Pharmacological restoration of hypotension in mice with cardiac deficiency of <i>Prdm16</i>. by Ji-One Kang (844616)

Subjects:

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer by Fan-Fan Shang (16953264)

“…Herein, we designed and synthesized 2-OH- and 16-OH-modified CuB derivatives to improve their antitumor efficacy and reduce toxicity. …”

Preliminary search for price decreases for the period 01 Jan. 2021–14 Jun. 2022. by Jevgeni Tarassov (13889285)

Baseline level biochemical and circulating biomarkers in study subjects. by Jaskiran Kaur (160829)

Change in serum levels of vitamin D and angiogenic marker at 16 weeks follow-up. by Jaskiran Kaur (160829)

Endogenously tagged DAF-16::mNeongreen and DAF-16::mKate2 localize to vesicles. by İçten Meraş (13184380)

Tissue, days post-infection (dpi) and the top 10 most significant genes with increased and decreased expression with valid gene symbols for the response contrasts. by Gillian P. McHugo (8965919)

Interareal CFS and PAC decrease as a function of distance. by Felix Siebenhühner (383306)

VACV infection decreases the level of acetyl-CoA. by Anil Pant (10074299)

Toxoplasma infection leads to a decrease in the concentration of EVs. by Emily Z. Tabaie (16630841)

Fig 2 - by Yajie Hu (550783)

“…(B) Heat-map showing the increased (red) or decreased (green) expression trends of common differentially expressed genes during CV-A16 infection.…”

PAM16 correlation with N-MYC. by Zahra Motahari (6814013)

Example concentration fluctuation time series of natural plumes for two odorants emitted by a single source or two separate sources [16]. by Mario Pannunzi (553941)

The LCS stream is absent in E16.5 <i>Emx1</i>-cKO mice. by Sathish Venkataramanappa (10331993)

Data_Sheet_1_Marathon Running Increases Synthesis and Decreases Catabolism of Joint Cartilage Type II Collagen Accompanied by High-Energy Demands and an Inflamatory Reaction.PDF by José A. Hernández-Hermoso (11545663)

“…Mean sC2C levels (220.83 ± 39.50 ng/ml) decreased post-race (188.67 ± 38.52 ng/ml) (p = 0.002). …”

Fitting curve of rock E₅₀. by Junxia Zhou (14381598)

Inclusion and exclusion criteria for systematic review [16]. by Gail M. Thornton (12378588)

Observed and 16s rRNA standardized log₁₀ <i>invA</i> gene copies per gram feces per qPCR reaction. by Naomi Ohta (735090)