Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues by Srinath Pashikanti (2638048)

“…Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five native G-protein coupled receptors (S1P1–5) to regulate cell growth, survival, and proliferation. …”

Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues by Srinath Pashikanti (2638048)

“…Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five native G-protein coupled receptors (S1P1–5) to regulate cell growth, survival, and proliferation. …”

Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues by Srinath Pashikanti (2638048)

“…Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five native G-protein coupled receptors (S1P1–5) to regulate cell growth, survival, and proliferation. …”

Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues by Srinath Pashikanti (2638048)

“…Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five native G-protein coupled receptors (S1P1–5) to regulate cell growth, survival, and proliferation. …”

Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues by Srinath Pashikanti (2638048)

“…Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five native G-protein coupled receptors (S1P1–5) to regulate cell growth, survival, and proliferation. …”

Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues by Srinath Pashikanti (2638048)

“…Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five native G-protein coupled receptors (S1P1–5) to regulate cell growth, survival, and proliferation. …”

Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues by Srinath Pashikanti (2638048)

“…Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five native G-protein coupled receptors (S1P1–5) to regulate cell growth, survival, and proliferation. …”

Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues by Srinath Pashikanti (2638048)

“…Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five native G-protein coupled receptors (S1P1–5) to regulate cell growth, survival, and proliferation. …”

Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues by Srinath Pashikanti (2638048)

“…Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five native G-protein coupled receptors (S1P1–5) to regulate cell growth, survival, and proliferation. …”

Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues by Srinath Pashikanti (2638048)

“…Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five native G-protein coupled receptors (S1P1–5) to regulate cell growth, survival, and proliferation. …”

Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues by Srinath Pashikanti (2638048)

“…Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five native G-protein coupled receptors (S1P1–5) to regulate cell growth, survival, and proliferation. …”

Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues by Srinath Pashikanti (2638048)

“…Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five native G-protein coupled receptors (S1P1–5) to regulate cell growth, survival, and proliferation. …”

Experimental Setup. by Mengnan Wu (769253)

SidK reduces the flexibility of the A-subunit and its binding affinity for TNP-ATP. by Jianhua Zhao (531939)

“…In V-ATPase without SidK (-SidK), the C-terminal region of the A-subunit (A_CT) in the ‘open’ conformation (A_open) has lower density compared to the A-subunit in the ‘tight’ or ‘loose’ conformations (A_tight, A_loose). …”

Table_2_“If you weren't connected to the Internet, you were not alive”: experience of using social technology during COVID-19 in adults 50+.DOCX by Katrina Ling (13981107)

Table_1_“If you weren't connected to the Internet, you were not alive”: experience of using social technology during COVID-19 in adults 50+.DOCX by Katrina Ling (13981107)

Table 1. Distribution of the decreased-susceptibility-to-DDAC phenotype in the study panel (n = 168) according to the year of strain isolation, animal species, and sample type. by Marine Pottier (14099133)

Inhibition of the interactions of syndecan-1 with integrins αvβ3 and αvβ5 was inhibited with the synstatin and gene or protein expression was measured after 48 hours. by Somali Chaterji (527203)

“…<p>(A–C) Decreased expression of vSMC-specific differentiation markers; (D–F) Increased expression of inflammatory cytokine, MCP-1, and, adhesion receptors, ICAM-1 and VCAM-1.…”

Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines by Christopher R. Bodle (4115221)

“…Using high-throughput screening, a chemical library containing natural products was interrogated for inhibition of the RGS17–Gα_o interaction. …”

Re-emergence of Rabies in the Guangxi Province of Southern China by Hai-Bo Tang (638248)

“…Alignment of deduced amino acids revealed that the mature G protein has four substitutions A96S, L132F, N436S, and A447I specific to group I, and 13 substitutions T90M, Y168C, S204G, T249I, P253S, S289T, V332I, Q382H, V427I, L474P, R463K Q486H, and T487N specific to group II, coinciding with the phylogenetic analysis of the isolates.…”