Image_4_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_1_Combined Effect of CYP2C19 Genetic Polymorphisms and C-Reactive Protein on Voriconazole Exposure and Dosing in Immunocompromised Children.JPEG by Juan Chen (61123)

“…Covariates associated with voriconazole plasma concentrations and dose requirements were adjusted by using generalized linear mixed-effect models.</p>Results<p>A total of 682 voriconazole steady-state trough concentrations from 91 Chinese pediatric patients were included. …”

Mobility Competitiveness and Security: Expatriate Perspectives from Qatar by Ewers, Michael Christopher

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Length-dependent activation in NF trabeculae (<i>n</i> = 9) vs. failing trabeculae with no hypothyroidism (FNH; <i>n</i> = 9) and failing trabeculae with hypothyroidism (FH; <i>n</... by Nancy S. Saad (2615341)

“…<b>(E)</b> RT50 decreased as muscles were shortened from L₁₀₀ to L₈₅ and the degree of shortening was much obvious in NF group. …”

Sound evoked cortical activity across vigilance states before and after NOE. by Linus Milinski (10532121)

“…Sounds were one octave narrow band noise (NBN) bursts centred at 1, 4, 8, and 16 kHz, at a stimulus level of 40, 50, 60, and 65 dB SPL, with a duration of 820 ms that included a silent gap of 38 ms. …”

Image_1_Fcγ Receptor IIB Controls Skin Inflammation in an Active Model of Epidermolysis Bullosa Acquisita.TIF by Balint Kovacs (8294496)

“…In contrast to the antibody-transfer-induced EBA model, individual targeting of FcγRIII or FcγRIV decreased ROS release to 50%. Combined FcγR blocking abrogated ROS release from BM neutrophils. …”

DataSheet1_Mechanism of Tripterygium wilfordii Hook.F.- Trichosanthes kirilowii Maxim decoction in treatment of diabetic kidney disease based on network pharmacology and molecular... by Lingfei Lu (5400374)

“…Molecular docking results showed that kaempferol, triptolide, nobiletin, and schottenol had a strong binding ability to PTGS2 and RELA. Furthermore, the in vitro experiments confirmed that LTD effectively decreased the expression of PTGS2, NF-κB, JNK, and AKT in the HG-induced DKD model.…”

Data_Sheet_1_Functional Exhaustion of Type I and II Interferons Production in Severe COVID-19 Patients.docx by Caroline Ruetsch (9691565)

“…In vitro treatment with type IFNα restored type IFNγ secretion in COVID-19 patients while the secretion of pro-inflammatory cytokines IL6 and IL1β remained stable or decreased, respectively. These results (a) demonstrate a functional exhaustion of both innate and adaptive immune response in severe forms of COVID-19; (b) identify IFNα and IFNγ as new potential biomarkers of severity; and (c) highlight the importance of targeting IFNs when considering COVID-19 treatment in order to re-establish a normal balance between inflammatory and Th1 effector cytokines.…”

Concomitant nevirapine impacts pharmacokinetic exposure to the antimalarial artemether-lumefantrine in African children by Liusheng Huang (610226)

“…Similarly, peak concentration was decreased by 50% (p = 0.07) for artemether and 36% (p = 0.01) for dihydroartemisinin. …”

Proxy-based paleoclimate series for the last 5000 years. by David Kaniewski (218243)

“…Interval of high (low) Cyperaceae pollen percentages are interpreted in terms of increased (decreased) Nile flow; (<b>g</b>) fluctuations of the δ¹⁸O speleothem scores from Soreq Cave, Israel, for the last 3600 years <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071004#pone.0071004-BarMatthews1" target="_blank">[70]</a>. …”

Table 1_Multicenter epidemiology of Stenotrophomonas maltophilia bloodstream infections in Indian ICUs: building digital surveillance network.pdf by Parul Singh (191877)

“…Mortality was highest in secondary BSIs (60%), followed by CLABSIs (50.3%) and non-CLABSIs (36.4%). The median ICU stay for CLABSI patients was 21 days. …”

5′pppRNA activates innate immunity and protects mice from lethal influenza infection <i>in vivo</i>. by Marie-Line Goulet (407117)

“…Percent survival (<b>A</b>) and percent weight loss (<b>B</b>) were monitored. …”

Image_2_Multiomic Fermentation Using Chemically Defined Synthetic Hydrolyzates Revealed Multiple Effects of Lignocellulose-Derived Inhibitors on Cell Physiology and Xylose Utilizat... by Yaoping Zhang (629825)

“…<p>Utilization of both C5 and C6 sugars to produce biofuels and bioproducts is a key goal for the development of integrated lignocellulosic biorefineries. …”

Table_1_In vitro Cytotoxicity and Pharmacokinetic Evaluation of Pharmacological Ascorbate in Dogs.DOCX by Margaret L. Musser (7829228)

Image_2_Automated contouring, treatment planning, and quality assurance for VMAT craniospinal irradiation (VMAT-CSI).png by Eric Simiele (18336738)

“…Purpose<p>Create a comprehensive automated solution for pediatric and adult VMAT-CSI including contouring, planning, and plan check to reduce planning time and improve plan quality.…”

Reduced claudin-1 expression enhances suspended cells and impairs LPA-mediated Boyden chamber migration using SKOV-3 ovarian cancer cells. by Mandi M. Murph (263899)

“…Claudin-1 expression was consistently decreased >50%. (B) Quantitative RT-PCR showing modulation of claudin-1 mRNA transcript in SKOV-3 cells in response to LPA treatment for the times indicated. …”

Loss of the macrophage-TCR in the presence of functional T cells results in disorganized granulomas and CCL2 suppression in murine pulmonary tuberculosis. by Alexander W. Beham (196299)

“…<p>(<b>A</b>) TNF blockade decreases the number and size of macrophage clusters induced by <i>BCG</i> infection <i>in vitro</i>. …”

Structural properties of the complex formed by native rat Grp94 with IgG. by Andrea Pagetta (515998)

“…Peaks are numbered in decreasing order of intensity of the area. Spectra of a representative experiment of three others made on different occasions are shown. …”

Video_5_Automated contouring, treatment planning, and quality assurance for VMAT craniospinal irradiation (VMAT-CSI).mp4 by Eric Simiele (18336738)

“…Purpose<p>Create a comprehensive automated solution for pediatric and adult VMAT-CSI including contouring, planning, and plan check to reduce planning time and improve plan quality.…”

Video_4_Automated contouring, treatment planning, and quality assurance for VMAT craniospinal irradiation (VMAT-CSI).mp4 by Eric Simiele (18336738)

“…Purpose<p>Create a comprehensive automated solution for pediatric and adult VMAT-CSI including contouring, planning, and plan check to reduce planning time and improve plan quality.…”