Fitting curves of E₅₀. by Junxia Zhou (14381598)

E₅₀ fluctuation coefficient. by Junxia Zhou (14381598)

Fitting relationship of E₅₀. by Junxia Zhou (14381598)

Fitting curve of E₅₀. by Junxia Zhou (14381598)

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

RNS60 treatment decreased Aß aggregation and neurodegeneration in the stratum pyramidale in the CA3 region of the hippocampus of tMCAo animals 14 days after stroke. by Gloria Patricia Baena-Caldas (17721328)

The synchronous activity of SGN fiber populations is disrupted and their response to sound is decreased with increasing levels of <i>L</i>_<i>u</i> heterogeneity. by Maral Budak (6680351)

Preliminary search for price decreases for the period 01 Jan. 2021–14 Jun. 2022. by Jevgeni Tarassov (13889285)

Loss of <i>SLC4A11</i> expression in hCEnC leads to decreased cell barrier function. by Doug D. Chung (3611387)

VACV infection decreases the level of acetyl-CoA. by Anil Pant (10074299)

Screening of AJ01 T3SS Inhibitors. by Fa Dai (15810913)

Potato gene ontology enrichment results significant at <i>p</i> < 0.01. by Margaret A. Carpenter (6104180)

Longer polyQ sequences decrease the nuclear localization of AR in the absence of hormone. by Carlos M. Roggero (11909585)

Decreased IL-17 and increased IFN-γ producing cells in the gut of Rh-α₄β₇-VRC01-treated macaques. by Giulia Calenda (635216)

<i>Il-17c</i> deletion decreases the expression of inflammatory cytokines. by Giovanna Vella (6413774)

For the identification of effectors targeting AjTmod from AJ01, a pull-down assay was performed with recombinant GSTTmod (GST-fused complete AjTmod) as the bait and AJ01 total prot... by Fa Dai (15810913)

Fitting curve of rock E₅₀. by Junxia Zhou (14381598)

Alpha-smooth muscle actin (ASMA) is decreased while vimentin is increased in non-dilated bicuspid aortic valve (BAV)-associated aortas. by Brittany Balint (6829967)

Univariable and multivariable analyses (age- and abstinence days-adjusted), concerning a selection of medicaments with n ≥ 10 medicament users and p < 0.1 by univariate analysis.... by P.G.J. ter Horst (21743830)