بدائل البحث:
ng decrease » nn decrease (توسيع البحث), _ decrease (توسيع البحث), gy decreased (توسيع البحث)
we decrease » _ decrease (توسيع البحث), nn decrease (توسيع البحث), mean decrease (توسيع البحث)
a decrease » _ decrease (توسيع البحث), _ decreased (توسيع البحث), _ decreases (توسيع البحث)
b decrease » _ decrease (توسيع البحث), b1 decreased (توسيع البحث), ob decreased (توسيع البحث)
16 b » 16 _ (توسيع البحث), 1 b (توسيع البحث), 6 b (توسيع البحث)
ng decrease » nn decrease (توسيع البحث), _ decrease (توسيع البحث), gy decreased (توسيع البحث)
we decrease » _ decrease (توسيع البحث), nn decrease (توسيع البحث), mean decrease (توسيع البحث)
a decrease » _ decrease (توسيع البحث), _ decreased (توسيع البحث), _ decreases (توسيع البحث)
b decrease » _ decrease (توسيع البحث), b1 decreased (توسيع البحث), ob decreased (توسيع البحث)
16 b » 16 _ (توسيع البحث), 1 b (توسيع البحث), 6 b (توسيع البحث)
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Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A<sub>3</sub> Adenosine Receptor Positive Allosteric Modulators
منشور في 2022"…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [<sup>35</sup>S]GTPγS binding <i>E</i><sub>max</sub>, with only <b>12b</b> trending toward decreasing the agonist EC<sub>50</sub>. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …"
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279
Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A<sub>3</sub> Adenosine Receptor Positive Allosteric Modulators
منشور في 2022"…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [<sup>35</sup>S]GTPγS binding <i>E</i><sub>max</sub>, with only <b>12b</b> trending toward decreasing the agonist EC<sub>50</sub>. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …"
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280