Showing 121 - 140 results of 42,417 for search '(( 50 ((((ng decrease) OR (we decrease))) OR (mean decrease)) ) OR ( 6 1 decrease ))', query time: 0.81s Refine Results
  1. 121
  2. 122
  3. 123
  4. 124

    Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben... by Shuhei Ikeda (2380180)

    Published 2021
    “…Starting from hit compound <b>1</b> and its co-crystal structure with MAGL, structure-based drug discovery (SBDD) approach enabled us to generate various spiro scaffolds like <b>2a</b> (azetidine-lactam), <b>2b</b> (cyclobutane-lactam), and <b>2d</b> (cyclobutane-carbamate) as novel bioisosteres of 3-oxo-3,4-dihydro-2<i>H</i>-benzo­[<i>b</i>]­[1,4]­oxazin-6-yl moiety in <b>1</b> with higher lipophilic ligand efficiency (LLE). …”
  5. 125

    Flow chart of the study procedures. by Kazuhiko Ikeuchi (9234268)

    Published 2023
    “…<div><p>Introduction</p><p>Although the rapid plasma reagin (RPR) test is used to determine treatment efficacy for syphilis, animal studies show that it decreases gradually after an initial increase even without treatment. …”
  6. 126
  7. 127

    GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age. by Nicole K. Polinski (10947787)

    Published 2021
    “…In whole brain homogenate (A,C) and liver homogenate (B,D), GCase activity is significantly decreased in the <i>GBA1</i> D409V KI homozygous (HOM) mice as compared to C57Bl/6 wild type (WT) mice (n = 7/group). …”
  8. 128
  9. 129
  10. 130
  11. 131
  12. 132
  13. 133
  14. 134
  15. 135
  16. 136
  17. 137
  18. 138
  19. 139
  20. 140