First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

Subjects:

Effects of metformin and/or sodium salicylate on TNFα-induced inflammation in mHypoE-46 neurons. by Wenqing Ye (3015147)

Decrease of 4 Asp isomers at 70°C. by Kenzo Aki (386666)

“…<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058515#pone-0058515-g007" target="_blank">Figure 7b:</a> decrease of L-β-Asp with incubation of T6-Lβ peptide at 70°C. …”

Increased lipid accumulation and decreased klotho expressions in palmitate-treated mouse podocytes. by Jeong Suk Kang (7359572)

“…Boxes are enlarged images of representative lipid droplets. magnification 20x; scale bar = 50 μm and 100 μm. (c) Western blot showing the decreased expression of klotho and nephrin proteins by palmitate treatment. …”

Tranilast decreases OC formation induced by RANKL. by Tien Van Phan (583324)

Microglia-conditioned medium decreases NPC viability. by Johanna Mäkelä (223358)

Cortactin knockdown results in decreased FA turnover. by Alok Tomar (139282)

H2-K^b overexpression decreases NSPC proliferation and impairs adult hippocampal neurogenesis. by Karin Lin (11037548)

Decrease in activity of transcriptional factor NRF2 in MCF-7 cells exposed to gDNA^OX at final concentrations of 50 ng/mL for 2 hours. by Svetlana V. Kostyuk (473354)

Injection of rIL-6 in IL-6KO mice decreased chronic disease severity following CB3/LPS treatment. by Maya C. Poffenberger (262165)

“…Magnification:400×. (B) Chronic cardiac disease histology was scored blindly by a four tier grading system to determine severity differences: grade 1, 0–10% pathology; grade 2, 11–25%; grade 3, 26–50%; grade 4, greater than 50% (black circles indicate wt mice with DMEM, white circles indicate IL-6KO mice with DMEM, grey circles indicate IL-6KO mice with rIL-6) (bar is mean±SE, *p<0.05). …”

Elevated Ang2 expression and decreased Ang1 expression during <i>O</i>. <i>tsutsugamushi</i> infection. by Brandon Trent (8520288)

HemaMax administration decreased leukopenia (a) and thrombocytopenia (b) at nadir in irradiated, unsupported rhesus monkeys. by Lena A. Basile (331369)

Incubation of <i>T</i>. <i>brucei</i> with Pol I transcription inhibitors results in a dramatic decrease in VEX1 foci. by Louise E. Kerry (3815164)

CMV infection decreases integrity of polarized HCoEpiC and increases barrier permeability. by Ekaterina Maidji (3797899)

Inability of macrophages to respond to IL-10 results in decreased persistence of <i>B. abortus in vivo</i>. by Mariana N. Xavier (133803)

Decreased dendritic spine density in the mature cortex of <i>Cln6^nclf</i> mice. by Jeremy P. Morgan (479017)

FTY720 decreased viability, proliferation, and motility and induced apoptosis in human hepatoblastoma cells. by Laura L. Stafman (6577184)

“…(B) Following 24 hours of treatment with FTY720, the proliferation of HuH6 cells measured using the CellTiter 96 cell proliferation assay was significantly decreased (IC₅₀ = 6.4 μM, p ≤ 0.05). …”

Baseline level biochemical and circulating biomarkers in study subjects. by Jaskiran Kaur (160829)

Change in serum levels of vitamin D and angiogenic marker at 16 weeks follow-up. by Jaskiran Kaur (160829)

Propofol induced cell death and decreased mitochondrial membrane potential in a concentration- and time-dependent manner. by Chisato Sumi (3521705)