Self-Healable, Injectable Hydrogel with Enhanced Clotrimazole Solubilization as a Potential Therapeutic Platform for Gynecology by Monika Gosecka (1607017)

“…Injectable, self-healing hydrogels with enhanced solubilization of hydrophobic drugs are urgently needed for antimicrobial intravaginal therapies. Here, we report the first hydrogel systems constructed of dynamic boronic esters cross-linking unimolecular micelles, which are a reservoir of antifungal hydrophobic drug molecules. …”

Self-Healable, Injectable Hydrogel with Enhanced Clotrimazole Solubilization as a Potential Therapeutic Platform for Gynecology by Monika Gosecka (1607017)

“…Injectable, self-healing hydrogels with enhanced solubilization of hydrophobic drugs are urgently needed for antimicrobial intravaginal therapies. Here, we report the first hydrogel systems constructed of dynamic boronic esters cross-linking unimolecular micelles, which are a reservoir of antifungal hydrophobic drug molecules. …”

Mean pancreas volume in the type 2 diabetes and control groups (error bars show standard error of the mean). by Mavin Macauley (736220)

ubH2A signal decreased when both USP21 variants are over-expressed. by Hiroshi Okuda (488740)

The polarization of a passive straight cable due to an extracellular field is anti-symmetric and decreases with the field frequency. by Florian Aspart (3366014)

siRNA-mediated knockdown of SPARC decreases SLUG expression in a p53-independent manner. by Nina Fenouille (149658)

Oral UOX decreased SUA (A), BUN (B) and Cr (C) (mean ± SD, n = 10). by Yu Yun (4710340)

A Single-Nucleotide Polymorphism of Human Neuropeptide S Gene Originated from Europe Shows Decreased Bioactivity by Cheng Deng (416051)

Spontaneous oxycodone withdrawal initially flattens NREM power rhythms, decreases low frequency and increases high frequency power. by Michael Gulledge (20577135)

2‑Ethylhexyl Diphenyl Phosphate and Its Hydroxylated Metabolites are Anti-androgenic and Cause Adverse Reproductive Outcomes in Male Japanese Medaka (Oryzias latipes) by Yu Li (183836)

“…In this study, we for the first time observed that EHDPP elicited androgen receptor (AR) antagonistic activity with a 50% inhibitory concentration of 37.5 μM. 2-Ethyl-5-hydroxyhexyl diphenyl phosphate was proved to be the dominant metabolite of EHDPP in Japanese medaka and elicited 3.1-fold stronger AR antagonistic activity than that of EHDPP. …”

2‑Ethylhexyl Diphenyl Phosphate and Its Hydroxylated Metabolites are Anti-androgenic and Cause Adverse Reproductive Outcomes in Male Japanese Medaka (Oryzias latipes) by Yu Li (183836)

“…In this study, we for the first time observed that EHDPP elicited androgen receptor (AR) antagonistic activity with a 50% inhibitory concentration of 37.5 μM. 2-Ethyl-5-hydroxyhexyl diphenyl phosphate was proved to be the dominant metabolite of EHDPP in Japanese medaka and elicited 3.1-fold stronger AR antagonistic activity than that of EHDPP. …”

Loss of FGFR2 Impaired Self-Renewal of Breast TICs, Resulting in a Decreased TIC Pool. by Sungeun Kim (105743)

SAHA Decreases HDAC 2 and 4 Levels <em>In Vivo</em> and Improves Molecular Phenotypes in the R6/2 Mouse Model of Huntington's Disease by Michal Mielcarek (195209)

“…To elucidate whether SAHA is a potent modifier of HDAC protein levels <em>in vivo</em>, we performed two independent mouse trials. Both WT and R6/2 mice were chronically treated with SAHA and vehicle. …”

liver tissue, stained with Masson´s trichrome staine, of (a) normal rats showing scant faint blue-stained fibrous in the portal area, (b) TAA-treated group showing strong blue-stai... by Sally A. El Awdan (710176)

Changes in the total protein content and free amino acid profile in N stressed cells are consistent with a decrease in N assimilation. by Steve Dagenais Bellefeuille (654383)

Video_1_Topoisomerase 2B Decrease Results in Diastolic Dysfunction via p53 and Akt: A Novel Pathway.MP4 by Rohit Moudgil (540119)

Video_1_Topoisomerase 2B Decrease Results in Diastolic Dysfunction via p53 and Akt: A Novel Pathway.MP4 by Rohit Moudgil (540119)

Figure S1 - The Dinoflagellate <i>Lingulodinium polyedrum</i> Responds to N Depletion by a Polarized Deposition of Starch and Lipid Bodies by Steve Dagenais Bellefeuille (654383)

Chronic Zinc Exposure Decreases the Surface Expression of NR2A-Containing NMDA Receptors in Cultured Hippocampal Neurons by Jia Zhu (135506)

“…Whole-cell and synaptic NR2A-mediated currents also decreased. By contrast, zinc did not affect NR2B, suggesting that chronic zinc exposure specifically influences NR2A-containg NMDARs. …”

Table_2_Decreased and Heterogeneous Neutralizing Antibody Responses Against RBD of SARS-CoV-2 Variants After mRNA Vaccination.docx by Pablo Hernández-Luis (12356716)