Data_Sheet_3_Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos.PDF by Auke B. C. Otten (8965244)

“…Morphant embryos displayed abnormal development of the eye, brain, heart, and muscle, as well as a 50 ± 22% decrease in ATP production. Transcriptome analysis revealed a decrease in protein-encoding transcripts from the heavy strand of the mtDNA, and down-regulation of genes involved in haem production and the metabolism of metabolites, which appear to trigger increased rRNA and tRNA synthesis in the nucleoli. …”

Data_Sheet_2_Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos.pdf by Auke B. C. Otten (8965244)

“…Morphant embryos displayed abnormal development of the eye, brain, heart, and muscle, as well as a 50 ± 22% decrease in ATP production. Transcriptome analysis revealed a decrease in protein-encoding transcripts from the heavy strand of the mtDNA, and down-regulation of genes involved in haem production and the metabolism of metabolites, which appear to trigger increased rRNA and tRNA synthesis in the nucleoli. …”

Data_Sheet_4_Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos.PDF by Auke B. C. Otten (8965244)

“…Morphant embryos displayed abnormal development of the eye, brain, heart, and muscle, as well as a 50 ± 22% decrease in ATP production. Transcriptome analysis revealed a decrease in protein-encoding transcripts from the heavy strand of the mtDNA, and down-regulation of genes involved in haem production and the metabolism of metabolites, which appear to trigger increased rRNA and tRNA synthesis in the nucleoli. …”

Test scores and ordering costs. by Jinghong Ma (1755838)

Displacement of site marker ligands bound to HSA in presence of increasing PS concentrations. by Shevin R. Feroz (468333)

“…Spectra marked as ‘a’, ‘b’, ‘c’ and ‘d’ refer to 10 µM BR, 10 µM HSA, 50 µM PS and PS–HSA (5∶1) complex, respectively. …”

Models' performance evaluation by therapy line. by Mattia C. F. Prosperi (195763)

“…<p>Plot (<i>panel A</i>) of AUC of 10-fold CV for models (i), (ii) and (iv) by stratifying for therapy line (SD8G). …”

Phage ELISA, SPR and kinetic data for top hits from third round ofaffinity maturation. by John D. Steemson (510975)

“…While the k_on for both AM3L15 and AM3L09 are essentially the same, the difference in dissociation constant can be attributed to a substantial decrease (10-fold) in k_off. Separate on and off rates could not be determined from the AM2EP06 data.…”

Biological processes affected by WA treatment in MDA-MB-231 and MCF-7 cells. by Katarzyna Szarc vel Szic (519230)

“…Only genes that have a log₂ fold change (FC)≥1 or ≤1 between control and WA-treated samples and have a p-value<0.001 are plotted. …”

Lovastatin inhibits VEGF induced activation of AKT and its downstream targets. by Tong T. Zhao (361937)

“…Phosphorylation level of AKT decreased with lovastatin treatment in a dose dependent manner. …”

Autophagy-Associated Atrophy and Metabolic Remodeling of the Mouse Diaphragm after Short-Term Intermittent Hypoxia by Christian Giordano (760069)

“…</p><p>Results</p><p>After 4 days of IH, the diaphragm alone demonstrated significant atrophy (30% decrease of myofiber size) together with increased LC3B-II protein (2.4-fold) and mRNA markers of the autophagy pathway (LC3B, Gabarapl1, Bnip3), whereas active calpain and E3 ubiquitin ligases (MuRF1, atrogin-1) were unaffected in both muscles. …”

BIX-01294 attenuates H3K9 methylation and derepresses transcriptional regulation of target genes. by Jolene Caifeng Ho (4597606)

“…<p>(A) Western blots showing decrease in H3K9me1 (MCF-7) and H3K9me2 levels (MCF-7 and HeLa) after 48 and 24 hours respectively in the indicated treatments. …”

Complete Suppression of Blinking and Reduced Photobleaching in Single MEH-PPV Chains in Solution by Suguru Onda (1281132)

“…Adsorption of the chains onto a substrate in the solution leads to 34% decrease in fluorescence intensity (quantum efficiency), five-fold increase in the rate of photobleaching and appearance of blinking. …”

Other glycines substitutions that destabilize BH4-Bcl-2’s by Giovanni Monaco (452223)

“…Data points represent means ± SEM. * indicates a statistically significant difference from vehicle control.…”

table_1_In Utero and Postnatal Propylthiouracil-Induced Mild Hypothyroidism Impairs Maternal Behavior in Mice.DOCX by Miski Aghnia Khairinisa (5213834)

“…As expected, locomotor and cognitive functions in these mice were disrupted in a PTU dose-dependent manner. On postpartum day 2, dams who had been exposed 50 ppm PTU during in utero and postnatal periods displayed a significantly longer time identifying the first pup and returning all three pups back to the nest, less time nursing, and decreased licking behavior. …”

table_2_In Utero and Postnatal Propylthiouracil-Induced Mild Hypothyroidism Impairs Maternal Behavior in Mice.DOCX by Miski Aghnia Khairinisa (5213834)

“…As expected, locomotor and cognitive functions in these mice were disrupted in a PTU dose-dependent manner. On postpartum day 2, dams who had been exposed 50 ppm PTU during in utero and postnatal periods displayed a significantly longer time identifying the first pup and returning all three pups back to the nest, less time nursing, and decreased licking behavior. …”

image_1_In Utero and Postnatal Propylthiouracil-Induced Mild Hypothyroidism Impairs Maternal Behavior in Mice.EPS by Miski Aghnia Khairinisa (5213834)

“…As expected, locomotor and cognitive functions in these mice were disrupted in a PTU dose-dependent manner. On postpartum day 2, dams who had been exposed 50 ppm PTU during in utero and postnatal periods displayed a significantly longer time identifying the first pup and returning all three pups back to the nest, less time nursing, and decreased licking behavior. …”

STAT3 represses Jmjd3 expression in glioblastoma stem cells. by Maureen M. Sherry-Lynes (3911521)

“…E. S3I-201 treatment decreases NCor binding at the Jmjd3 promoter. GS6-22 cells were treated with S3I-201 (50 μM) or DMSO for 4 hours, fixed, lysed, and sonicated. …”

ToxCast™Phase I chemical activity across cytotoxicity and differentiation ES cell assay endpoints. by Kelly J. Chandler (218453)

“…Unsupervised, two-dimensional hierarchical clustering of 320 ToxCast chemicals across four ES cell assay endpoints (cytotoxicity increase, cytotoxicity decrease, differentiation increase, differentiation decrease) and 4 doses each using Euclidean distance for measure and Ward's method for linkage analysis (A). …”

The exocyst is required for cell cycle progression in trypanosomes. by Cordula M. Boehm (3689848)

“…Sec15::RNAi cells have a ∼50% decrease to Sec15::HA 48h post induction, whilst expression of Exo99 remains stable, and <i>vice versa</i>. …”

DataSheet_1_Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis via the inhibition of the SIRT3/... by Jinlan Xie (12917417)

“…The addition of 2 mmol/l BHB improved ATP production, mitochondrial biosynthesis, and endocytic albumin function, while cell apoptosis was reduced in HK2 cells. The addition of 50 ng/ml insulin resulted in the decreased expression of SMCT1 along with an impaired mitochondrial function, decreased ATP production, and increased apoptosis. …”