Fitting relationship of E₅₀. by Junxia Zhou (14381598)

Fitting curve of E₅₀. by Junxia Zhou (14381598)

Pharmacological restoration of hypotension in mice with cardiac deficiency of <i>Prdm16</i>. by Ji-One Kang (844616)

Subjects:

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

DataSheet_1_Interventions to Decrease Carotid-Intima Media Thickness in Children and Adolescents With Type 1 Diabetes: A Systematic Review and Meta-Analysis.docx by Adina Mihaela Epure (9673974)

“…</p>Conclusions<p>Some pharmacological interventions may decrease CIMT in children with type 1 diabetes. However, there is great uncertainty with respect to their effects and no strong conclusions can be drawn. …”

Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer by Fan-Fan Shang (16953264)

“…Herein, we designed and synthesized 2-OH- and 16-OH-modified CuB derivatives to improve their antitumor efficacy and reduce toxicity. …”

Preliminary search for price decreases for the period 01 Jan. 2021–14 Jun. 2022. by Jevgeni Tarassov (13889285)

The synchronous activity of SGN fiber populations is disrupted and their response to sound is decreased with increasing levels of <i>L</i>_<i>u</i> heterogeneity. by Maral Budak (6680351)

Endogenously tagged DAF-16::mNeongreen and DAF-16::mKate2 localize to vesicles. by İçten Meraş (13184380)

Tissue, days post-infection (dpi) and the top 10 most significant genes with increased and decreased expression with valid gene symbols for the response contrasts. by Gillian P. McHugo (8965919)

Mean CBD concentration (%) for duration of vegetative phase (DVP) and inflorescence fraction. by Torsten Schober (20485754)

Interareal CFS and PAC decrease as a function of distance. by Felix Siebenhühner (383306)

VACV infection decreases the level of acetyl-CoA. by Anil Pant (10074299)

Toxoplasma infection leads to a decrease in the concentration of EVs. by Emily Z. Tabaie (16630841)

Fig 2 - by Yajie Hu (550783)

“…(B) Heat-map showing the increased (red) or decreased (green) expression trends of common differentially expressed genes during CV-A16 infection.…”

PAM16 correlation with N-MYC. by Zahra Motahari (6814013)

Example concentration fluctuation time series of natural plumes for two odorants emitted by a single source or two separate sources [16]. by Mario Pannunzi (553941)

The LCS stream is absent in E16.5 <i>Emx1</i>-cKO mice. by Sathish Venkataramanappa (10331993)

Projection of testing costs under different cost scenarios for medical supplies and personnel (USD). by Nelmo Jordão Manjate (16324619)

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