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Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach
Published 2017“…Missense mutations of the HNF1A were retrieved from public databases and subjected to a three-step computational mutational analysis to identify the underlying mechanism. …”
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Effect of BPA on CYP450s expression, and nicotine modulation, in fetal rat brain
Published 2022“…Fetal brains were isolated at gestational days GD14 and GD19, and protein expression was assessed by Western blotting. Results showed a BPA-induced significant decrease in CYP1B1 expression levels at GD14 (p = 0.001), and CYP19A1 (aromatase) expression at both mid- and late-stage development (p < 0.001). …”
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Genotoxic impact of long-term cigarette and waterpipe smoking on DNA damage and oxidative stress in healthy subjects
Published 2019“…This was associated with a marked decrease (50%) in the expression of detoxifying genes (NQO1 and GSTA1) with an increase in CYP1A1 mRNA expression, a cancer-activating gene. …”
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Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2.
Published 2018“…Molecular docking analysis revealed a decrease in interaction between the protein and ATP in all the 3 mutations, and molecular dynamic simulations of 50 ns showed a loss of stability and compactness in the mutant proteins. …”
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Development of CuAg/Cu2O nanoparticles on carbon nitride surface for methanol oxidation and selective conversion of carbon dioxide into formate
Published 2020“…The lower reduction potential of copper ([Cu+(aq) + e− → Cu(s)], + 0.52 eV) compared to Ag ([Ag+(aq) + e− → Ag(s)], +0.80 eV) makes Cu(0) easily exchangeable by Ag+ ions via galvanic exchange without applying any external bias. In a two-step process, the Cu NPs are synthesized first on CN surface by adsorbing Cu2+ precursors and reducing them by NaBH4. …”
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Coral reef resilience differs among islands within the Gulf of Mannar, southeast India, following successive coral bleaching events
Published 2021“…Overall, between 2005 and 2017 reefs had a simultaneous decrease in relative coral cover (avg. = ? …”
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MOLECULAR FEATURES OF TRIPLE NEGATIVE BREAST CANCER STEM CELLS: A GENE EXPRESSION PROFILING ANALYSIS OF MDA-MB-231 CELLS
Published 2021“…Triple negative breast cancer (TNBC) is a chemoresistant subtype of female breast tumors. …”
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A process for CO2 capture and brine salinity reduction through reaction with potassium hydroxide: A multi-stage evaluation
Published 2022“…In the third method, the recovery of Ca2+ and Mg2+ was approximately 76.3% and 94.6%, respectively, following the pre-treatment step (filtration), followed by the same stages as in the second method. …”
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A new insight into the separation of oil from oil/water emulsion by Fe3O4?SiO2 nanoparticles
Published 2021“…For the oil recovery process, the Fe3O4 was applied for the inhibition (i.e., decrease) of oil sedimentation, and the SiO2 NPs were applied for wettability alteration and IFT reduction. …”
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Investigational Study for the efficiency of Fe3O4@SiO2 nanoparticles in the Oil Recovery Process using glass micromodel
Published 2021“…For the oil recovery process, the Fe3O4 was applied for the inhibition (i.e., decrease) of oil sedimentation, and the SiO2 NPs were applied for wettability alteration and IFT reduction. …”
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Surface Roughness Modelling of the Micromechanically Patterned CNT Forests
Published 2023“…One of the top-down microforming methods of CNT forests is called micromechanical bending (M2B). The method uses a high-speed rotating spindle to compact and flatten the surface of CNT forests. …”
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A novel index based on planktonic copepod reproductive traits as a tool for marine ecotoxicology studies
Published 2020“…At high concentrations, cadmium and silver induce an increase in EPR in the copepods Acartia tonsa and Acartia hudsonica, while exposure to mercury decreases EPR in adults by 50%. All three metals affect HS, with mercury inducing a stronger effect than cadmium and silver. …”
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Appropriateness of gentamicin therapeutic drug monitoring at a Middle Eastern tertiary hospital setting: a retrospective evaluation and quality audit
Published 2024“…Objective: This study aimed to evaluate the appropriateness of gentamicin therapeutic drug monitoring (TDM) at a tertiary care hospital in Qatar. Methods: A one-year quantitative retrospective chart review of all gentamicin TDM records was conducted. …”
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Enhanced boron removal by electricity generation in a microbial fuel cell
Published 2016“…Two scenarios were examined, the MFC as a pretreatment process and the MFC as a post-treatment step in connection with conventional desalination. …”
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