Aquaporin 2 Mutations in <i>Trypanosoma brucei gambiense</i> Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol by Fabrice E. Graf (469055)

“…Here we describe two different kinds of <i>TbAQP2</i> mutations found in <i>T. b. gambiense</i> field isolates: simple loss of <i>TbAQP2</i>, or loss of wild-type <i>TbAQP2</i> allele combined with the formation of a novel type of <i>TbAQP2/3</i> chimera. The identified mutant <i>T. b. gambiense</i> are 40- to 50-fold less sensitive to pentamidine and 3- to 5-times less sensitive to melarsoprol than the reference isolates. …”

TBC-2 is required for full lifespan extension and increased fat storage resulting from decreased insulin/IGF signaling. by İçten Meraş (13184380)

Adaptation to cool temperature decreases basal and stimulated lipolysis and increases <i>de novo</i> lipogenesis and TAG synthesis. by Hiroyuki Mori (512656)

“…<p>(<b>A, B</b>) Adipocytes were treated with 10 μM forskolin or 2 μM CL-316,243 (CL) for 6 hours and secretion of glycerol (<b>A</b>) and NEFA (<b>B</b>) measured (<i>n</i> = 4). …”

Nemp1 KO mice display splenomegaly, blood defects, and erythroid lineage expansion. by Didier Hodzic (132944)

The RsW50 of regulatory spleen cells is decreased by enriching for CD8⁺ regulatory spleen cells. by Roshanak Sharafieh (311047)

Decreased expression of SOCS1 protein and mRNA in SLE and its relation to Jak1 and STAT2 phosphorylation. by Gabriela Ramírez-Vélez (146925)

Inhibition of GLS1 decreases the proportion of CCR6 and CXCR3 expressing CD4⁺ T cells. by Zeynep Sener (3146064)

“…(B–C) The proportion of CCR6 expressing cells at day 3 (left) and day 5 (right) under normoxia (black bars) and hypoxia (grey bars) in the presence (+) and absence (-) of 25 μM BPTES and 50 μM 968. BPTES and 968 significantly decrease the proportion of CCR6 expressing cells under normoxia both at day 3 and 5, whereas 968 but not BPTES decrease the proportion of CCR6 expressing cells under hypoxia both at day 3 and 5. …”

THRα/β EC₅₀ values and selectivity of test compounds. by Xuan G. Luong (9761423)

Panobinostat downregulated Ron mRNA, protein expression and decreased downstream signaling through pAkt, XIAP, and survivin. by Yi Zou (439002)

PDK1 inhibitor PF-5177624 decreased IGF-I induced AKT and p70S6K phosphorylation. by Sangita M. Baxi (123560)

Downregulation of G9a induces autophagy and decreases tumorigenicity in neuroblastoma cells. by Xiao-Xue Ke (626989)

NS affects lipid transport in ApoE^-/-mouse models. by Yihua Wang (491766)

SARS-CoV-2 induced lung inflammation is increased with IL-10 blockade and decreased with IFNγ blockade. by Christine E. Nelson (18946410)

CovR levels are decreased in the CovR-T65A strain. by Nicola Horstmann (201711)

CFD-DEM Coupling Simulation and Cross-Scale Correlation Analysis of a Liquid-Containing Gas–Solid Spouted Fluidized Bed Reactor by Delong Feng (9075738)

“…When μ > 50 mPa·s, the reverse applies. The macroscale study demonstrates that growing liquid content and viscosity causes a reduction in the bed expansion ratio and the bubble phase volume. …”

No protection against influenza infection in mice immunized with the double restricted epitopes. by Sara Ram Pedersen (843509)

Summary of the effect of MPDD on SDLP across all participants, and also participants categorized by driving styles (“NS” (no significant), “+” (significant increase), and “-” (sign... by Mobina Faqani (22783963)

Ustekinumab trough concentration are shown by responder status and anti-ustekinumab antibody (A) Patients with negative anti-ustekinumab antibody had significantly higher drug trou... by Hsien-Yi Chiu (799936)

General procedure for the synthesis of B. by Xueqin lu (22250795)

DataSheet1_A Non-Synonymous Point Mutation in a WD-40 Domain Repeat of EML5 Leads to Decreased Bovine Sperm Quality and Fertility.docx by Eriklis Nogueira (7475576)