Identification and Characterization of a Leoligin-Inspired Synthetic Lignan as a TGR5 Agonist by Alexander F. Perhal (20946742)

“…In this study, we identify the natural product-inspired synthetic structural analogue of leoligin, LT-188A (<b>1</b>), as a novel nonsteroidal TGR5 agonist. LT-188A (<b>1</b>) induced cyclic adenosine monophosphate (cAMP) accumulation and cAMP response element (CRE)-dependent luciferase activity in a concentration- and TGR5-dependent manner. …”

Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma by Marzena Mazur (4761027)

“…Rational design, guided by X-ray analysis of several inhibitors bound to human chitotriosidase (hCHIT1), led to the identification of compound <b>7f</b> as a highly potent AMCase inhibitor (IC₅₀ values of 14 and 19 nM against human and mouse enzyme, respectively) and selective (>150× against mCHIT1) with very good PK properties. …”

Three different models explaining the role of <i>sfrp5</i> in hepatic development. by Carsten Stuckenholz (212988)

“…<b>A)</b> Wnt acts as a signaling gradient and any shift in the gradient by increasing or decreasing Sfrp5 levels misaligns the liver bud (asterisk) and pancreatic bud (black arrowhead) with mesodermal signals (red arrows). …”

T₂-weighted MRI (T₂WI) results. by Shigeyoshi Saito (208866)

Flibanserin’s neuroprotective effects are 5-HT_1A receptor-mediated. by Aaron S. Coyner (2889722)

“…(<b>A ii, A iii</b>) Receptor plus thicknesses, with each dot representing average right and left eye thickness from one mouse, demonstrate that both pre-treatment of BALB/c mice with WAY 100635 prior to a flibanserin injection (10 mg/kg WAY + 6 mg/kg Flibanserin, <i>green</i>) and a flibanserin injection in 5-HT_1A knockout mice (5-HT1A KO + 6 mg/kg Flibanserin, <i>red</i>) significantly reduces the observed neuroprotective effects provided by a single 6 mg/kg dose of flibanserin (6 mg/kg Flibanserin, <i>blue</i>) in the <b>(A ii)</b> temporal quadrant and the <b>(A iii)</b> nasal quadrant. …”

Multivariate analysis and CSF Aβ5-40/Aβ1-34. by Niklas Mattsson (144720)

“…<p>Multivariate discriminant analysis of the CSF Aβ pattern for treatment compared with placebo in dogs treated with vehicle (N = 15), NB-C8 (N = 3 at 3 h, N = 3 at 16 h) and NB-B4 (N = 5 at 6 h) (Panels a–b). …”

Comparative gene expression profiling in two congenic mouse strains following infection-5 by Sander Banus (83476)

Kinetic analysis of inorganic phosphate transport in oocytes expressing NPT2a or co-expressing NPT2a and CFTR. by Naziha Bakouh (171145)

“…Data were fitted to the modified Hill equation. Results, as means ± SD, were as follows: the apparent K_m for Na⁺ substrate was 40.7 ± 14.6 in NPT2a-oocytes, not different from 41.8 ± 13.4 mM in NPT2a+CFTR-oocytes; IPi_max was decreased by 39±7% in NPT2a+CFTR-oocytes compared to NPT2a-oocytes (P < 0.05). …”

Representative photographs of colonic claudin-5, claudin-7 and claudin-8 immunostaining in mice. by Xian-Ming Xia (340280)

“…The intensity was significantly decreased in colitis group (B), and increased when treated with AMD3100 (C). …”

FABP5 expression modulates TLR2 and TLR4 mRNA expression. by Fabienne Gally (260470)

“…<b>C.</b> TLR2 mRNA expression was decreased in cells overexpressing FABP5. …”

Galectin-1 inhibits NiV-F₀ endocytosis and maturation. by Omai B. Garner (245658)

“…<p><b>A</b>, Galectin-1 decreases internalization of NiV-F₀ from the plasma membrane. …”

ACh effects on hippocampal neurons confirm its diffusion into V1 deep layers. by Shogo Soma (429657)

“…Topical administration of ACh increased (B) or decreased (C) the number of spikes irrespective of the visual stimulus, suggesting that topically administered ACh reached the CA1 through V1 and white matter. …”

Figure S5. from PADI2-Mediated Citrullination Promotes Prostate Cancer Progression by Lin Wang (11986)

Evidence for extensive anaerobic dechlorination and transformation of the pesticide chlordecone (C₁₀Cl₁₀O) by indigenous microbes in microcosms from Guadeloup... by Line Lomheim (1564468)

“…Observed products included monohydro-, dihydro- and trihydrochlordecone derivatives (C₁₀Cl_10-nO₂H_n; n = 1,2,3), as well as “open cage” C9 polychloroindene compounds (C₉Cl_5-nH_3+n n = 0,1,2) and C10 carboxylated polychloroindene derivatives (C₁₀Cl_4-nO₂H_4+n, n = 0–3). …”

Image_5_CLEC4s as Potential Therapeutic Targets in Hepatocellular Carcinoma Microenvironment.TIF by Yinjiang Zhang (5030006)

“…Also, hsa-miR-4278 and hsa-miR-324-5p, two potential miRNA targets of CLEC4s, were uncovered. …”

Data_Sheet_5_Transcriptional Time Course After Rotator Cuff Tear.XLSX by Laura S. Vasquez-Bolanos (11242737)

Data_Sheet_5_Transcriptional Time Course After Rotator Cuff Tear.XLSX by Laura S. Vasquez-Bolanos (11242737)

Position and length of uORFs in the 5´UTR of transcripts subject to Tm-controlled translation. by Nahuel A. Paolini (5081699)

Limited PNGase F digestion of GP5–HA to show modification with three glycans. by Bastian Thaa (418825)

“…The number of carbohydrates cleaved by PNGase F decreases with decreasing concentration. This causes a ladder-like appearance of bands that allows counting of the total number of carbohydrates linked to GP5–HA (arrowheads). …”

Immunoblotting for CRMP1, DPYSL5, NDRG1, FSCN1 and PRDX6. by Lu Qin (124431)

“…<p>Quantification of protein levels showed increased expression of CRMP1 (A), DPYSL5 (B), NDRG1 (C) and FSCN1 (D) and decreased expression of PRDX6 (E) in brain tissue of childhood cortical dysplasia patients compared to controls. …”