An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing by Raymond W. Wong (8463498)

“…<div><p>The ability of HIV-1 to evolve resistance to combined antiretroviral therapies (cARTs) has stimulated research into alternative means of controlling this infection. We assayed >60 modulators of RNA alternative splicing (AS) to identify new inhibitors of HIV-1 RNA processing—a segment of the viral lifecycle not targeted by current drugs—and discovered compound N-[4-chloro-3-(trifluoromethyl)phenyl]-7-nitro-2,1,3-benzoxadiazol-4-amine (5342191) as a potent inhibitor of both wild-type (<i>Ba-L</i>, <i>NL4-3</i>, <i>LAI</i>, <i>IIIB</i>, and <i>N54</i>) and drug-resistant strains of HIV-1 (IC₅₀: ~700 nM) with no significant effect on cell viability at doses tested. 5342191 blocks expression of four essential HIV-1 structural and regulatory proteins (Gag, Env, Tat, and Rev) without affecting total protein synthesis of the cell. …”

Image_1_Weaning Age Affects the Development of the Ruminal Bacterial and Archaeal Community in Hu Lambs During Early Life.JPEG by Huiling Mao (6520772)

“…Compared to W30, PW30 had a decreased relative abundance of Bacteroidetes. …”

Table_1_Weaning Age Affects the Development of the Ruminal Bacterial and Archaeal Community in Hu Lambs During Early Life.DOCX by Huiling Mao (6520772)

“…Compared to W30, PW30 had a decreased relative abundance of Bacteroidetes. …”

TNNI3K expression leads to premature death in the <i>Csq</i> transgenic model of cardiomyopathy. by Ferrin C. Wheeler (259443)

“…Survival is severely decreased for double positive transgenics (<i>TNNI3K^tg</i>/<i>Csq^tg</i>) to an average of 17 days with a range from 15 to 21 days. …”

Future Mangrove Carbon Storage Under Climate Change and Deforestation by Chatting, Mark

“…Projecting current mangrove deforestation rates into the future resulted in a total of 678.50 ± 151.32 Tg CO2e emitted from 2012 to 2095. …”
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Pollen-based Holocene vegetation reconstruction.xlsx by Yuanhao Sun (12697028)

“…In the Daihai basin, the vegetation cover changed relatively little, maintaining values of 45–50%, and only increased during the interval of 8–5.1 ka, when it attained a maximum of 67%. …”

Table1_Anti-hyperglycemic effects of Cissus quadrangularis extract via regulation of gluconeogenesis in type 2 diabetic db/db mice.DOCX by Jeong-Won Kim (18464976)

“…In this study, the therapeutic effects of C. quadrangularis extract (CQR-300) on type 2 diabetes mellitus (T2DM) were investigated in a leptin receptor-mutated db/db mouse model.</p><p>Methods: CQR-300 was orally administered to db/db mice (n = 6/group) at different doses (50, 100, and 200 mg/kg) for 8 weeks. …”

Datasheet1_Diagnostic and prognostic value of an ejection fraction adjusted for myocardial remodeling.docx by Wei Xuan Chan (11949866)

“…Both low EF and low EFa were associated with a high HF readmission risk. However, in the cohort with a normal EF (EF ≥ 50%), models using EFa were significantly more associative with HF readmissions within 3 years, where the leave one out cross validation ROC analysis showed a 18.6% reduction in errors, and Net Classification Index (NRI) analysis showed that risk increment classification of events increased by 12.2%, while risk decrement classification of non-events decreased by 16.6%.…”

Supplementary Material for: Postoperative Acute Kidney Injury: Focus on Renal Recovery Definitions, Kidney Disease Progression and Survival by Long T.E. (6276614)

“…Risk of incident and progressive CKD within 5 years was significantly increased if patients did not achieve a reduction in SCr to < 1.5 × baseline (hazard ratio [HR] 1.50; 95% CI 1.29–1.75) and if renal recovery was limited to a fall in SCr to 1.25–1.5 × baseline (HR 1.32; 95% CI 1.12–1.57) within 30 days. …”

Conditional knockout and genotyping strategies. by Ping Xu (122619)

“…(D) As determined by qPCR, <i>Rfx4</i> mRNA levels were decreased by approximately 50% (P< 0.01, n = 4) in the brains of <i>Rfx4</i><b><i>^+/-</i></b> mice, as determined by fold changes after normalizing with <i>Gapdh</i> mRNA. …”

pH sensitive lipid polymeric hybrid nanoparticle (LPHNP) of paclitaxel and curcumin for targeted delivery in breast cancer by Hrishikesh Sarma (14827761)

“…MTT-assay studies revealed enhanced cytotoxicity of CUR and PTX as LPHNPs showing IC₅₀ value of free CUR & PTX 480.06 µg/mL decreasing to 282.97 µg/mL for CS-CUR-PTX-LPHNPs. …”

Table_1_Reassessing Particulate Organic Carbon Dynamics in the Highly Disturbed San Francisco Bay Estuary.XLSX by Peter J. Hernes (8640351)

