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mean decrease » a decrease (Expand Search)
ng decrease » nn decrease (Expand Search), _ decrease (Expand Search), a decrease (Expand Search)
we decrease » _ decrease (Expand Search), a decrease (Expand Search), nn decrease (Expand Search)
1 decrease » _ decrease (Expand Search), a decrease (Expand Search), _ decreased (Expand Search)
mean decrease » a decrease (Expand Search)
ng decrease » nn decrease (Expand Search), _ decrease (Expand Search), a decrease (Expand Search)
we decrease » _ decrease (Expand Search), a decrease (Expand Search), nn decrease (Expand Search)
1 decrease » _ decrease (Expand Search), a decrease (Expand Search), _ decreased (Expand Search)
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Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben...
Published 2021“…Starting from hit compound <b>1</b> and its co-crystal structure with MAGL, structure-based drug discovery (SBDD) approach enabled us to generate various spiro scaffolds like <b>2a</b> (azetidine-lactam), <b>2b</b> (cyclobutane-lactam), and <b>2d</b> (cyclobutane-carbamate) as novel bioisosteres of 3-oxo-3,4-dihydro-2<i>H</i>-benzo[<i>b</i>][1,4]oxazin-6-yl moiety in <b>1</b> with higher lipophilic ligand efficiency (LLE). …”
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Flow chart of the study procedures.
Published 2023“…<div><p>Introduction</p><p>Although the rapid plasma reagin (RPR) test is used to determine treatment efficacy for syphilis, animal studies show that it decreases gradually after an initial increase even without treatment. …”
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GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age.
Published 2021“…In whole brain homogenate (A,C) and liver homogenate (B,D), GCase activity is significantly decreased in the <i>GBA1</i> D409V KI homozygous (HOM) mice as compared to C57Bl/6 wild type (WT) mice (n = 7/group). …”
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Performance of selected antimalarials against field isolates during the study period.
Published 2024Subjects: -
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Performance of selected drugs against field isolates during the study period.
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Frequency of SNPs in <i>Pfmrp1</i> gene in field isolates during the study period.
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<i>In vitro</i> susceptibility responses of field isolates to antimalarials during the study period.
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