يعرض 121 - 140 نتائج من 14,913 نتيجة بحث عن '(( 50 ((((ns decrease) OR (we decrease))) OR (nn decrease)) ) OR ( 25 c decrease ))', وقت الاستعلام: 0.54s تنقيح النتائج
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    Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant حسب Ittipat Meewan (7455041)

    منشور في 2019
    "…Several drugs targeting the protease have been developed, but drug-resistant mutant strains emerged. Here, we screened a library and synthesized a novel class of small molecules based on a tryptophan derivative scaffold identified as HCV NS3/4A protease inhibitors that are active against both wild type and mutant form of the protease. …"
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    Image_1_Receptor Interaction Profiles of 4-Alkoxy-Substituted 2,5-Dimethoxyphenethylamines and Related Amphetamines.tiff حسب Karolina E. Kolaczynska (8057336)

    منشور في 2019
    "…Structurally related 4-alkyloxy-substituted 2,5-dimethoxyamphetamines and phenethylamine congeners (2C-O derivatives) have been described but their pharmacology is mostly undefined. …"
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    Image_2_SIRT1 haplo-insufficiency results in reduced cortical bone thickness, increased porosity and decreased estrogen receptor alpha in bone in adult 129/Sv female mice.tif حسب Hanna Artsi (777390)

    منشور في 2022
    "…</p>Discussion<p>These findings demonstrate that 50% reduction in SIRT1 is sufficient to induce the hallmarks of skeletal aging namely, decreased cortical thickness and increased porosity in female mice, highlighting the role of SIRT1 as a regulator of cortical bone quantity and quality. …"
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    DAF-16/FOXO is Required for Locomotory Healthspan and Lifespan Benefits of Genetic Glycolysis Disruption. حسب Brian Onken (86790)

    منشور في 2020
    "…Data are pooled averages from 5 independent trials, n = 50 animals per condition per trial. Error bars represent SEM. *** <i>P</i> < 0.001; **** <i>P</i> < 0.0001; n.s. = not significant; all by one way ANOVA with Dunnett’s multiple comparisons test. …"
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