Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma by Zhihao Liu (419349)

“…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …”

Results on the trimmed datasets with a decreasing number of papers per author available for training and testing. by Leonard Bauersfeld (16475015)

PiCRUST prediction of the functional potential of a microbial community based on 16S rRNA gene sequencing data. by Jun Ho Song (1675123)

<i>RTTN</i>-mutated organoids exhibit decreased proliferation and increased cell death at early stages. by Justine Guguin (9088672)

Elevated IDO activity in HD mouse brains is decreased by <i>ex-vivo</i> iron chelation. by David W. Donley (3111198)

“…<p>Mouse pups were supplemented with carbonyl iron from postnatal days 10–17 and then were sacrificed at 14 weeks of age. <b>A.</b> Striatal IDO activity is increased in N171-82Q HD mice and significantly decreased by <i>ex vivo</i> iron (III) chelation (50 μM deferoxamine). …”

Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4‑<i>b</i>]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Assoc... by Mary A. Foutz (20361830)

“…Mitochondrial uncouplers such as BAM15 increase respiration and energy expenditure and have potential in treating a variety of metabolic diseases. In this study, we disclose the structure–activity relationship profile of 6-substituted [1,2,5]oxadiazolo[3,4-<i>b</i>]pyridin-7-ol derivatives of BAM15. …”

Adaptation of SARS-CoV-2_Engl2 to VeroE6 and selection of decreased RDV sensitivity. by Agnieszka M. Szemiel (10196243)

Table 1_A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity.xls by Wen Wang (6570)

“…Specifically, α-Conotoxins [D1G, ΔQ14] LvIC, identified from Conus lividus, have demonstrated strong activity on α6β4* nAChRs in vitro. …”

Design of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor by Beatrice Noce (16540800)

Subjects:

Confocal imaging of MIN6 in the context of cell proliferation, as well as insulin, C-peptide, and glucagon levels after treatment with investigated leucettines. by Barbara Pucelik (2988795)

Subjects:

Chronic high glucose induces apoptosis and proteasome activities decrease in INS-1E cells. by Christophe Broca (538652)

Experimental outline. by Melissa A. MacIver (12850566)

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Table_1_Decreasing the carbon footprint of food through public procurement—A case study from the municipality of Härnösand.XLSX by Mari Kjellberg (20130183)

“…This study examines alternative purchase processes that may decrease the carbon footprint of publicly procured food through a case study of a municipality in the Northern part of Sweden. …”

Lethal time (mean LT₅₀ and LT₉₀ with 95% confidence limits) for aphid populations from different agroecological zones exposed to six entomopathogenic fungal i... by Aime Cheoh Enoh (20141758)

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Pre-match open aortic group. by Tomi Obafemi (12328433)

“…However, the incidence of post-op ventilator associated pneumonia (VAP) decreased from 5.0% to 2.1% (p = 0.003) and post-op urinary tract infections (UTIs) from 8.3% to 3.6% (p<0.001). …”

Inhibiting Gamma-secretase activity without interfering in Notch signaling: Decreasing the inflammatory response in patients with cutaneous leishmaniasis by Lucas Carvalho (3093042)

“…</b>Data from RNASeq (25 CL lesions) was used for correlation matrix between components of gamma-secretase complex and <i>NFKB1, NFKB2, RELA, TNF, IL6, IL1B, IL10, CXCL9</i>and <i>GZMB</i>genes. …”

Propensity-score matched open aortic group. by Tomi Obafemi (12328433)

“…However, the incidence of post-op ventilator associated pneumonia (VAP) decreased from 5.0% to 2.1% (p = 0.003) and post-op urinary tract infections (UTIs) from 8.3% to 3.6% (p<0.001). …”

Pre-match CABG/Valve group. by Tomi Obafemi (12328433)

“…However, the incidence of post-op ventilator associated pneumonia (VAP) decreased from 5.0% to 2.1% (p = 0.003) and post-op urinary tract infections (UTIs) from 8.3% to 3.6% (p<0.001). …”

Propensity-score matched CABG/Valve group. by Tomi Obafemi (12328433)

“…However, the incidence of post-op ventilator associated pneumonia (VAP) decreased from 5.0% to 2.1% (p = 0.003) and post-op urinary tract infections (UTIs) from 8.3% to 3.6% (p<0.001). …”

Transcriptional and translational markers of syncytialization and biochemical differentiation are significantly decreased by rotenone. by O’Llenecia S. Walker (8486163)