S3 Dataset - by Shinichi Chisada (15354141)

“…Our results revealed that the medaka <i>rad50</i> mutation concurrently reproduced tumorigenesis (8 out of 10 <i>rad50</i>^<i>Δ2/+</i> medaka), had a decrease in median survival time (65.7 ± 1.1 weeks in control vs. 54.2 ± 2.6 weeks in <i>rad50</i>^<i>Δ2/+</i> medaka, <i>p</i> = 0.001, Welch’s <i>t</i>-test), exhibited semi-lethality in <i>rad50</i>^{<i>Δ2/Δ2</i>} medaka and most of the major ataxia-telangiectasia phenotypes, including ataxia (rheotaxis ability was lower in <i>rad50</i>^<i>Δ2/+</i> medaka than in the control, Mann–Whitney U test, <i>p</i> < 0.05), and telangiectasia (6 out of 10 <i>rad50</i>^<i>Δ2/+</i> medaka). …”

S2 Dataset - by Shinichi Chisada (15354141)

“…Our results revealed that the medaka <i>rad50</i> mutation concurrently reproduced tumorigenesis (8 out of 10 <i>rad50</i>^<i>Δ2/+</i> medaka), had a decrease in median survival time (65.7 ± 1.1 weeks in control vs. 54.2 ± 2.6 weeks in <i>rad50</i>^<i>Δ2/+</i> medaka, <i>p</i> = 0.001, Welch’s <i>t</i>-test), exhibited semi-lethality in <i>rad50</i>^{<i>Δ2/Δ2</i>} medaka and most of the major ataxia-telangiectasia phenotypes, including ataxia (rheotaxis ability was lower in <i>rad50</i>^<i>Δ2/+</i> medaka than in the control, Mann–Whitney U test, <i>p</i> < 0.05), and telangiectasia (6 out of 10 <i>rad50</i>^<i>Δ2/+</i> medaka). …”

S5 Dataset - by Shinichi Chisada (15354141)

“…Our results revealed that the medaka <i>rad50</i> mutation concurrently reproduced tumorigenesis (8 out of 10 <i>rad50</i>^<i>Δ2/+</i> medaka), had a decrease in median survival time (65.7 ± 1.1 weeks in control vs. 54.2 ± 2.6 weeks in <i>rad50</i>^<i>Δ2/+</i> medaka, <i>p</i> = 0.001, Welch’s <i>t</i>-test), exhibited semi-lethality in <i>rad50</i>^{<i>Δ2/Δ2</i>} medaka and most of the major ataxia-telangiectasia phenotypes, including ataxia (rheotaxis ability was lower in <i>rad50</i>^<i>Δ2/+</i> medaka than in the control, Mann–Whitney U test, <i>p</i> < 0.05), and telangiectasia (6 out of 10 <i>rad50</i>^<i>Δ2/+</i> medaka). …”

Stable swimming of wildtype. by Shinichi Chisada (15354141)

“…Our results revealed that the medaka <i>rad50</i> mutation concurrently reproduced tumorigenesis (8 out of 10 <i>rad50</i>^<i>Δ2/+</i> medaka), had a decrease in median survival time (65.7 ± 1.1 weeks in control vs. 54.2 ± 2.6 weeks in <i>rad50</i>^<i>Δ2/+</i> medaka, <i>p</i> = 0.001, Welch’s <i>t</i>-test), exhibited semi-lethality in <i>rad50</i>^{<i>Δ2/Δ2</i>} medaka and most of the major ataxia-telangiectasia phenotypes, including ataxia (rheotaxis ability was lower in <i>rad50</i>^<i>Δ2/+</i> medaka than in the control, Mann–Whitney U test, <i>p</i> < 0.05), and telangiectasia (6 out of 10 <i>rad50</i>^<i>Δ2/+</i> medaka). …”

Unstable swimming of mutant. by Shinichi Chisada (15354141)

“…Our results revealed that the medaka <i>rad50</i> mutation concurrently reproduced tumorigenesis (8 out of 10 <i>rad50</i>^<i>Δ2/+</i> medaka), had a decrease in median survival time (65.7 ± 1.1 weeks in control vs. 54.2 ± 2.6 weeks in <i>rad50</i>^<i>Δ2/+</i> medaka, <i>p</i> = 0.001, Welch’s <i>t</i>-test), exhibited semi-lethality in <i>rad50</i>^{<i>Δ2/Δ2</i>} medaka and most of the major ataxia-telangiectasia phenotypes, including ataxia (rheotaxis ability was lower in <i>rad50</i>^<i>Δ2/+</i> medaka than in the control, Mann–Whitney U test, <i>p</i> < 0.05), and telangiectasia (6 out of 10 <i>rad50</i>^<i>Δ2/+</i> medaka). …”

Use of thermography to guide amputation levels. by Mario Aurelio Martínez-Jiménez (5963564)

“…<p>Thermographic imaging can be used as an adjunct to determine amputation levels in severely burned patients. A 24-year old patient with fourth degree burns in approximately 50% of his body surface area because of direct fire was admitted to the burn unit (A). …”

bpV(pic) reduces neuronal autophagosome aggregation. by Chandler L. Walker (188845)

“…Treatment with bpV promoted a decrease in neuronal autophagosome clustering. …”

