Schematic representation of the effects of stepwise bromination of the benzene ring of benzotriazole (Bt), including interdependence of the molecular volume (A) and pK_a (B) of the products with their IC₅₀ for inhibition of protein kinase CK2α: (a) Green arrows follow sequential bromination of the central vicinal C(5)/C(6) atoms, leading to a moderate decrease of pK_a and a large decrease in IC₅₀; (b) Red arrows illustrate the lesser effects of bromination of the peripheral C(4)/C(7) atoms, resulting in a significant decrease of pK_a, with virtually no gain in inhibitory activity; (c) Black lines link products with the same number of bromine atoms, but substantially differing in pK_a and IC₅₀, culminating in the di- and tri-brominated derivatives with inhibitory activities comparable to that of TBBt. by Romualda Wąsik (119538)

Phosphorylation as an Effective Tool to Improve Stability and Reduce Toxicity of Antimicrobial Peptides by Zufang Ba (11036420)

“…Phosphorylation can reduce toxicity and improve the stability of AMPs. Based on these, we designed a series of peptides and their corresponding phosphorylated forms. …”

Simultaneous silencing of isoamylases ISA1, ISA2 and ISA3 by multi-target RNAi in potato tubers leads to decreased starch content and an early sprouting phenotype by Stephanus J. Ferreira (4249219)

Imatinib induces the differentiation of human normal erythroblasts and decreases cell surface expression of c-Kit. by Diane D'allard (405441)

ST2-104 decreases the Aβ_25-35-mediated increase in intracellular Ca²⁺. by Yingshi Ji (9013004)

PLD1 inhibition decreases the c-Myc-dependent dNTP biosynthetic transcriptional program. by Harry E. Taylor (596259)

KL perception mutants exhibit decreased epidermal cell lengths and root diameter. by José Antonio Villaécija-Aguilar (7326242)

Cldn6 suppression and C-CPE exposure decrease HNF4α-induced epithelial morphogenesis. by Kotaro Sugimoto (467914)

hMSC adjunctive therapy failed to decrease pulmonary inflammation or prevent ALI compared to antiviral therapy alone in experimental severe influenza. by Ilyse Darwish (446378)

“…<p>Eight-week old male C57Bl/6 mice infected with 425 EID₅₀ influenza A/PR/8 virus were administered 2.5 mg/kg oseltamivir in 100 ul ddH2O via gavage, 1×daily for 5 days, beginning day 2 P.I., with or without hMSC administration (5×10⁵ cells) on day 2 P.I. and sacrificed on day 7 P.I. …”

Netrin-1 overexpression increases HCV RNA and specific infectivity of HCV virions in vitro whereas Netrin-1 depletion decreases HCV RNA and specific infectivity in vitro. by Marie-Laure Plissonnier (337713)

“…<b>C.</b> Supernatant infectivity was quantified on days two and four post-infection by the TCID₅₀ method (<i>n</i> = 3, Mann-Whitney test, <i>p</i> < 0.05.). …”

Blocking CD4, integrins, and lectins simultaneously significantly decreased DC binding and uptake of both free and complement opsonized HIV-1. by Veronica Tjomsland (210021)

Minimum quorum sensing inhibitory concentrations (MQSICs), minimum inhibitory concentrations (MICs), and concentrations inhibiting 50% of violacein production (IC50s) of compounds... by Jean Paul Dzoyem (6424445)

Subjects:

Data from: Spillage and food dust do not decrease efficacy of long-lasting insecticide-incorporated netting against stored product insects by Sabita Ranabhat (17484660)

The transmission decreases as the distance or PM_2.5 index increases. by Chenbin Liu (1405879)

GFRα2 expression was dramatically decreased in Runx1 knockout mice. by Ting Wang (16292)

“…<p>ISH for GFRα2 in WT (<b><i>A</i></b>) and Runx1 knock out (<b><i>A^/</i></b>) mouse DRG showed significant reduction of GFRα2 in Runx1^−/− ganglia. …”

VASH1 controls SOD2 level and decreases ROS level in HUVECs. by Hiroki Miyashita (131087)

Inhibition of ATR activation significantly decreases B19V-induced G2 arrest in infected CD36⁺ EPCs. by Peng Xu (17962)

Fig 2 - by Nida Mansoora (11648641)

Subjects:

Exposure to IQ3A compounds decreases <i>HSP90</i> and <i>KRAS</i> mRNA, protein expression and <i>KRAS</i> transcription. by Hugo Brito (747224)

Decreased oxidative stress in the heart tissue with HMGB1 fragment. by Takashi Kido (409970)