Oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function by Enxu Bi (5994113)

“…Oridonin also remarkably enhanced the anti-tumor effect of cisplatin on SNU-216 cells, as it significantly increased apoptotic cells and decreased cell viability. Moreover, the mRNA and protein expression of p53 was significantly up-regulated in oridonin-treated cells, while Mdm2 expression was down-regulated. …”

Data Sheet 1_Robotic hormonal and autonomic modulation for type 2 diabetes: ileal interposition and hepatic sympathectomy.pdf by Alcides Jose Branco Filho (22809092)

“…The manuscript is intended to spark discussion around future surgical strategies based on two proof-of-concept index cases.</p>Methods<p>We present two patients with poorly controlled T2DM. …”

Type 2 diabetes mellitus alters cardiac mitochondrial content and function in a non-obese mice model by AINHOA R. DE YURRE (10363602)

“…Thus, we test the hypothesis that a combination of a high fat diet (HFD) and low doses of streptozotocin (STZ) recapitulate a suitable mice model of T2DM to study the cardiac mitochondrial disturbances induced by this disease. …”

Effect of a coordinated reduction in multiple enzymes on sterol biosynthesis. by Mathieu Blanc (139647)

“…Intensity values relative to β-actin calculated by densitometry show a decrease of the total amount of protein in the mCMV-infected BMDM compared to the mock-treated samples of 64% for HMGCS1, 50% for HMGCR, and 85% for SQLE. …”

Table 1_Evaluation of clopidogrel responsiveness using the Platelet Function Analyzer-200 (PFA-200) in dogs.docx by Joon-Ho Shin (2161726)

“…<p>We aimed to evaluate the prevalence of clopidogrel resistance in hypercoagulable dogs using the Platelet Function Analyzer-200 (PFA-200) P2Y cartridge; further, we aimed to assess the utility of hematocrit (HCT), platelet count (PLT), prothrombin time (PT), activated partial thromboplastin time (aPTT), thromboelastography (TEG) parameters, and D-dimer level as indicators of clopidogrel efficacy. …”

Numerically simulated GRAPPA-accelerated acquisitions of a phantom. by Andrew J. Coristine (3219420)

“…<p>Random coil noise was added to the 50 scan average described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0163618#pone.0163618.g001" target="_blank">Fig 1C</a>) for the conventional T₂-Prep as well as for 2D-T₂-Prep modules of radius 6.0 and 12.0 cm. …”

Datasheet1_TRIM8 as a predictor for prognosis in childhood acute lymphoblastic leukemia based on a signature of neutrophil extracellular traps.docx by Waihin Tin (19440019)

“…Correlation analysis revealed significant associations with B cells, NK cells, mast cells, T cells, plasma cells, dendritic cells, and monocytes. The IC₅₀ values of drugs such as all-trans-retinoic acid (ATRA), axitinib, doxorubicin, methotrexate, sorafenib, and vinblastine were increased, while dasatinib exhibited a lower IC₅₀. …”

Table1_TRIM8 as a predictor for prognosis in childhood acute lymphoblastic leukemia based on a signature of neutrophil extracellular traps.xlsx by Waihin Tin (19440019)

“…Correlation analysis revealed significant associations with B cells, NK cells, mast cells, T cells, plasma cells, dendritic cells, and monocytes. The IC₅₀ values of drugs such as all-trans-retinoic acid (ATRA), axitinib, doxorubicin, methotrexate, sorafenib, and vinblastine were increased, while dasatinib exhibited a lower IC₅₀. …”

LR coefficients obtained from the biochemistry data. by Vladimir Naumov (8582277)

“…To generate compatible coefficient values for parameters with different ranges (e.g. lymphocyte count typically ranges from 0 to 3 while CRP ranges from 0 to 200) we normalized the data using the l2 normalization.…”

Image_2_Integral Projection Models and Sustainable Forest Management of Agave inaequidens in Western Mexico.tif by Ignacio Torres-García (4579165)

“…Our study was performed in four well-conserved wild populations in Central Western Mexico, each population was sampled in a plot of about one hectare composed by 10 subplots 50 x 5 m (2500 m²). …”

Role of Organic Counterion in Lead- and Tin-Based Two-Dimensional Semiconducting Iodide Perovskites and Application in Planar Solar Cells by Lingling Mao (513927)

