A computational model to predict the structural and functional consequences of missense mutations in O6-methylguanine DNA methyltransferase by Thirumal Kumar, D

“…MDS run showed that the C145A mutant demonstrated higher structural deviation, decreased compactness, and the binding patterns. …”
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Table_1_Trends and Disparities in the Incidence of Intraocular Foreign Bodies 1990–2019: A Global Analysis.DOCX by Minjie Yuan (11568097)

“…From 35.79 million (95% UI 23.62–50.89) in 1990 to 46.63 million (95% UI 32.45–64.45) in 2019, the number of IOFB incident cases worldwide increased by 30.29% (95% UI 19.63–43.55). …”

Supplementary Material for: Microbial Intervention as a Novel Target in Treatment of Non-Alcoholic Fatty Liver Disease Progression by Zhou Y. (3218202)

“…<b><i>Methods:</i></b> 50 male SD rats were randomly divided into five groups with or without a high fat diet (HFD), antibiotics, and probiotics, in order to establish an imbalanced gut microbiota and probiotic treatment model in NAFLD rats. …”

Biochar Decelerates Soil Organic Nitrogen Cycling but Stimulates Soil Nitrification in a Temperate Arable Field Trial by Judith Prommer (517077)

“…While gross rates of organic N transformation processes were reduced by 50–80%, gross N mineralization of organic N was not affected. …”

Association between Polymorphisms in the Promoter Regions of Matrix Metalloproteinases (MMPs) and Risk of Cancer Metastasis: A Meta-Analysis by Dan Liu (108669)

“…In subgroup analysis based on cancer type, associations were found in head/neck and breast cancer under the recessive model, and also in breast cancer under the dominant model. For <em>MMP3 (−1171) 5A/6A</em>, the polymorphism decreased the overall risk of metastasis under two genetic models (recessive: OR = 0.80, 95%CI = 0.64–0.99, dominant: OR = 0.72, 95%CI = 0.56–0.93). …”

Development of the Nb474H/IgM8A2-B “hybrid” sandwich ELISA prototype. by Steven Odongo (2143756)

“…A high signal intensity (OD_450nm) observed at higher concentrations of IgM8A2-B tapered with the decreasing concentrations of the mAb indicating that Strep-HRP was binding coated IgM8A2-B. …”

The Number of Patients and Events Required to Limit the Risk of Overestimation of Intervention Effects in Meta-Analysis—A Simulation Study by Kristian Thorlund (149383)

“…<div><h3>Background</h3><p>Meta-analyses including a limited number of patients and events are prone to yield overestimated intervention effect estimates. …”

Nutritional Support for Patients Sustaining Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Prospective Studies by Xiang Wang (127867)

“…Small-bowel feeding was found to be with a decreasing rate of pneumonia compared with nasogastric feeding (RR = 0.41; 95% CI, 0.22–0.76).…”

An Early-Onset Subgroup of Type 2 Diabetes: A Multi-Generational, Prospective Analysis in the Framingham Heart Study by Justin B. Echouffo-Tcheugui (9388233)

“…In second-generation participants, having a parent with early-onset diabetes increased diabetes risk by 3.24-fold (1.73-6.07) whereas having one or both parents with late-onset diabetes increased diabetes risk by 2.19-fold (1.50-3.19).…”

Image_1_Effects of Perioperative Dexmedetomidine on Immunomodulation in Uterine Cancer Surgery: A Randomized, Controlled Trial.tif by Jin Sun Cho (11710808)

“…Objective<p>Dexmedetomidine has sympatholytic, anti-inflammatory, and analgesic effects and may exert anti-tumor effect by acting on α2A adrenoreceptor. We investigated whether perioperative dexmedetomidine preserves immune function in patients undergoing uterine cancer surgery.…”

DataSheet1_A novel hybrid bioprocess strategy addressing key challenges of advanced biomanufacturing.PDF by Lucas Nik Reger (14632742)

“…The novel process showed increased productivity (+217%) as well as longer cultivation duration, in comparison to a standard FB with a significantly lower media consumption per produced product (−50%) and a decreased need for process monitoring, in comparison to a perfusion cultivation. …”

Datasheet1_Fever management in children and insights into fever of unknown origin: a survey among Italian pediatricians.pdf by Elena Chiappini (304802)

Data Sheet 1_Cytomegalovirus infection in infants with biliary atresia in China: a multi-center investigation study.docx by Yilin Zhao (487866)

“…</p>Conclusion<p>Among the 1,276 infants with BA in this cohort, 31.3% (399 cases) had concomitant CMV infection, representing a decrease compared to previous data. CMV-IgM played a crucial role in the detection of the infection. …”

Image_1_TnP Peptide Suppresses Experimental Autoimmune Encephalomyelitis (EAE) in a Preclinical Mouse Model.pdf by Carla Lima (428557)

“…We have shown that TnP possesses a disease suppressive function in EAE, ameliorating disease severity by 40% and suppressing the accumulation of T helper (Th)1- and Th17-producing lymphocytes (by 55% and 60%, respectively) in CNS along with activated microglia/macrophages populations (by 33% and 50%, respectively), and also conferred a protective effect anticipating the remyelination process to day 66 compared to day 83 of untreated cuprizone-mice. …”

Video_3_Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish.MP4 by Lise Heylen (11561266)

Video_2_Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish.MP4 by Lise Heylen (11561266)

Hydroxysafflor Yellow A Ameliorates Renal Fibrosis by Suppressing TGF-β1-Induced Epithelial-to-Mesenchymal Transition by Naping Hu (2614399)

“…The aim of this study was to investigate whether Hydroxysafflor yellow A (HSYA) can preserve renal function by inhibiting the progression of renal fibrosis and the potential mechanisms.…”

Sensitivity analysis of LMR thresholds based on ROC curves for associated variables. by Daysi Zulema Diaz-Obregón (22537744)

Table_1_Causal association of gut microbiota on spondyloarthritis and its subtypes: a Mendelian randomization analysis.xlsx by Jun Tang (32983)

“…The family Rikenellaceae id.967 was associated with a reduced risk of both AS (OR = 0.66 (95% CI: 0.47–0.93); p = 1.81E−02) and psoriatic arthritis (OR = 0.70 (95% CI: 0.50–0.97); p = 3.00E−02). …”

Table_3_Causal association of gut microbiota on spondyloarthritis and its subtypes: a Mendelian randomization analysis.xlsx by Jun Tang (32983)

“…The family Rikenellaceae id.967 was associated with a reduced risk of both AS (OR = 0.66 (95% CI: 0.47–0.93); p = 1.81E−02) and psoriatic arthritis (OR = 0.70 (95% CI: 0.50–0.97); p = 3.00E−02). …”