Pharmacokinetic models and concentrations predictions of treatments considered. حسب Guillaume Lingas (9955528)

الموضوعات:

Mutagenesis model simulations. حسب Guillaume Lingas (9955528)

الموضوعات:

Human cerebral organoids treated with VPA show a decreased size, impaired neurogenesis, and induction of senescence in NE cells. حسب Muriel Rhinn (406515)

Oral administration of TVSE decreases angiogenesis in 4T1 tumors in BALB/c mice. حسب Hyun Sook Lee (8039876)

Deep crypt secretory (DCS) cells are predominantly distributed in the proximal colon, with a progressive decrease towards the distal colon. حسب Daisuke Sugahara (2047696)

Growth of cell monolayers and 3D spheroids under different concentrations of HIF inhibitor YC-1 in growth media. حسب Sreerupa Sarkar (9628788)

EGFR/ERK signaling activity decreases throughout LEC elimination with endocytic activity dependency. حسب Kevin Yuswan (19845885)

Decrease of the DXR-induced genotoxicity and nongenotoxic effects of Theobroma cacao revealed by micronucleus assay حسب M. F. G. Boriollo (4894975)

Exposure to low CO₂ levels decreases ER cholesterol levels. حسب Nityanand Bolshette (17396845)

"…<b>(C)</b> Total cholesterol quantification (with fluorometric assay kit) in NIH3T3 cells depleted with sterols for 2 h or exposed to different CO₂ levels for 4 h (mean ± SE, <i>n</i> = 3 biological replicates per condition, **<i>P</i> < 0.01, nonsignificant (ns), two-sided Student’s <i>t</i> test). <b>(D, E)</b> The free cholesterol and cholesterol ester levels in the ER membrane from the cells as in <b>(C)</b>, were quantified with shotgun lipidomics analysis (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s007" target="_blank">S7 Fig</a> and <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s012" target="_blank">S5 Table</a>) (mean ± SE, <i>n</i> = 3 independent experiments, **<i>P</i> < 0.01, *<i>P</i> < 0.05, nonsignificant (ns) two-sided Student’s <i>t</i> test). …"

Treatment with TDF decreased cell viability and induced morphological changes in hepatic stellate cells. حسب Sung Won Lee (222509)

VEEV CPD shows decreased phosphorylation of capsid and replication is not sensitive to loss of PKCδ. حسب Brian D. Carey (6092747)

Conditional ablation of <i>Ybx1</i> leads to a reduction in cortical progenitor cell pool and a decrease in cortical thickness. حسب Jian Zhang (1682)

The second-order rate-yield tradeoff demonstrated by decreasing the P/O ratio and and knocking out <i>gnd</i> (“Δ<i>gnd</i>”) in ME-model simulations. حسب Chuankai Cheng (6791417)

Thermal denaturation of ZIKV NS2B/NS3^pro and CHIKV nsP2^pro using fluorescence spectroscopy. حسب Raphael J. Eberle (9286932)

Ectopic development of a small number of adipocytes, as well as mitochondrial morphology and dynamics, in thymus from cocaine-administered rats. حسب Kana Unuma (283272)

الموضوعات:

JBPOS0101 decreased Amyloid Beta (Aβ) aggregates in the cortex and hippocampal regions in 5xFAD mouse brains. حسب Jihoon Jeong (4852690)

Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant حسب Ittipat Meewan (7455041)

"…Hepatitis C virus (HCV) is a human pathogen with high morbidity. The HCV NS3/4A protease is essential for viral replication and is one of the top three drug targets. …"

EVs obtained from U937 cells increased the expression of adhesion molecules in endothelial cells EA.hy926. حسب Myriam Lucia Velandia-Romero (8259726)

"…Cells infected with DENV-2 at MOI 0.2 (IC) showed a slight decrease in the expression of VE-Cad, while in cells exposed to <i>P (+ or -)</i> or <i>EV (+ 4G2 or UV)</i> showed a bright fluorescence pattern that delimits the cells. …"

Variable importance plot (mean decrease accuracy and mean decrease Gini). حسب Fernando Martinez-Taboada (8655132)

NS affects lipid transport in ApoE^-/-mouse models. حسب Yihua Wang (491766)