Supplementary Material for: Effect of Renin-Angiotensin System Blockers in Acute Myocardial Infarction Patients with Acute Kidney Injury by Kim K.A. (3823120)

“…Methods: Patients from a multicenter AMI registry undergoing percutaneous coronary intervention in Korea were stratified and analyzed according to the presence of AKI, defined as an increase in serum creatinine levels of ≥ 0.3mg/dL or ≥ 50% increase from baseline during admission, and RASB prescription at discharge. …”

Projections of the impact of Combination I intervention on HIV incidence. by Ramzi A. Alsallaq (276295)

“…Incidence reductions of more than 50% (IRR<0.5) are delineated and the star marks IRR value with risk behaviour change assumptions as in (A) and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0054575#pone-0054575-t002" target="_blank">Table 2</a>, (<b>C</b>) Projections of percentage reduction in incidence of the Combination I intervention with respect to current standard incidence projection of 2.1 (1.9–2.3) per 100 pyar at year 15 with various assumptions of failure to achieve the uptake levels of the interventions in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0054575#pone-0054575-t002" target="_blank">Table 2:</a> (Ia) decreasing testing uptake to 60% in community testing rounds, (Ib) doubling the drop out rate on treatment to 28% per year, (Ic) halving the uptake of circumcision to 35% of uncircumcised men, and (Id) assuming no risk behaviour change following HIV diagnosis generated by testing.…”

Table7_Preeclamptic programming unevenly perturbs inflammatory and renal vasodilatory outcomes of endotoxemia in rat offspring: modulation by losartan and pioglitazone.XLSX by Hagar A. Morgaan (15350347)

“…</p><p>Methods: PE was induced by oral administration of L-NAME (50 mg/kg/day) for the last 7 days of pregnancy. …”

Table1_Preeclamptic programming unevenly perturbs inflammatory and renal vasodilatory outcomes of endotoxemia in rat offspring: modulation by losartan and pioglitazone.XLSX by Hagar A. Morgaan (15350347)

“…</p><p>Methods: PE was induced by oral administration of L-NAME (50 mg/kg/day) for the last 7 days of pregnancy. …”

Sorting of VAMPs 4 and 7. by Daniela A. Sahlender (201771)

“…<p>a, Schematic diagrams of the wild-type and mutant constructs. b, Alignment of the SNARE domains of the five VAMPs. …”

Table5_Preeclamptic programming unevenly perturbs inflammatory and renal vasodilatory outcomes of endotoxemia in rat offspring: modulation by losartan and pioglitazone.XLSX by Hagar A. Morgaan (15350347)

“…</p><p>Methods: PE was induced by oral administration of L-NAME (50 mg/kg/day) for the last 7 days of pregnancy. …”

Image2_First-in-Human, Double-Blind, Randomized, Placebo-Controlled Trial of TQ-F3083, a New Dipeptidyl Peptidase-4 Inhibitor, in Healthy Chinese Adults.TIF by Jingrui Liu (1694983)

“…The accumulation factor was 1.39 after multiple dose for 7 days. Decreased plasma exposure (84.87% decrease in C_max, 49.23% in AUC_0-t, and 47.77% in AUC_0-∞) was observed with administration after a high-fat and high-calorie standardized breakfast. …”

Image1_First-in-Human, Double-Blind, Randomized, Placebo-Controlled Trial of TQ-F3083, a New Dipeptidyl Peptidase-4 Inhibitor, in Healthy Chinese Adults.TIF by Jingrui Liu (1694983)

“…The accumulation factor was 1.39 after multiple dose for 7 days. Decreased plasma exposure (84.87% decrease in C_max, 49.23% in AUC_0-t, and 47.77% in AUC_0-∞) was observed with administration after a high-fat and high-calorie standardized breakfast. …”

Table 2_Global, regional, and national burden of intracerebral hemorrhage and attributable risk factors in youths and young adults, 1990–2021: a statistical analysis of incidence,... by Bing Wu (172312)

“…The incidence rate declined from 11.31 (95% UI, 8.56, 14.27) per 100,000 individuals in 1990 to 8.30 (95% UI, 6.46, 10.19) per 100,000 individuals in 2021, an overall decrease of −26.62% (95% UI, −30.85 to −22.24). Among the five Sociodemographic Index (SDI) regions, the highest EAPCs were observed in the high SDI regions for incidence (−1.63%; 95% CI, −1.74 to −1.52), mortality (−1.79%; 95% CI, −2.01 to −1.58), and DALYs (−1.67%; 95% UI, −1.84 to −1.50). …”

