Table 1_A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity.xls by Wen Wang (6570)

STAT6-driven immunity decreases <i>N</i>. <i>brasiliensis</i> reproductive output and survival within host. by Annabel A. Ferguson (17616286)

Discovery of Novel Pyrimidine-Based Capsid Assembly Modulators as Potent Anti-HBV Agents by WooChan Kim (10690503)

“…One of the synthesized derivatives, compound <b>23h</b> (R¹ = MeSO₂, R² = 1-piperidin-4-amine, R³ = 3-Cl-4-F-aniline) displayed potent inhibitory effects in the in vitro assays (52% inhibition in the protein-based assay at 100 nM and an IC₅₀ value of 181 nM in the serum HBV DNA quantification assay). …”

Longer polyQ sequences decrease the nuclear localization of AR in the absence of hormone. by Carlos M. Roggero (11909585)

Binding of C4BP decreases the association of CEACAM-binding Opa+ <i>N</i>. <i>gonorrhoeae</i> with neutrophils. by Lacie M. Werner (14710419)

Correlation of CAD and CSI to KC grade (N: normal). by Sunny Kwok (13124155)

Vital signs and shock indices between survivors and non-survivors stratified by LVEF (n = 392). by Kyu Jin Lee (18143946)

Discovery of <i>N</i>‑(1,3,4-Thiadiazol-2-yl)amide Derivatives as Uncompetitive Inhibitors of 6‑Phosphogluconate Dehydrogenase by Rong Zhang (44942)

“…Among them, <b>19n</b> exhibited significant potency against 6PGD with an IC₅₀ value of 5.1 ± 1.0 μM. …”

Example of the process used to determine time dependence of <i>ε</i>_max and IC₅₀. by Hope Murphy (8843516)

Partial correlation of <i>ε</i>_max (left column) and IC₅₀ (right column) estimates at 10 days and 20 days (first and second bar of each color, respectively) o... by Hope Murphy (8843516)

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). Instead, only a subtle shift in the location of this water molecule resulted in a dramatic decrease in the energy of this high-energy hydration site, as shown by the WaterMap analysis combined with microsecond timescale molecular dynamics simulations. …”

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). Instead, only a subtle shift in the location of this water molecule resulted in a dramatic decrease in the energy of this high-energy hydration site, as shown by the WaterMap analysis combined with microsecond timescale molecular dynamics simulations. …”

DataSheet_1_IL-40: A New B Cell-Associated Cytokine Up-Regulated in Rheumatoid Arthritis Decreases Following the Rituximab Therapy and Correlates With Disease Activity, Autoantibod... by Adela Navrátilová (11589532)

“…IL-40 was analysed in the serum/synovial fluid of patients with RA (n=50), systemic lupus erythematosus (SLE, n=69), OA (n=44), and healthy controls (HC, n=50). …”

Characteristics of non-septic (qSOFA = 0) and septic (qSOFA≥1) emergency unit patients with suspected infections (N = 17,490). by Brian Rice (4393609)

Image_1_Comparison Of The Gut Microbiota In Different Age Groups In China.tif by Hang Yan (2792143)

“…Our study divided the subjects (n=614) into two groups by using 50 years as the age cut-off point for the grouping. …”

Table_1_Comparison Of The Gut Microbiota In Different Age Groups In China.xlsx by Hang Yan (2792143)

“…Our study divided the subjects (n=614) into two groups by using 50 years as the age cut-off point for the grouping. …”

Mother-calf pairs differences among epidermis layers normalized to the mean of all three layers for δ¹³C and δ¹⁵N values. by Michelle Gelippi (9580022)

Characteristics of the participants in the E24 study (N = 901). by Phaik Ling Quah (5759120)

Net work vs phase of activation and lattice spacing. Top) We simulated work loops in the half sarcomere model at phases of activation of 0 to 0.95 in 0.05 increments, as well as over lattice spacings from 12 to 18 nm and plotted the new work for each condition. Bottom) We then simulated work loops over the same range, but with the stiffness of either the linear or torsional spring comprising the crossbridge head increased or decreased by 50% separately.... by Travis Carver Tune (21012349)

“…Bottom) We then simulated work loops over the same range, but with the stiffness of either the linear or torsional spring comprising the crossbridge head increased or decreased by 50% separately. …”

Examples of participants’ prosocial behaviour described during focus groups (n = 42). by Katie J. Shillington (16557695)