Discovery of Novel Thiophene-Based Baloxavir Derivatives as Potent Cap-Dependent Endonuclease Inhibitors for Influenza Treatment by Yongzhi Chen (172975)

“…Among them, <b>ATV2301</b> exhibited an excellent anti-influenza activity (EC₅₀, H1N1 = 1.88 nM, H3N2 = 4.77 nM), a higher safety index (SI, H1N1 = 18218, H3N2 = 7180), and a remarkably improved oral bioavailability (<i>F</i> = 71.60%). …”

Discovery of Novel Thiophene-Based Baloxavir Derivatives as Potent Cap-Dependent Endonuclease Inhibitors for Influenza Treatment by Yongzhi Chen (172975)

“…Among them, <b>ATV2301</b> exhibited an excellent anti-influenza activity (EC₅₀, H1N1 = 1.88 nM, H3N2 = 4.77 nM), a higher safety index (SI, H1N1 = 18218, H3N2 = 7180), and a remarkably improved oral bioavailability (<i>F</i> = 71.60%). …”

Supplemental figure S3 from Movements and residency of Caribbean reef sharks at a remote atoll in Belize, Central America by Ivy E. Baremore (11204064)

Confirmation of berberine by FTIR and NMR. by Hammad Ismail (4227988)

Fig 5 - by Katharina Riebenbauer (10726250)

NCOA4 is downregulated in human CCA tissues and is correlated with poor prognosis. by Wenlong Shen (9313937)

Placental gene expression at E9.5 and E11.5. by Hui Zhao (7395)

Data_Sheet_1_Evaluating the Potential Benefit of a Combined Weight Loss Program in Dogs and Their Owners.docx by J. Rebecca Niese (10671678)

Online supplementary data from Projecting a second wave of COVID-19 in Japan with variable interventions in high-risk settings by Sung-mok Jung (10457737)

“…Projections showed that a 50% decrease in the high-risk transmission is required to keep <i>R</i> < 1 in both locations—a level necessary to maintain control of the epidemic and minimize the risk of resurgence.…”

Comparison of VO₂ max (ml/kg/min) between the DM and HC. by Uzair Abbas (18517982)

<i>malayi</i> N-AChR requires additional accessory proteins and has unchanged pharmacology compared to other clade III N-AChR. by Jennifer D. Noonan (14117157)

Experiment procedures. by Hui-Ya Chen (13919141)

DataSheet_1_Investigating miR-9 as a mediator in laryngeal cancer health disparities.docx by Christina Gobin (15181795)

“…Reducing miR-9 in UM-SCC-10A cells resulted in increased cellular migration (p < 0.05), increased proliferation (p < 0.05) and decreased sensitivity to cisplatin (p < 0.01). …”

Conjugated linoleic acid as a novel insecticide targeting the agricultural pest <i>Leptinotarsa decemlineata</i> - Fig 3 by Justin Clements (2180824)

Effects of Topper Training on psychosocial problems, self-esteem, and peer victimisation in Dutch children: A randomised trial by Lilian Vliek (8053037)

“…We examined the effectiveness of a transdiagnostic intervention, called Topper Training: a cognitive behavioural intervention in the peer group with parents included, that targets both internalising and externalising behaviour problems. …”

Data_Sheet_1_Sex-Specific Associations of Diabetes With Brain Structure and Function in a Geriatric Population.PDF by Elias G. Thomas (12965714)

“…Introduction<p>Globally, women with dementia have a higher disease burden than men with dementia. …”

The role of IRF-1 in mediating T-cell immune imbalance in systemic lupus erythematosus and the construction of a diagnostic model by Zichen Huang (6587885)

“…The role of interferon regulatory factor-1 (IRF-1) remains unclear. We integrated single-cell transcriptomes (scRNA-seq; GSE254176), 6 bulk transcriptomic datasets (1079 SLE patients, 137 controls, GSE72326 and GSE61635 were merged as training datasets, including 256 SLE patients and 50 controls), and clinical samples (70 SLE patients and 58 controls). …”

Ab-specific variations in neutralization potency against HIV-1 strains assigned to different neutralization tiers. by Caio Foulkes (20592250)

Preparation and exchange transfusion effect of a double polymerization human umbilical cord hemoglobin of red blood cell substitute by Wentao Zhou (12094169)

“…The molar ratio of GDA and DBBF-CHb was 7:1, the content of dimer is (8.23±0.98)%, MetHb increased as the molar ratio of GDA and DBBF-CHb increasing, the P50 and Hill coefficient decreased as the molar ratio of GDA to DBBF-CHb increasing. …”

Symptoms self-reported and/or documented in the electronic health record during the acute COVID-19 illness, by hospitalization status and age group. by Chelsea S. Lutz (16001569)