Minimum quorum sensing inhibitory concentrations (MQSICs), minimum inhibitory concentrations (MICs), and concentrations inhibiting 50% of violacein production (IC50s) of compounds... by Jean Paul Dzoyem (6424445)

Subjects:

TRIM5 restriction of HIV-1 has decreased during evolution leading to humans. by Michael Emerman (12304)

“…<p>The shading of the rectangle represents the degree that TRIM5 will limit infection of HIV-1 (darker color means TRIM5 decreases HIV-1 infection more) and the X-axis indicates time in millions of years from the present. …”

Velocity distribution at different openings (a) 25%; (b) 50%; (c) 75%; (d) 100%. by Weiqing Xu (1279959)

Elevated S100A8 level in BALF is associated with an increase of BALF neutrophils and a decrease of physiological function. by Do Hyung Kim (739231)

sC5b-9 patients decrease in patients treated with mycophenolate mofetil. by Joshua M. Thurman (517193)

“…<p>The levels of (A) Ba and (B) Bb did not change over the course of the study (n = 19 for all time-points). (C) The levels of sC5b-9 decreased over time (P < 0.001 by linear regression; n = 19 for all time-points). …”

An association between decreasing incidence of invasive non-typhoidal salmonellosis and increased use of antiretroviral therapy, Gauteng Province, South Africa, 2003–2013 by Karen H. Keddy (833179)

“…</p><p>Results</p><p>From 2003–2013, the incidence of iNTS per 100,000 population per year decreased from 5.0 to 2.2 (p < .001). From 2004 to 2013, the incidence per 100,000 population of HIV viral load testing increased from 75.2 to 3,620.3 (p < .001). …”

Evolutionary History of Atmospheric CO₂ during the Late Cenozoic from Fossilized <i>Metasequoia</i> Needles by Yuqing Wang (110531)

“…According to former research, this is a time when global temperature decreased sharply. …”

NAS (NAFLD Activity Score) of liver tissue of mice in each group after 8 weeks of treatment with either vehicle (V) or Kylo-0603 (0.1-10 mg/kg/day). by Xueqin lu (22250795)

Point cell model behavior. by Evan Cudone (5768813)

The injectable contraceptives depot medroxyprogesterone acetate and norethisterone enanthate substantially and differentially decrease testosterone and sex hormone binding globulin... by Chanel Avenant (409756)

“…<p dir="ltr">HIV acquisition risk with norethisterone (NET) enanthate (NET-EN) is reportedly less than for depo-medroxyprogesterone acetate intramuscular (DMPA-IM). We investigated the effects of these progestin-only injectable contraceptives on serum testosterone and sex hormone binding globulin (SHBG) levels, since these may play a role in sexual behavior and HIV acquisition. …”

MiR-129-5p levels were decreased in mouse depression models. by Qiaozhen Qin (13159201)

“…</b> Relative expression of miR-129-5p in the control and CRS groups. <b>M.</b> Relative expression of miR-129-5p in the CTX, HIP, and HB of control and CRS mice. …”

Host population bottlenecks decrease microbiome diversity. by Michael Ørsted (5926028)

High fat diet decreased tumor latency but did not affect survival in MMTV-PyMT transgenic mice. by Katherine V. Clark-Knowles (368164)

Extracellular adenosine modulates host-pathogen interactions through regulation of systemic metabolism during immune response in <i>Drosophila</i> by Adam Bajgar (730380)

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

Linear decrease of delta power (1.1–5.0 Hz) across the first three sleep cycles in the cortical, hippocampal and scalp recordings. by Fabio Moroni (34208)

Compound CID 9998128 Is a Potential Multitarget Drug for Alzheimer’s Disease by Nguyen Quoc Thai (5348798)

“…We have probed small molecule compound CID 9998128 as a potential multitarget drug for the Alzheimer’s disease (AD) using <i>in silico</i> and <i>in vitro</i> experiments. …”

Compound CID 9998128 Is a Potential Multitarget Drug for Alzheimer’s Disease by Nguyen Quoc Thai (5348798)

“…We have probed small molecule compound CID 9998128 as a potential multitarget drug for the Alzheimer’s disease (AD) using <i>in silico</i> and <i>in vitro</i> experiments. …”

Tryptophan and metabolite alterations in response to a control diet or a diet containing MCOA. by Natalie E. Diether (16705804)