Discovery of β‑Arrestin Biased Ligands of 5‑HT₇R by Youngjae Kim (1463614)

“…Though many studies have been published about therapeutic potentials of selective 5-HT₇R ligands, there have been few biased ligands of 5-HT₇R. …”

Discovery of β‑Arrestin Biased Ligands of 5‑HT₇R by Youngjae Kim (1463614)

“…Though many studies have been published about therapeutic potentials of selective 5-HT₇R ligands, there have been few biased ligands of 5-HT₇R. …”

Filamentation induced by DTPA is associated with a decrease in Nrg1 protein level, and requires the cAMP-PKA pathway and the kinase Sok1. by Elizabeth J. Polvi (3163500)

Flibanserin’s neuroprotective effects are 5-HT_1A receptor-mediated. by Aaron S. Coyner (2889722)

“…A 6 mg/kg dose of flibanserin in 5-HT_1A knockout mice (5-HT1A KO + 6 mg/kg Flibanserin, <i>red</i>) resulted in average receptor plus thickness that was not significantly different from vehicle-injected and naïve mice. …”

Stress responses after knockdown of octopamine receptor OAMB and serotonin receptor 5-HT_1A in IPCs. by Jiangnan Luo (218899)

“…In an earlier study it was shown that 5-HT_1A knockdown decreased starvation resistance <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0099732#pone.0099732-Luo1" target="_blank">[22]</a>. …”

a-f. PSP significantly decreased NP-specific IgM responses at days 4 and 21 compared to ACACIA. by Bhagwant Kaur Sekhon (847697)

Decrease in capillary oxygen saturation of hemoglobin (SO_2capillary) at rest and after incremental test in different conditions. by Zofia Piotrowicz (7534901)

Anti-CXCR3 group decreased number of specific CD8⁺ T cells as well as polyfunctionality after infection with <i>T</i>. <i>cruzi</i>. by Camila Pontes Ferreira (6194006)

Tg2576 mice treated with OG showed markedly increased α-secretase cleavage of APP and significantly decreased levels of Aβ generation. by She-Qing Zhang (446556)

Effect of Safr and Cands on the levels of complex I (U/mg protein), complex II (U/mg protein), complex IV (U/mg protein), caspase-3 (Casp-3, μg/mg protein), Fas ligand (FasL, μg/mg... by Nagwa Ibrahim Shehata (17319689)

Subjects:

IL-18 induces death in HT-29 cells. by Ossama Allam (5043434)

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

The effects of TDBP-TAZTO (5 and 50 mg/kg) on spatial learning and memory in rats in the Morris water test. by Liang Ye (6646)

“…Data ate expressed as mean ± SE (n = 10/group). ^a<i>p</i> < 0.05, TDBP-TAZTO 5 mg/kg group vs. control group; ^b<i>p</i> < 0.05, TDBP-TAZTO 50 mg/kg group vs. control group.…”

Temporal profiles of the key BO-NN features. by Julia Berezutskaya (9080269)

“…Right plot show the gradual decrease in the TM tuning for the features highlighted in <b>c</b> as well as the gradual increase in the temporal response profile (i.e. optimal shifts for the prediction of the key BO-NN features using Praat features shown in <b>a</b>). …”

Lovastatin treatment decreases ICAM-1 and CD11b expression and vascular permeability and induce HMOX-1 expression in the brains of mice with CM. by Patricia A. Reis (109310)

Effectiveness of E cytotoxicity presented as a half maximal growth inhibitory concentration (CC₅₀). by Anna Kalota (7415)

Anatomical confirmation of drug injection sites. by Diana Amorim (662998)

Inhibition of G9a decreases the tumorigenicity of neuroblastoma cells. by Xiao-Xue Ke (626989)

The Anion [Mg₆Cl₈Cp*₅]^-:  A Final Intermediate on the Way to the Molecular Donor-Free Grignard Compound MgClCp*? by Jean Vollet (2644651)

“…At a slightly higher temperature and by stepwise decrease of the diethyl ether concentration before reaction, a preferred formation of metal clusters such as dodekakispentamethylcyclopentadienylpentaconta-aluminum, Al₅₀Cp*₁₂, was frequently observed. …”