Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben... by Shuhei Ikeda (2380180)

Subjects:

RDA analysis of environmental factors and fungal community composition (A), diversity (B). by Xiaoqing Li (186909)

50 year old female with Libman-Sacks endocarditis complicated with an acute transient ischemic attack, past stroke, and seizure disorder. by Carlos A. Roldan (10151007)

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Stable isotopes in algae and mussels. by Antonio Bode (1473376)

Relationships between stable isotopes and nitrate anomalies. by Antonio Bode (1473376)

Regression models of COVID-19-related racial discrimination and anxiety symptoms among the full sample. by Ronna Bañada (19233063)

Relationships between hardness and IDDSI levels. by Muxi Chen (9294270)

“…The goal was to provide objective data to support the development of safe and nutritious diets tailored to the swallowing abilities of the elderly.</p><p>Methods</p><p>A cross-sectional observational study was conducted, using web-scraping technology to identify 26 commonly preferred food ingredients among elderly individuals across seven regions of China. …”

LPS administration demonstrated a significant decrease in the protein expression of both claudin-1 and occludin in BF fed mice as compared to control mice. by Valentina Di Caro (510473)

Leptin deficit hypoxia exposed-MSCs failed to limit cardiac fibroblast activation, through TGF-β/Smad2 and MRTF-A. by Panpan Chen (307628)

A-C. Inhibitors of cell death (zVAD-fmk and Nec-1) do not rescue the BMP2-induced decrease in cell numbers. by Charlotte Lagler (4017212)

Effect of MF (2 MT, 50 Hz) on VEGFR expression and activation. by Simona Delle Monache (402973)

“…<p>Protein of equal quantity was separated by 8% SDS-page and electroblotted on to a PVDF membrane. Representative blots show effects exerted by MF (2 mT, 50 Hz) on VEGFR2 total expression and phosphorylation after 1 h, 6 h and 12 h of exposure A). …”

ChemRich enrichment of the top 50 most changed metabolites for SCD. by Juliette Cooke (11402543)

A small group of plains zebra taken at a real-world equivalent of 16.4 m as they may appear to a human (a,c,e) and lion (b,d,f) under photopic (bright; daylight), mesopic (dim; dus... by Amanda D. Melin (270203)

50% reduction of kinesin-1 or dynein is sufficient to perturb neuronal growth. by Gary J. Iacobucci (192833)

“…<p>(<b>A</b>) Representative neuronal cultures expressing APP-YFP and APP-YFP with 50% genetic reduction of either kinesin-1 or dynein are shown at day 1 and day 2. …”

Table_1_Decrease in Admissions and Change in the Diagnostic Landscape in a Newborn Care Unit in Northern Ghana During the COVID-19 Pandemic.DOC by Alhassan Abdul-Mumin (5986151)

“…</p><p>Conclusion: We observed a marked decrease in admissions and change in the diagnosis landscape and related mortality during the pandemic. …”

Dependence of seizure transition times on (<i>dν</i>_<i>se</i>/<i>dt</i>)^−1/2 with the default parameters as in Table 1 and Δ ranges from 2 s to 50 s. by F. Deeba (8661837)

Neural networks classify states which differ in neuronal activity levels using ensembles of neurons that increase/decrease their activity in each state. by Nicholas A. Frost (10739821)

“…As a result, there is an increase (neurons 51:100) or decrease (neurons 1:50) in activity levels in State B compared to State A. …”

<i>Vps34</i> KO MEFs show a decrease in LC3 conjugation and LC3 puncta formation upon starvation. by Kelly Devereaux (466106)