Showing 61 - 80 results of 44,119 for search '(( 50 ((((mg decrease) OR (we decrease))) OR (nn decrease)) ) OR ( 2 c decrease ))', query time: 0.76s Refine Results
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    Fig 2 - by Nida Mansoora (11648641)

    Published 2021
    Subjects:
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    Fig 2 - by Ernesto Canalis (516050)

    Published 2022
    Subjects:
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    Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben... by Shuhei Ikeda (2380180)

    Published 2021
    “…Optimization of the left hand side afforded <b>4f</b> as a promising reversible MAGL inhibitor, which showed potent in vitro MAGL inhibitory activity (IC<sub>50</sub> 6.2 nM), good oral absorption, blood–brain barrier penetration, and significant pharmacodynamic changes (2-arachidonoylglycerol increase and arachidonic acid decrease) at 0.3–10 mg/kg, po. in mice.…”
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    S2 File - by Xiaoqing Li (186909)

    Published 2024
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