DataSheet4_Lethal activity of BRD4 PROTAC degrader QCA570 against bladder cancer cells.ZIP by Qiang Wang (32383)

“…QCA570 potently induces degradation of BRD4 protein at nanomolar concentrations, with a DC₅₀ of ∼ 1 nM. It decreases EZH2 and c-MYC levels by transcriptional suppression and protein degradation. …”

DataSheet9_Lethal activity of BRD4 PROTAC degrader QCA570 against bladder cancer cells.ZIP by Qiang Wang (32383)

“…QCA570 potently induces degradation of BRD4 protein at nanomolar concentrations, with a DC₅₀ of ∼ 1 nM. It decreases EZH2 and c-MYC levels by transcriptional suppression and protein degradation. …”

DataSheet8_Lethal activity of BRD4 PROTAC degrader QCA570 against bladder cancer cells.ZIP by Qiang Wang (32383)

“…QCA570 potently induces degradation of BRD4 protein at nanomolar concentrations, with a DC₅₀ of ∼ 1 nM. It decreases EZH2 and c-MYC levels by transcriptional suppression and protein degradation. …”

DataSheet2_Lethal activity of BRD4 PROTAC degrader QCA570 against bladder cancer cells.ZIP by Qiang Wang (32383)

“…QCA570 potently induces degradation of BRD4 protein at nanomolar concentrations, with a DC₅₀ of ∼ 1 nM. It decreases EZH2 and c-MYC levels by transcriptional suppression and protein degradation. …”

DataSheet11_Lethal activity of BRD4 PROTAC degrader QCA570 against bladder cancer cells.ZIP by Qiang Wang (32383)

“…QCA570 potently induces degradation of BRD4 protein at nanomolar concentrations, with a DC₅₀ of ∼ 1 nM. It decreases EZH2 and c-MYC levels by transcriptional suppression and protein degradation. …”

DataSheet3_Lethal activity of BRD4 PROTAC degrader QCA570 against bladder cancer cells.ZIP by Qiang Wang (32383)

“…QCA570 potently induces degradation of BRD4 protein at nanomolar concentrations, with a DC₅₀ of ∼ 1 nM. It decreases EZH2 and c-MYC levels by transcriptional suppression and protein degradation. …”

Direct Unequal Cleavages: Embryo Developmental Competence, Genetic Constitution and Clinical Outcome by Qiansheng Zhan (3374120)

Image4_Formononetin isolated from Sophorae flavescentis inhibits B cell-IgE production by regulating ER-stress transcription factor XBP-1.tif by Nan Yang (305078)

“…Formononetin significantly and dose dependently decreased the IgE production in U266 cells across a concentration range of 2–20 µg/ml (p < 0.05–0.001 vs. untreated cells) with an IC50 value of 3.43 μg/ml. …”

Image5_Formononetin isolated from Sophorae flavescentis inhibits B cell-IgE production by regulating ER-stress transcription factor XBP-1.tif by Nan Yang (305078)

“…Formononetin significantly and dose dependently decreased the IgE production in U266 cells across a concentration range of 2–20 µg/ml (p < 0.05–0.001 vs. untreated cells) with an IC50 value of 3.43 μg/ml. …”

Image1_Formononetin isolated from Sophorae flavescentis inhibits B cell-IgE production by regulating ER-stress transcription factor XBP-1.tif by Nan Yang (305078)

“…Formononetin significantly and dose dependently decreased the IgE production in U266 cells across a concentration range of 2–20 µg/ml (p < 0.05–0.001 vs. untreated cells) with an IC50 value of 3.43 μg/ml. …”

Image2_Formononetin isolated from Sophorae flavescentis inhibits B cell-IgE production by regulating ER-stress transcription factor XBP-1.tif by Nan Yang (305078)

“…Formononetin significantly and dose dependently decreased the IgE production in U266 cells across a concentration range of 2–20 µg/ml (p < 0.05–0.001 vs. untreated cells) with an IC50 value of 3.43 μg/ml. …”

Image3_Formononetin isolated from Sophorae flavescentis inhibits B cell-IgE production by regulating ER-stress transcription factor XBP-1.tif by Nan Yang (305078)

“…Formononetin significantly and dose dependently decreased the IgE production in U266 cells across a concentration range of 2–20 µg/ml (p < 0.05–0.001 vs. untreated cells) with an IC50 value of 3.43 μg/ml. …”

Serum brain-derived neurotrophic factor reflects the lower inflammation, lipid level, and major adverse cardiac and cerebrovascular events risk in maintenance hemodialysis patients by Hui Du (639270)

“…BDNF negatively correlated with diabetes history, hemodialysis duration, C-reactive protein, total cholesterol, and low-density lipoprotein cholesterol in MHD patients. During a median follow-up period of 17.4 months, accumulating MACCE rate was calculated, which disclosed that high BDNF was correlated with decreased accumulating MACCE rate in MHD patients. …”

Deoxygenation of pyrolysis vapour derived from durian shell using catalysts prepared from industrial wastes rich in Ca, Fe, Si and Al by Tan, Y.L.

“…Catalytic fast pyrolysis of durian shell using waste-derived catalysts is an effective waste management strategy as the bio-oil produced can be a potential alternative source of energy or chemical feedstocks.…”
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DataSheet_1_Metabolomic and transcriptomic exploration of the uric acid-reducing flavonoids biosynthetic pathways in the fruit of Actinidia arguta Sieb. Zucc..docx by Yubo Wang (556762)

“…Zucc., a major cultivar in northern China, provides valuable information for the development of food and drug homologous functional foods.…”

Vegetation changes in Jasper National Park assessed from resampling of ecological land classification plots established in the 1970s by Kevin P. Timoney (2200432)

“…<p>Canada’s mountain ecosystems are changing as a result of climate change and a host of natural and anthropogenic disturbances. …”

Comparison of the SNF1 pathway mutants with regard to colony morphology and conidial development. by Xiao-Qing Zeng (103514)

“…<i>ΔMosak1ΔMotos3</i> exhibited a decreased mycelial growth rate, while no significant difference in the colony size was observed between other mutants and Guy11. …”

Changes in the dry mass of glue solution. by Yaqin Qian (19507733)

“…The results indicated that preparing FG following the optimal processes of the new glue-making technique not only ensured the quality of the glue solution but also outperformed the traditional handicraft technique in the following aspects: 1) it simplifies the production process, reduces labor intensity, and saves time: the soaking time is decreased by 50% and the traditional manual smashing process is not required; 2) it improves the glue yield by 5.42%; and 3) due to introduction of mechanical processing, time and temperature are controllable, rendering production more repeatable and easily up-scaled.…”

Contour plot of 〈<i>N</i>〉/<i>K</i> in dependency on <i>b</i>₀ and the turnover <i>θ</i>. by Natalie Tkachenko (3937883)

“…Here, color legends are given for <i>K</i> = 10, <i>K</i> = 50, <i>K</i> = 100. The dashed black arrow shows how 〈<i>N</i>〉/<i>K</i> changes when the time step decreases and <i>θ</i>/<i>b</i>₀ = 0.6/0.8. …”

<i>Alms1^{L2131X/L2131X}</i> Mice Recapitulate Human Alström Syndrome by Guochun Li (273973)

“…<div><p>(A) <i>Alms1^{L2131X/L2131X}</i> mice gain more fat mass than heterozygote or wild-type controls but equivalent lean mass.…”