a 3-day washout. …”

Image_1_The novel chimeric multi-agonist peptide (GEP44) reduces energy intake and body weight in male and female diet-induced obese mice in a glucagon-like peptide-1 receptor-depe... by James E. Blevins (11405813)

“…We hypothesized that GEP44 reduces energy intake and BW primarily through a GLP-1R dependent mechanism. To test this hypothesis, GLP-1R^+/+ mice and GLP-1R null (GLP-1R^-/-) mice were fed a high fat diet for 4 months to elicit diet-induced obesity prior to undergoing a sequential 3-day vehicle period, 3-day drug treatment (5, 10, 20 or 50 nmol/kg; GEP44 vs the selective GLP-1R agonist, exendin-4) and a 3-day washout. …”

Transfection efficiency corrected ³H-gemcitabine uptake in HEK293 (A), AsPC-1 (B), and MIA PaCa-2 (C) cells with or without transfection of hCNT3 cDNA. by Robert J. Paproski (282968)

“…Uptake values were corrected for transfection efficiency as described in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056423#s2" target="_blank">methods</a> section. …”

Gene expression of <i>Iex-1</i> and <i>Vegf-A</i> by qRT-PCR in outflow vein of AVF seven days after adventitial delivery of hydrogel alone, hydrogel with nanoparticle PLGA without... by Akshaar Brahmbhatt (551498)

DataSheet1_Pharmacokinetic herb-drug interactions: Altered systemic exposure and tissue distribution of ciprofloxacin, a substrate of multiple transporters, after combined treatmen... by Ziqiang Li (247218)

“…</p><p>Results: Concurrent use of PCE substantially reduced circulating CIP (approximately 40%–50%) in humans and rats, while CIP hardly changed circulating GA and PCA. …”

DataSheet2_Pharmacokinetic herb-drug interactions: Altered systemic exposure and tissue distribution of ciprofloxacin, a substrate of multiple transporters, after combined treatmen... by Ziqiang Li (247218)

“…</p><p>Results: Concurrent use of PCE substantially reduced circulating CIP (approximately 40%–50%) in humans and rats, while CIP hardly changed circulating GA and PCA. …”

Light-intensity dependence of net oxygen production and consumption, as measured with a membrane-inlet mass spectrometer (MIMS), of wild type <i>Synechocystis</i>, its ΔOx and ΔFlv... by R. Milou Schuurmans (798363)

“…Experiments with <i>Synechocystis</i> and its mutant derivatives were conducted at 18°C and <i>Chlorella</i> at 30°C. ●, oxygen evolution measured as an increase in the concentration of ³²O₂; ◊, oxygen uptake measured as a decrease in the concentration of ³⁶O₂; Δ, net rate of photosynthesis (i.e. rate of net oxygen evolution + rate of oxygen uptake). …”

DataSheet1_Greater than recommended stiffness and power setting of a stance-phase powered leg prosthesis can improve step-to-step transition work and effective foot length ratio du... by Joshua R. Tacca (18067213)

“…People with TTA using a stance-phase powered prosthesis (e.g., BiOM, Ottobock, Duderstadt, Germany) walk with increased AL_trail W_pos and potentially decreased magnitude of UL_lead W_neg compared to a passive-elastic prosthesis. …”

DataSheet4_Greater than recommended stiffness and power setting of a stance-phase powered leg prosthesis can improve step-to-step transition work and effective foot length ratio du... by Joshua R. Tacca (18067213)

“…People with TTA using a stance-phase powered prosthesis (e.g., BiOM, Ottobock, Duderstadt, Germany) walk with increased AL_trail W_pos and potentially decreased magnitude of UL_lead W_neg compared to a passive-elastic prosthesis. …”

DataSheet3_Greater than recommended stiffness and power setting of a stance-phase powered leg prosthesis can improve step-to-step transition work and effective foot length ratio du... by Joshua R. Tacca (18067213)