Effects of malaria on the proteome in mammary gland tissue of postpartum mice. by Mamoru Niikura (4103791)

“…<p>(A and B) Venn diagram of protein levels in mammary gland tissue of uninfected and infected postpartum mice that changed 0.5-fold (A) or 2-fold (B) compared with uninfected virgin mice. …”

Imaging β-gal activity <i>in vivo</i>. by Li Liu (75607)

“…Curves show signal for specific regions of interest (inset) with highest signal from the <i>lacZ</i> tumor (blue curve), then contralateral WT tumor (red) and lowest for skin on the upper back (green) each of which decreased with half-life of about 2 mins. Corresponding histology and β-gal expression profiles are shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0012024#pone.0012024.s002" target="_blank">Figure S2</a>.…”

Effect of crizotinib and alectinib on stimulus preference of retinal ganglion cells. by Toshiyuki Ishii (53332)

“…<p>(A and B) Post-stimulus time histogram before (pre), during (crizotinib), and after (wash) the application of 1.0μM of crizotinib in an OFF-cell (A) and in an ON-OFF cell (B). …”

Ruthenium and Osmium Complexes of Phosphine-Porphyrin Derivatives as Potential Bimetallic Theranostics: Photophysical Studies by Pierre D. Harvey (1406404)

“…These favorable features are mostly associated with the presence of their long chain (i.e., ∼ 1 nm) separating the two functional units. Interestingly, a decrease in emission intensity and lifetimes (up to 35-fold) has been observed, which was ascribed to a small heavy atom effect. …”

MO-SAM segmentation performance using the Grid method in arid/semi-arid landscape. by Qitong Wang (15279695)

“…The point prompts, annotations, pixel intervals, and predictions are shown in light blue and the PI is 50, 35, 20; the IoU scores from left to right are 83.99, 81.05, and 44.19 percent, indicating a decrease in performance as the number and density of gridded point prompts increases In the third row, Platinum Group Elements, the point prompts, annotations, pixel intervals, and predictions are shown in purple. …”

Age-dependent changes in biometrics indicate senescence in the European Blackbird <i>Turdus merula</i> by Piotr Piliczewski (5277803)

“…<p><b>Capsule:</b> A 19-year study of European Blackbirds <i>Turdus merula</i> confirms that senescence is associated with a decrease in condition measured by wing length but bills become progressively longer with age.…”

MPA gap analysis results based upon alternate choices of datasets. by Casey C. O'Hara (3997529)

“…Scenario 3, still using 2015 AquaMaps data, drops the presence threshold to zero, showing an expected decrease in gap species, but also a decrease in species with 5% or greater protected range. …”

Effects of single-agent vemurafenib on BRAF mutated NSCLC cells. by Monika Joshi (695076)

“…<p><b>A:</b> Long-term growth assay, 7 days post treatment with vehicle-D (DMSO), vemurafenib 50 nM, 500 nM, 5000 nM in both HCC364 and H1755 cells. …”

Modeling the RA Morphogen Gradient by Richard J White (82003)

“…In both panels, the dashed curves show the effects of a 2-fold decrease in RA production. In (B), <i>cyp26a1</i> is taken to be constant over the interval 0 < <i>x</i> < 360 μm, whereas in (C), it is regulated as prescribed by the model. …”

Presentation1.pptx by Julien Leuthold (4921660)

“…Kane Megamullion and Hess Deep clinopyroxene core1 primocrysts and their plagioclase inclusions indicate crystallization from high temperature basalt (>1,160 and >1,200°C, respectively), close to clinopyroxene saturation temperature (<50% and <25% crystallization). Step-like compatible Cr (and co-varying Al) and incompatible Ti, Zr, Y and rare earth elements (REE) decrease from anhedral core1 to overgrown core2, while Mg# and Sr/Sr^* ratios increase. …”

Table_1_Age- and Sex-Specific Characteristics of Right Ventricular Compacted and Non-compacted Myocardium by Cardiac Magnetic Resonance.docx by Anna Réka Kiss (10582169)

“…Four different age groups were established with equal numbers of males and females: Group A (n = 50, 20-29 years, mean age: 24.3 ± 3.2 years), Group B (n = 50, 30-39 years, mean age: 33.6 ± 2.6 years), Group C (n = 50, 40-49 years, mean age: 44.7 ± 2.7 years), and Group D (n = 50, ≥50 years, mean age: 55.1 ± 3.9 years). …”

Astrocytic volume changes evoked by increased extracellular K⁺ concentration in the cortex of GFAP/EGFP and GFAP/EGFP/α-Syn^−/− mice. by Miroslava Anderova (155561)

“…The changes of astrocytic volume during washout were evaluated in each individual cell and were expressed as an average percent of cell volume increase/decrease related to the maximal volume after 30 minutes of aCSF_K+10 (<b>C right</b>) or after 20 minutes of aCSF_K+50 application (<b>D right</b>); these values were set as 0%. …”

Quantification of localization and signaling during endocytosis. by Charanya Rengarajan (511093)

“…Co-transfection of Hsc70 and Fgf8 led to 8-fold increase of phosphorylation of Erk. Treatment with Bafilomycin A1 leads to a 14-fold increase of double phosphorylated Erk1/2 level. …”