“…Here, we report two series of new 2D halide perovskite solid solutions: (HA)­Pb_1–<i>x</i>Sn_<i>x</i>I₄ and (BZA)₂Pb_1–<i>x</i>Sn_<i>x</i>I₄ (<i>x</i> = 1, 0.75, 0.5, 0.25, 0), where HA stands for the organic spacer histammonium and BZA stands for benzylammonium cations. …”

Variable Responses of Benthic Communities to Anomalously Warm Sea Temperatures on a High-Latitude Coral Reef by Tom C. L. Bridge (448485)

“…Consequently, the longer-term effects of thermal anomalies on high-latitude reefs are difficult to predict. Here, we use an autonomous underwater vehicle to conduct repeated surveys of three 625 m² plots on a coral-dominated high-latitude reef in the Houtman Abrolhos Islands, Western Australia, over a four-year period spanning a large-magnitude thermal anomaly. …”

Intrinsic Up-Regulation of 2-AG Favors an Area Specific Neuronal Survival in Different In Vitro Models of Neuronal Damage by Sonja Kallendrusch (109796)

“…After PPT diacylglycerol lipase alpha (DAGL) protein, the synthesizing enzyme of 2-AG was decreased when <em>Dagl</em> mRNA expression and 2-AG levels were enhanced. …”

Supplementary Material for: The Effect of Blood Glucose and pCO₂ on Spectral EEG of Premature Infants during the First Three Days of Life by Schumacher E.M. (4136677)

“…<b><i>Background:</i></b> Spectral EEG analysis using automated quantification of total absolute band power (tABP) expresses brain function. We hypothesized that pCO₂ or blood glucose affects tABP during the critical first days of life in premature infants. …”

R″→T transition for a single subunit of GroEL. by Zheng Yang (264955)

“…The end states refer to subunit A in the PDB structures 1GRU and 1GR5. Results are shown for <i>F_min</i> = 0.4, 0.5, 0.6 and 0.7, corresponding to the allowable angular deviations of up to 50.8°, 45.0°, 39.2° and 33.2°, respectively, between and <i>v</i><i>_A</i>^(<i>k</i>) (or <i>v</i><i>_B</i>^(<i>k</i>)). …”

Table_2_Plant Colonization of Green Roofs Is Affected by Composition of Established Native Plant Communities.docx by Jason M. Aloisio (6238937)

“…To address this knowledge gap, we studied colonization dynamics of 10 green roofs in New York City (NY, United States), each established at the same time with the same source materials. …”

Table_1_Clinical and immunological features of an APLAID patient caused by a novel mutation in PLCG2.xls by Qi Peng (702503)

“…Background<p>The APLAID syndrome is a rare primary immunodeficiency caused by gain-of-function mutations in the PLCG2 gene. We present a 7-year-old APLAID patient who has recurrent blistering skin lesions, skin infections in the perineum, a rectal perineal fistula, and inflammatory bowel disease.…”

Splicing assays of wt and mutant pre-mRNA in the absence and presence of wild-type StpA and mutant G126V-StpA by Rupert Grossberger (9105)

“…The reactions were performed in the presence of 5 mM MgCl, 0.5 mM GTP, 50 mM Tris–HCl (pH 7.3) and 0.4 mM spermidine (see Materials and Methods). () Splicing of the wt intron pre-RNA without added protein (full circles), with the addition of 1.4 μM wild-type StpA (full squares) or 1.4 μM G126V-StpA mutant (empty squares). () Splicing of the C865U pre-RNA intron mutant without protein (full circles), with addition of 1.4 μM wild-type StpA (full squares) or 1.4 μM G126V-StpA mutant (empty squares). …”

Table_2_Radiation Induced Metabolic Alterations Associate With Tumor Aggressiveness and Poor Outcome in Glioblastoma.XLSX by Kshama Gupta (8799284)

“…To assess longevity of radiation effects, we compared survival with implantation occurring 2 months vs. 24 hrs following radiation, finding worse survival in animals implanted at 2 months. …”

Prenatal Air Pollution Exposure and Early Cardiovascular Phenotypes in Young Adults by Carrie V. Breton (74382)

“…For example, a 2 SD increase in prenatal PM_2.5 was associated with CAS indices, including a 5% increase (β = 1.05, 95% CI 1.00–1.10) in carotid stiffness index beta, a 5% increase (β = 1.05, 95% CI 1.01–1.10) in Young’s elastic modulus and a 5% decrease (β = 0.95, 95% CI 0.91–0.99) in distensibility. …”