Inhibition of the mitochondrial fission decreases mtROS production. by Dong Ma (584680)

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

Loss of exostosin-1 (EXT1), specific reduction of heparan sulfate (HS) in fibroblasts, and decreased acidic mucosubstances in the stroma of <i>S100a4-Cre; Ext1</i><sup><i>f/f</i></... by Ayumi Niwa (6256790)

FoxO3a-dependent mechanism of miR-150-5p in regulating pyroptosis in ox-LDL-stimulated RAW264.7 macrophages. (A-E) FoxO3a and ARC expression analyzed by (A-C) RT-qPCR and (D-E) Wes... by Ping-yu Cai (12389929)

The raw data of ¹³⁷Cs activity concentrations in <i>Aralia elata</i> buds and environmental variables analyzed in Sakai et al. Exploring simple ways to avoid collecting... by Masaru Sakai (1669627)

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¹³⁷Cs activity concentrations in <i>Aralia elata</i> buds collected in Iitate village, Fukushima from 2014 to 2022. by Masaru Sakai (1669627)

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Relationship between the ¹³⁷Cs inventory in the soil and the dose rate on the soil surface. by Masaru Sakai (1669627)

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Results of the linear mixed model used to test for effects of the dose rate at the soil surface, organic soil layer thickness, and slope steepness on the ¹³⁷Cs activity... by Masaru Sakai (1669627)

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Fig 2 - by Masaru Sakai (1669627)

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Fig 3 - by Masaru Sakai (1669627)

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Flow chart of the study procedures. by Kazuhiko Ikeuchi (9234268)

“…Pre-treatment spontaneous decrease of RPR titer was associated with a slower decrease in post-treatment RPR titer.…”

Experimental validation revealed that ACADSB and ACADM decreased in patients with UC. by Hongliang Chen (538815)

Data_Sheet_1_Where Might We Find Ecologically Intact Communities?.docx by Andrew J. Plumptre (8140635)

Mylipb decreases tbk1-mediated irf3 phosphorylation. by Zhi Li (72309)

Loss of FOXP1 results in decreased number of bRGCs. by Seon Hye E. Park (16765033)

MVEC viability is decreased over time in PEG-based hydrogels. by Rebecca A. Scott (488956)

The effects of NAC on the decreased number of myotube formations caused by arecoline. by Yi-Xuan Li (6633845)

Rspo3 decreases c-fos IF intensity in rRPa. by Kenji Uno (548200)

Upregulation of astroglial Cx30 decreased LTP and recognition memory. by Eléonore Hardy (15208385)

“…<b>(b</b>) Tetanus-induced PTP curves (arrow, two 100 Hz tetani for 1 s, interval 20 s and representative traces under CPP (20 μM). …”