Image3_First-in-Human, Double-Blind, Randomized, Placebo-Controlled Trial of TQ-F3083, a New Dipeptidyl Peptidase-4 Inhibitor, in Healthy Chinese Adults.TIF by Jingrui Liu (1694983)

“…The accumulation factor was 1.39 after multiple dose for 7 days. Decreased plasma exposure (84.87% decrease in C_max, 49.23% in AUC_0-t, and 47.77% in AUC_0-∞) was observed with administration after a high-fat and high-calorie standardized breakfast. …”

Table 1_Global, regional, and national burden of intracerebral hemorrhage and attributable risk factors in youths and young adults, 1990–2021: a statistical analysis of incidence,... by Bing Wu (172312)

“…The incidence rate declined from 11.31 (95% UI, 8.56, 14.27) per 100,000 individuals in 1990 to 8.30 (95% UI, 6.46, 10.19) per 100,000 individuals in 2021, an overall decrease of −26.62% (95% UI, −30.85 to −22.24). Among the five Sociodemographic Index (SDI) regions, the highest EAPCs were observed in the high SDI regions for incidence (−1.63%; 95% CI, −1.74 to −1.52), mortality (−1.79%; 95% CI, −2.01 to −1.58), and DALYs (−1.67%; 95% UI, −1.84 to −1.50). …”

Transmission of reduced levels of miR-34/449 from sperm to preimplantation embryos is a key step in the transgenerational epigenetic inheritance of the effects of paternal chronic... by Alexandre Champroux (18547075)

“…Thus, suppression of this miRNA amplification system when sperm miR-34c levels are reduced in CSI stressed mice can explain how a comparable fold-suppression of miR-34/449 levels can be found in PIEs derived from them, despite sperm containing ~50-fold lower levels of these miRNAs than those already present in PIEs. …”

Inhibition of collagen and fibronectin expression by roscovitine in SSc and in normal fibroblasts. by Richard A. Steinman (117481)

“…Cells treated for 23 hours with DMSO vehicle (D), 6.25 µg/mL roscovitine (R), 10 ng/mL TGF-β (T), or 50 ng/mL IL-6 (6). PARP band at 116 kD is also shown; no 89 kD cleaved PARP band (a marker of apoptosis) was detected. …”

Image1_Development, Optimization and Evaluation of 2-Methoxy-Estradiol Loaded Nanocarrier for Prostate Cancer.pdf by Nabil A. Alhakamy (1963378)

“…<p>The therapeutic efficacy of antineoplastic agents possessing a selective target to the nucleus of the cancer cells could be enhanced through novel formulation approaches. …”

miR-223 null macrophages have enhanced inflammatory signaling and increased FBXW7 levels. by Jeffrey A. Deiuliis (3331071)

“…(C) Immunoblot data examining response of primary macrophages from WT and miR-223 knockout mice (KO) to LPS and combined IFNγ/LPS; 50μg of whole cell lysate was loaded per lane and run on a denaturing SDS PAGE gel. …”

AdV-ZFP-VEGF significantly reduces mechanical and thermal allodynia at 8 weeks post-SCI. by Sarah A. Figley (389639)

“…(C) Below-level thermal allodynia. A 50°C thermal stimulus was applied to the distal tip of the tail. …”

Table1_CHF6297: a novel potent and selective p38 MAPK inhibitor with robust anti-inflammatory activity and suitable for inhaled pulmonary administration as dry powder.DOCX by Cataldo Martucci (3117069)

“…Here, we report the in vitro and in vivo characterization of the anti-inflammatory effects of CHF6297, a novel potent and selective p38α inhibitor designed for inhalation delivery as a dry powder formulation. …”

Table1_CHF6297: a novel potent and selective p38 MAPK inhibitor with robust anti-inflammatory activity and suitable for inhaled pulmonary administration as dry powder.DOCX by Cataldo Martucci (3117069)

“…Here, we report the in vitro and in vivo characterization of the anti-inflammatory effects of CHF6297, a novel potent and selective p38α inhibitor designed for inhalation delivery as a dry powder formulation. …”

DataSheet1_A Novel System for Evaluating the Inhibition Effect of Drugs on Cytochrome P450 Enzymes in vitro Based on Human-Induced Hepatocytes (hiHeps).DOCX by Yan Li (23143)

“…The aim was to establish a novel evaluation system for the effect of drugs on CYP3A4, 1A2, 2B6, 2C9, and 2C19 in vitro based on hiHeps. …”

Low numbers of proliferating cells are observed in response to cerebral hypoperfusion however a proportion of newly generated cells differentiate into mature oligodendrocytes withi... by Jamie McQueen (518886)

“…<p>(A) Representative confocal images showing PCNA labelling of proliferating cells in the corpus callosum. …”