“…Lignin compositional data (syringyl:vanillyl and cinnamyl:vanillyl) suggest that increased lignin content in the more saline samples could be derived from wetland materials, while a two-endmember mixing model indicates that a significant portion of the particulate organic carbon (POC) in the western sites (50–60% as an upper bound, 13–15% as a lower bound) could be wetland-derived. …”

Table_2_Reassessing Particulate Organic Carbon Dynamics in the Highly Disturbed San Francisco Bay Estuary.XLSX by Peter J. Hernes (8640351)

“…Lignin compositional data (syringyl:vanillyl and cinnamyl:vanillyl) suggest that increased lignin content in the more saline samples could be derived from wetland materials, while a two-endmember mixing model indicates that a significant portion of the particulate organic carbon (POC) in the western sites (50–60% as an upper bound, 13–15% as a lower bound) could be wetland-derived. …”

Gene expression profiles in wildtype, <i>Tnfr1</i>- and <i>Tnfr2-</i>deficient glomeruli after TNF stimulation ex vivo. by Anela Taubitz (433585)

“…<p>Expression profiling by microarrays was performed on isolated glomeruli from wildtype, <i>Tnfr1</i>−/− and <i>Tnfr2</i>−/− mice 12 after stimulation with 50 ng/ml TNF for 12 hours ex vivo. A negativ “fold change” (black to green) indicates decreased expression and a postive “fold change” (black to red) indicates increased expression in a glomerular sample compared with the average of all analyzed samples. …”

Datasheet1_Diagnostic and prognostic value of an ejection fraction adjusted for myocardial remodeling.docx by Wei Xuan Chan (11949866)

“…Both low EF and low EFa were associated with a high HF readmission risk. However, in the cohort with a normal EF (EF ≥ 50%), models using EFa were significantly more associative with HF readmissions within 3 years, where the leave one out cross validation ROC analysis showed a 18.6% reduction in errors, and Net Classification Index (NRI) analysis showed that risk increment classification of events increased by 12.2%, while risk decrement classification of non-events decreased by 16.6%.…”

Image1_Anti-hyperglycemic effects of Cissus quadrangularis extract via regulation of gluconeogenesis in type 2 diabetic db/db mice.TIF by Jeong-Won Kim (18464976)

“…In this study, the therapeutic effects of C. quadrangularis extract (CQR-300) on type 2 diabetes mellitus (T2DM) were investigated in a leptin receptor-mutated db/db mouse model.</p><p>Methods: CQR-300 was orally administered to db/db mice (n = 6/group) at different doses (50, 100, and 200 mg/kg) for 8 weeks. …”

Presentation1_Anti-hyperglycemic effects of Cissus quadrangularis extract via regulation of gluconeogenesis in type 2 diabetic db/db mice.PPTX by Jeong-Won Kim (18464976)

“…In this study, the therapeutic effects of C. quadrangularis extract (CQR-300) on type 2 diabetes mellitus (T2DM) were investigated in a leptin receptor-mutated db/db mouse model.</p><p>Methods: CQR-300 was orally administered to db/db mice (n = 6/group) at different doses (50, 100, and 200 mg/kg) for 8 weeks. …”

Image2_Anti-hyperglycemic effects of Cissus quadrangularis extract via regulation of gluconeogenesis in type 2 diabetic db/db mice.TIF by Jeong-Won Kim (18464976)

“…In this study, the therapeutic effects of C. quadrangularis extract (CQR-300) on type 2 diabetes mellitus (T2DM) were investigated in a leptin receptor-mutated db/db mouse model.</p><p>Methods: CQR-300 was orally administered to db/db mice (n = 6/group) at different doses (50, 100, and 200 mg/kg) for 8 weeks. …”

Data_Sheet_1_Differentiated Mechanisms of Biochar Mitigating Straw-Induced Greenhouse Gas Emissions in Two Contrasting Paddy Soils.docx by Ya-Qi Wang (585856)

“…Results showed that straw addition markedly increased the cumulative CH₄ emissions in both soils by 4.7- to 9.1-fold and 23.8- to 72.4-fold at low (S1) and high (S2) straw input rate, respectively, and significantly increased mcrA gene abundance. Biochar amendment under the high straw input (BS2) significantly decreased CH₄ emissions by more than 50% in both soils, and increased both mcrA gene and pmoA gene abundances, with greatly enhanced pmoA gene and a decreased mcrA/pmoA gene ratio. …”

Frequency-dependent activation in NF trabeculae (<i>n</i> = 9) vs. failing trabeculae with no hypothyroidism (FNH; <i>n</i> = 9) and failing trabeculae with hypothyroidism (FH; <i>... by Nancy S. Saad (2615341)

“…<b>(D)</b> TTP shortened upon increasing frequency of stimulation in all groups with no differences between NF and both failing groups at each respective frequency. <b>(E)</b> RT50 decreased as frequency increased from 0.5 Hz to 3 Hz in all three groups. …”