Quantitative RT-qPCR demonstrate that Tat complex modulates expression of C5, CRLF2, APBA1, and BDNF. by Loreto Carvallo (4167607)

“…Tat complex increased the expression of C5 at 24 and 48 hours, decreased the expression of CRLF2 at 24 and 48 hours, increased the expression of APBA1 at 48 hours and increased the expression of BDNF after 24 hours of PMA treatment. …”

Pathways illustrating the network of genomic loci involved with (A & B) Regions undergoing increase in 5mC content and (C & D) decrease in 5mC contents, upon simulated microgravity. by Basudev Chowdhury (2182760)

“…<p>Pathways illustrating the network of genomic loci involved with (A & B) Regions undergoing increase in 5mC content and (C & D) decrease in 5mC contents, upon simulated microgravity.…”

Population dynamics modeling of split^50cM <i>ClvR</i> V1 drive introduced at different release percentages, and an example illustrating the role that LOF alleles play in... by Georg Oberhofer (3401438)

“…A large number of individuals WT at each of these loci is now introduced into the modified population (release of 50%). …”

Curcumin induces phosphorylation of p38 MAPK and decreases phosphorylation of Akt in RPE cells. by Margrit Hollborn (394459)

“…As control, PDGF (10 ng/ml) was tested. <b>B.</b> The inhibitor of p38 MAPK activation, SB203580 (SB; 10 µM), decreased the curcumin-induced phosphorylation of p38 MAPK. …”

The neutral lipid stock inside epimastigotes decreases along time in serum-free medium. by Miria G. Pereira (212119)

EGFR/ERK signaling activity decreases throughout LEC elimination with endocytic activity dependency. by Kevin Yuswan (19845885)

Decreased Aβ oligomer immunoreactivity in APPxPS1 mice after treatment with hNGFP61S/R100E: polyclonal pAb A11 antibody. by Simona Capsoni (161132)

Aspirin decreases expression of NFκB and β-catenin in colon cancer cells. by Satya Pathi (301408)

“…<p>Decreased p65/p50 in RKO (A) and SW480 (B) cells. Cells were treated for 48 hr with 5 or 10 mM, and whole cell, nuclear and cytosolic extracts were analyzed by western blot analysis as described in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048208#s3" target="_blank">Experimental Procedures</a>. …”

Complex I activity is increased in cells with elevated NQO1 levels and is decreased by rotenone. by Jiyeong Kim (433042)

Alternative bounded and monotonically decreasing functions do not accurately fit the bias in the naïve SI. by Liron Sheintuch (12078310)

“…<p>(A-D) Fitting the naïve SI (blue) of simulated data using different types of bounded and monotonically decreasing functions with three free parameters. BAE (green; C) yields a more accurate estimation of the true SI (cyan) compared to an exponential function (red; A) or a power law (magenta; B). …”

GBE did not modify cell morphology but decreased reactive oxygen species (ROS) levels. by Virginie Rhein (243241)

“…<p>Morphological analysis of vector control and APP cells showed neuroblast-like morphology with differentiated perikaria (<i>arrows</i>) and occasional short neurites (<i>arrowheads</i>). <b>A</b>) Transfection of SH-SY5Y cells with cDNAs (pCEP4 vector) containing the vector alone or the entire coding region of wild-type human APP (APP cells) and <b>B</b>) GBE treatment (100 µg/ml; 24 h) did not significantly change general cell morphology. …”

MRI imaging and analysis, revealing decreased volume and thickness of placentas exposed to intrauterine inflammation. by Solange N. Eloundou (6551627)

Rapamycin decreases Schwann cell markers, whereas statin induces Schwann cell markers. by Andrea Preitschopf (629851)

Decreased knee bioluminescence was found with increased duration in an <i>in vivo</i> deterioration model. by Sarah E. Mailhiot (766685)

hESCs-Exo decreased cancer cell proliferation and increased cancer cell death. by Shufeng Zhou (398572)

Behavioral response to ambiguous conditioned fear cues is decreased in adult neurogenesis-deficient mice. by Lucas R. Glover (3912628)

Exposure to low CO₂ levels decreases ER cholesterol levels. by Nityanand Bolshette (17396845)

“…<b>(D, E)</b> The free cholesterol and cholesterol ester levels in the ER membrane from the cells as in <b>(C)</b>, were quantified with shotgun lipidomics analysis (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s007" target="_blank">S7 Fig</a> and <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s012" target="_blank">S5 Table</a>) (mean ± SE, <i>n</i> = 3 independent experiments, **<i>P</i> < 0.01, *<i>P</i> < 0.05, nonsignificant (ns) two-sided Student’s <i>t</i> test). …”

DHT increases whereas orchidectomy decreases the weight and cross sectional area of hindlimb muscles. by Young-Eun Yoo (323357)

“…<b>A:</b> In WT mice, DHT increased the GN weight by 7% (212.4±8.8 mg), whereas orchidectomy decreased it by 14% (171.4±9.0 mg) compared with control WT mice (198.4±5.5 mg). …”

Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4‑<i>b</i>]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Assoc... by Mary A. Foutz (20361830)

“…Pharmacokinetic studies indicated a half-life of 2 h, <i>C</i>_max of 35 μM, and no observed adverse effects at 1,000 mg kg^–1 dose in mice. …”

Disruption of FGFR1-Frs2/3 pathway decreases the number of support cells. by Kazuya Ono (513633)