<i>Mycobacterium tuberculosis</i> thymidylate synthase (ThyX) is a target for plumbagin, a natural product with antimycobacterial activity - Fig 2 by Apurba Sarkar (8399571)

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

The synchronous activity of SGN fiber populations is disrupted and their response to sound is decreased with increasing levels of <i>L</i>_<i>u</i> heterogeneity. by Maral Budak (6680351)

Measurement of mitochondrial superoxide anion production in HL-1 cells exposed for 12 or 72h to LG, NG, HG or IHG. by Patrick Mordel (17020879)

Velocity distribution at different openings (a) 25%; (b) 50%; (c) 75%; (d) 100%. by Weiqing Xu (1279959)

Mean CBD concentration (%) for duration of vegetative phase (DVP) and inflorescence fraction. by Torsten Schober (20485754)

CONSORT flowchart. by Jaskiran Kaur (160829)

Baseline characteristics of study subjects. by Jaskiran Kaur (160829)

Represents the levels of biomarkers as baseline and follow up in placebo and cholecalciferol group. by Jaskiran Kaur (160829)

Effect of cilostazol on liver GSH (A) and MDA (B) in TAA-induced fibrosis in rats. by Sally A. El Awdan (710176)

Effect of the Hill coefficient on estimates of <i>ε</i>_max (left column) and IC₅₀ (right column) for the logistic model with drug applied to the growth rate <... by Hope Murphy (8843516)

Partial correlation of <i>ε</i>_max (left column) and IC₅₀ (right column) estimates at 10 days and 20 days (first and second bar of each color, respectively) o... by Hope Murphy (8843516)

Development of a CRISPR/Cas-Based Detection Platform for Tracking Decreased Susceptibility to Cephalosporins in Neisseria gonorrheae by Ziyuan Zhao (2889005)

“…MIRCA enables multiplex detection of <i>Ng</i> and single-nucleotide polymorphisms in resistance-associated genes within 40 min, with high specificity and sensitivity (10–20 copies/reaction). …”

Longer polyQ sequences decrease the nuclear localization of AR in the absence of hormone. by Carlos M. Roggero (11909585)

Titanate Nanosheets/Cellulose Composite Showing Improved Crystallinity and Decreased Water Wettability by Gamma-Irradiation by Yaowaluk Tariwong (22630109)

Representative immunohistochemistry images of PCNA expression in renal tissues among CG, NG, NVG, and NVRG (×400). by Jian-feng Li (8667645)

Sensitivity analysis of 50:50 model. by Rachael Miller Neilan (10678614)

“…<p>A sensitivity analysis was conducted on the 50:50 model with constant 120 pA current to determine the sensitivity of pain output to select model parameters before injury (t = 10), during injury (t = 105), and after injury (t = 240). …”

Projection of testing costs under different cost scenarios for medical supplies and personnel (USD). by Nelmo Jordão Manjate (16324619)

Subjects:

Summary of resources per type of test and costs for Ag-RDT tests (USD 2020). by Nelmo Jordão Manjate (16324619)

Subjects: