Simvastatin decreases cerebral vasospasm of the middle cerebral artery and reduces microthromboemboli after SAH. by Mohammed Sabri (355717)

“…Scale bar is 100 µm. <b>D</b> and <b>E</b>. Both pre-SAH and post-SAH treatment with simvastatin significantly decrease microthromboemboli in both cerebral cortex (<i>P</i><0.001) and hippocampus (<i>P</i><0.01) as compared to vehicle treated group. …”

Figure 1 Exogenous serotonin inhibits the Dar phenotype and decreases pathogen clearance rates by Rachel Mcmullan (506214)

“…Treatment with 3.8mg/ml 5-HT caused a 35% decrease in the number of Dar animals following M. nematophilum infection using standard assay conditions (small lawn) (A). …”

Nasal mucociliary clearance was decreased in <i>Ttll1</i>^−/− mice. by Toshiyuki Iwata (419270)

“…<p>(A) Tosufloxacin (50 mg/kg) was administered to <i>Ttll1</i>^−/− mice with rhinosinusitis to inhibit cough for 7 days. …”

Behavioral response to ambiguous conditioned fear cues is decreased in adult neurogenesis-deficient mice. by Lucas R. Glover (3912628)

RIG-I deficient mice demonstrate decreased protection against heterologous IAV challenge. by Matheswaran Kandasamy (105167)

Hsp90 inhibition decreases the adipogenic transcriptional program without any effect on cytotoxicity. by Sébastien Desarzens (547289)

Gfap typically increases with disease progression but decreases in some models in advanced stages of degeneration. by Claire Hippert (171005)

“…<b>E</b>. <i>Pde6b</i>^{<i>rd1/rd1</i>} animals showed a bimodal pattern of Gfap synthesis, with staining being particularly strong at the mid stage, but decreasing thereafter (i-vi). …”

mPEG PV1-Fab’ treatment decreases T_reg population. by Pedro Henrique Papotto (791904)

Decreased ISCs and increased goblet cells after intestinal specific loss of MLL1. by Neha Goveas (11790822)

“…<p><b>(A)</b> Kaplan-Meier survival curve. Tamoxifen was given by gavage for 6 days to mice with the genotype <i>Mll1</i>^{<i>FC/+; Vil-Cre-ERT2/+</i>} (n = 12) and <i>Mll1</i>^{<i>FC/FC; RC/+</i>} (n = 18). …”

VEEV CPD shows decreased phosphorylation of capsid and replication is not sensitive to loss of PKCδ. by Brian D. Carey (6092747)

Exposure to low CO₂ levels decreases ER cholesterol levels. by Nityanand Bolshette (17396845)

“…<b>(C)</b> Total cholesterol quantification (with fluorometric assay kit) in NIH3T3 cells depleted with sterols for 2 h or exposed to different CO₂ levels for 4 h (mean ± SE, <i>n</i> = 3 biological replicates per condition, **<i>P</i> < 0.01, nonsignificant (ns), two-sided Student’s <i>t</i> test). <b>(D, E)</b> The free cholesterol and cholesterol ester levels in the ER membrane from the cells as in <b>(C)</b>, were quantified with shotgun lipidomics analysis (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s007" target="_blank">S7 Fig</a> and <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s012" target="_blank">S5 Table</a>) (mean ± SE, <i>n</i> = 3 independent experiments, **<i>P</i> < 0.01, *<i>P</i> < 0.05, nonsignificant (ns) two-sided Student’s <i>t</i> test). …”

DHT increases whereas orchidectomy decreases the weight and cross sectional area of hindlimb muscles. by Young-Eun Yoo (323357)

“…<b>A:</b> In WT mice, DHT increased the GN weight by 7% (212.4±8.8 mg), whereas orchidectomy decreased it by 14% (171.4±9.0 mg) compared with control WT mice (198.4±5.5 mg). …”

Transcription of feeding peptides and inflammation markers were regulated by treatment with palmitate in mHypoE-46 neurons. by Wenqing Ye (3015147)

Loss of <i>Nf1</i> increases sleep fragmentation and decreases sleep depth. by Elizabeth B. Brown (4582978)

“…Compared to controls, pan-neuronal knockdown of <i>Nf1</i> significantly reduces sleep during the day (nsyb/+, <i>P</i><0.0001; <i>Nf1</i>^RNAi/+, <i>P</i><0.0001) and night (nsyb/+, <i>P</i><0.0001; <i>Nf1</i>^RNAi/+, <i>P</i><0.0004). <b>E</b>. There is a significant effect of genotype on bout number (two-way ANOVA: F_2,312 = 7.728, <i>P</i><0.0005). …”

eATP stimulation of RA decreased endothelial function. by Padmini Komalavilas (402160)

Bilirubin decreases the viability of <i>E. faecalis</i>. by Christopher L. Nobles (437464)

Global Land Use Change Impacts on Soil Nitrogen Availability and Environmental Losses by Jing Wang (6206297)

“…Anthropogenic activities, particularly land use change and management practices, alter the global nitrogen (N) cycle. As a central part of the global N cycle, soil N supply from net N mineralization (NNM) and net nitrification (NN) contributes to over 50% of crop N uptake. …”

Rho kinase (ROCK) inhibitors promote neurite elongation of human model neurons. by Frank Roloff (695802)

Ibuprofen increased neurite length of human model neurons. by Frank Roloff (695802)

Revisiting the sealed heating method–heating cells in a low volume decreases nuclear Chk1. by Andrew J. Massey (239469)