“…People with TTA using a stance-phase powered prosthesis (e.g., BiOM, Ottobock, Duderstadt, Germany) walk with increased AL_trail W_pos and potentially decreased magnitude of UL_lead W_neg compared to a passive-elastic prosthesis. …”

DataSheet2_Greater than recommended stiffness and power setting of a stance-phase powered leg prosthesis can improve step-to-step transition work and effective foot length ratio du... by Joshua R. Tacca (18067213)

“…People with TTA using a stance-phase powered prosthesis (e.g., BiOM, Ottobock, Duderstadt, Germany) walk with increased AL_trail W_pos and potentially decreased magnitude of UL_lead W_neg compared to a passive-elastic prosthesis. …”

Trends in faunal bone remains in four coastal middens (A–D) and size changes for <i>Scarus</i> spp. (parrotfish) and <i>Cellana</i> spp. (intertidal limpets) (E) recovered from arc... by John N. Kittinger (203130)

“…<p>Midden remains show decreases in marine fish and increases in domesticated mammals (pigs [<i>Sus scrofa]</i> and dogs [<i>Canis familiaris</i>]) through time, suggesting a change in basic subsistence patterns in Hawaiian prehistory with a decreased reliance on fish versus domesticates. …”

Presentation_1_A Long Non-coding RNA, LOC157273, Is an Effector Transcript at the Chromosome 8p23.1-PPP1R3B Metabolic Traits and Type 2 Diabetes Risk Locus.pdf by Alisa K. Manning (7634102)

“…</p>Results<p>We found that siRNA knockdown decreased LOC157273 transcript levels by approximately 80%, increased PPP1R3B mRNA levels by 1.7-fold, and increased glycogen deposition by >50% in primary human hepatocytes. …”

Table_1_A Long Non-coding RNA, LOC157273, Is an Effector Transcript at the Chromosome 8p23.1-PPP1R3B Metabolic Traits and Type 2 Diabetes Risk Locus.xlsx by Alisa K. Manning (7634102)

“…</p>Results<p>We found that siRNA knockdown decreased LOC157273 transcript levels by approximately 80%, increased PPP1R3B mRNA levels by 1.7-fold, and increased glycogen deposition by >50% in primary human hepatocytes. …”

Data_Sheet_1_Campylobacter Colonization, Environmental Enteric Dysfunction, Stunting, and Associated Risk Factors Among Young Children in Rural Ethiopia: A Cross-Sectional Study Fr... by Dehao Chen (4966207)

“…<p>Livestock farming provides a possible mechanism by which smallholder farmers can meet their household need for animal source foods (ASF), which may reduce the risk of stunting. …”

Schematic illustration depicting the proposed length changes of the contractile element (CE, representing muscle fascicles) and elastic element (EE, representing tendon) of plantar... by Eng Kuan Moo (3830128)

Area under the receiver-operator curve for IVFpredict and Templeton models, and female age alone, for predicting live birth from 130,960 IVF cycles. by Andrew D. A. C. Smith (718811)

“…</p><p>*** Model predicting decreasing probability of live birth with increasing female age categories (18–34, 35–37, 38–39, 40–42, 43–44 and 45–50 years).…”

sNPF/NPY-sNPFR1/NPYR1-PKA-CREB-mnb/Dyrk1a signaling in <i>Drosophila</i> neuronal BG2-c6 cells and mouse hypothalamic GT1-7 cells. by Seung-Hyun Hong (136797)

Data: Median heart rate per minute of motionless dolphins at surface from Towards non-invasive heart rate monitoring in free-ranging cetaceans: a unipolar suction cup tag measured... by Kagari Aoki (9994507)

“…Heart rate then gradually decreased at around 20–50 s and remained relatively constant until the next breath. …”

Essential oil of Pterodon polygalaeflorus Benth attenuates nociception in mice by A.N. Coelho-de-Souza (5837000)

“…The results demonstrated that EOPPgfl presented, at doses approximately 100 times smaller than LD50, an antinociceptive effect that probably was due to anti-inflammatory activities.…”