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ng decrease » _ decrease (Expand Search), a decrease (Expand Search), gy decreased (Expand Search)
we decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
nn decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
1 decrease » _ decrease (Expand Search), a decrease (Expand Search), _ decreased (Expand Search)
16 1 » 16 _ (Expand Search), 1 1 (Expand Search), 6 1 (Expand Search)
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LGI1 Abs decrease the expression of AMPA-R inside clusters at the surface of excitatory neurons in the hippocampus.
Published 2022“…The total density of surface GluA1 subunits decreased after LGI1 P1 IgG infusion compared to control C1 IgG infusion in GAD- area in the DG of the hippocampus (Unpaired t test *p = 0.031, n<sub>Ctrl =</sub> 16 area, n<sub>LGI1</sub> = 13 area) (B) but not in CA3 region (Mann-Whitney test p = 0.33, n<sub>Ctrl =</sub> 19 area, n<sub>LGI1</sub> = 9 area) (C) nor CA1 (Unpaired t-test p = 0.49, n<sub>Ctrl =</sub> 11 area, n<sub>LGI1</sub> = 14 area) (D). …”
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Fructose-1,6-bisphosphate prevents pulmonary fibrosis by regulating extracellular matrix deposition and inducing phenotype reversal of lung myofibroblasts
Published 2019“…<div><p>Pulmonary fibrosis (PF) is the result of chronic injury where fibroblasts become activated and secrete large amounts of extracellular matrix (ECM), leading to impaired fibroblasts degradation followed by stiffness and loss of lung function. Fructose-1,6-bisphosphate (FBP), an intermediate of glycolytic pathway, decreases PF development, but the underlying mechanism is unknown. …”
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Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer
Published 2023“…Derivative <b>A11</b> directly binds to the insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) protein with a <i>K</i><sub>D</sub> value of 2.88 nM, which is about 23-fold more potent than CuB, leading to the decreased expression of downstream apoptosis- and cell cycle-related proteins. …”